Oxidative stress in pediatric nephrotic syndrome

Kamireddy, Rajani; Kavuri, Suchitra; Devi, Sivanesan Saravana; Vemula, Harathi; Chandana, Devi; Harinarayanan, Salini; James, R. Connor; Rao, Anjali

doi:10.1016/s0009-8981(02)00294-2

Cited by 27 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Plasma protein thiols act as antioxidants [9]. Since the association of oxidative injury and NS is well documented [1,2,3, 10], the decrease in protein thiols in this study may be due to the adaptive response of the body to the pro-oxidant status in NS. Further, the total antioxidant power of the plasma measured as FRAP in NS shows a significant increase when compared to controls.…”

Section: Discussionmentioning

confidence: 81%

“…Reactive oxygen species promote cell injury by lipid peroxidation, which disrupts the structural integrity of the tubular epithelial cells, increases glomerular permeability to proteins and alters glomerular hemodynamics [1,2,3]. NS is characterized by massive albuminuria.…”

Section: Introductionmentioning

confidence: 99%

“…Albumin, the plasma protein which maintains the oncotic pressure provides the bulk of total plasma thiols, which are well-known antioxidants [4]. Children with NS presenting with decreased immunity and increased oxidative stress are prone to relapse [1]. Hence, in the present study, biomarkers of oxidative stress like plasma protein thiols and total ferric-reducing/antioxidant power (FRAP) were measured in pediatric NS patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma Protein Thiols and Total Antioxidant Power in Pediatric Nephrotic Syndrome

et al. 2008

Self Cite

View full text Add to dashboard Cite

Background: Oxidative damage by free radicals has been implicated in kidney injury, especially in nephrotic syndrome (NS). Such a stress would influence the response of nephrotic children to therapy. Methods: The present study enrolled children with NS in active disease state and in remission and 50 healthy volunteers. Plasma protein thiol levels and ferric-reducing/antioxidant power were estimated spectrophotometrically in controls and in patients. Serum protein and albumin as well as urine protein were also estimated. Results: There was a significant decrease in plasma protein thiol levels in children with active disease when compared to controls as well as to subjects in remission. Ferric-reducing/antioxidant power values were significantly increased in NS and remained high in remission when compared to controls. Serum total protein and albumin were significantly decreased in nephrotics compared to controls. Further, a prospective study between the relapse and remission groups indicated a significant increase in plasma protein thiols in remission when compared to relapse exhibiting a positive response to treatment. Conclusion: A considerable alteration in the antioxidant status in NS indicates the pro-oxidant milieu existing in this condition which may have implications in the response to treatment of these patients.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma Protein Thiols and Total Antioxidant Power in Pediatric Nephrotic Syndrome

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…The cell injury induced by ROS disrupts the integrity of the tubular epithelial cells and increases glomerular permeability to proteins resulting in nephrotic syndrome. 7 Due to the extremely short half life of ROS, such as free radicals, it is not feasible to test it directly. Malonyldialdehyde (MDA), by-product of lipid peroxidation, is often tested to predict the status of ROS indirectly.…”

Section: Introductionmentioning

confidence: 99%

“…Malonyldialdehyde (MDA), by-product of lipid peroxidation, is often tested to predict the status of ROS indirectly. 7,8 Also, the micronutrients including vitamin C and E are non-enzymatic antioxidants that will decline due to the consumption of oxidative stress. In this sense, it is reasonable to hypothesize that the alterations of MDA, vitamin C and E may be associated with INS.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

Mao¹,

Zhang²,

Huang³

2014

Renal Failure

View full text Add to dashboard Cite

It is well documented that oxidative stress is involved in the pathogenesis of idiopathic nephrotic syndrome (INS). Malondialdehyde (MDA) is a measurement of lipid oxidation; vitamin C and E are important components of antioxidants. However, the association between MDA, vitamin C or E levels and INS remains elusive. A meta-analysis was performed to investigate the alteration of serum levels of MDA, vitamin C and E in INS compared with controls. Eight studies were included in our meta-analysis according to predefined criteria. Active INS patients demonstrated significantly higher level of serum MDA (SMD: 2.13, 95% CI: 1.511 to 2.749, p510 ) and similar level of serum vitamin E compared with those in controls. No significant publication bias was observed. In conclusion, the disorder of MDA and vitamin C persists in the remission stage of INS. It seems that the serum levels of vitamin C and E is associated with the responsiveness of INS to steroids. However, more studies should be performed in the future.

show abstract

Antioxidant status of children with idiopathic nephrotic syndrome

et al. 2010

View full text Add to dashboard Cite

The production of free radicals can cause renal injury and play an important role in the pathogenesis of idiopathic nephrotic syndrome. Markers of reactive oxygen species (ROS) were evaluated in 48 patients with active nephrotic syndrome (ANS) and 30 age- and gender-matched healthy children. Plasma malondialdehyde (MDA), protein carbonyl, nitrite, copper, zinc, selenium, ascorbic acid, and superoxide dismutase (SOD) levels were estimated in patients with ANS and controls. Measurements were repeated in 39 cases after achievement of remission, and in 10 other children who were in remission of >6 months' duration. Plasma MDA and nitrite levels were significantly higher and selenium was lower in ANS patients compared with controls. Plasma protein carbonyl, copper ascorbic acid, zinc, and superoxide dismutase levels were comparable in ANS patients and controls. Plasma copper level was significantly higher in active cases than in the remission and long-term remission groups. Selenium value showed a rise and then normalized in long-term remission. Among different sub-groups of ANS, no significant differences were found in the levels of various parameters, except plasma selenium, which was significantly lower in first-attack nephrotic syndrome (FANS) in comparison to infrequently relapsing nephrotic syndrome (IRNS) and frequently relapsing nephrotic syndrome (FRNS) patients. Thus, we observed evidence of oxidative stress and impaired antioxidant defense during acute nephrotic syndrome. Antioxidant status recovered completely only during long-term remission.

show abstract

Oxidative stress in pediatric nephrotic syndrome

Cited by 27 publications

References 13 publications

Plasma Protein Thiols and Total Antioxidant Power in Pediatric Nephrotic Syndrome

Plasma Protein Thiols and Total Antioxidant Power in Pediatric Nephrotic Syndrome

Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

Antioxidant status of children with idiopathic nephrotic syndrome

Contact Info

Product

Resources

About