2009
DOI: 10.1016/j.jss.2007.12.753
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Oxidative Stress in Relation to Surgery: Is There a Role for the Antioxidant Melatonin?

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Cited by 76 publications
(67 citation statements)
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References 82 publications
(96 reference statements)
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“…In comparison to other known scavengers, due to its lipophilic properties, melatonin is considered as a hydrophobic antioxidant. This property enables it to easily pass morphophysiological barriers without receptors or a specific location [20]. In particular, melatonin plays a protective role in mitochondrial function and homeostasis, reducing and preventing mitochondrial oxidative stress, which leads to a reduction in apoptosis [15,21,22].…”
Section: Introductionmentioning
confidence: 99%
“…In comparison to other known scavengers, due to its lipophilic properties, melatonin is considered as a hydrophobic antioxidant. This property enables it to easily pass morphophysiological barriers without receptors or a specific location [20]. In particular, melatonin plays a protective role in mitochondrial function and homeostasis, reducing and preventing mitochondrial oxidative stress, which leads to a reduction in apoptosis [15,21,22].…”
Section: Introductionmentioning
confidence: 99%
“…It is a highly effective antioxidant, scavenging hydroxyl radicals and inhibiting the production of nitric oxide (Gitto et al, 2011;Serel et al, 2004) and other antioxidants like vitamins E and C (Kücükakin et al, 2009). The ability of melatonin to counteract ROS formation is due to the special characteristic of this substance to cross morpho and physiological barriers distributed in tissues, cells and sub-cellular compartments due to its distinct physical and chemical properties (Costa et al, 1995;Tomás-Zapico et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…The ability of melatonin to counteract ROS formation is due to the special characteristic of this substance to cross morpho and physiological barriers distributed in tissues, cells and sub-cellular compartments due to its distinct physical and chemical properties (Costa et al, 1995;Tomás-Zapico et al, 2005). In addition, the "hormone of darkness" and messenger of the photoperiod is also well known to exhibit strong direct and indirect antioxidant properties, one of which is capturing ROS directly and another is stimulating gene expression and the activity of some enzymes that can activate enzymatic antioxidants (Kücükakin et al, 2009). This demonstrates that the surgical removal of the pineal gland, one source of melatonin, exacerbates the tissue damage caused by free radicals (Reiter et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
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“…Мелатонин явля ется наиболее эффективным антиоксидантом по сравнению с витаминами Е и С при сепсисе [15], воздействии радиации [16], сахарном диабете [17], гепатопатологии и холестазе [18].…”
Section: резюмеunclassified