Oxidative Stress in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Rahman, Irfan

doi:10.1007/3-540-32232-9_6

Cited by 5 publications

(5 citation statements)

References 121 publications

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“…[33][34][35][36][37][38] We have suggested that EGR-1 can also stimulate HSP70 elevation in an ERK 1/2-dependent manner, which is thought to regulate cigarette smoke-induced inflammatory processes. 18 Here we provide the first evidence that EGR-1 could activate MAPK ERK 1/2 in a positive feedback manner through increasing Ras prenylation by promoting GGPPS transcription in lung epithelial cells during CSE challenge (Figure 6).…”

Section: Discussionmentioning

confidence: 99%

GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation

Shen

Shao

Lai

et al. 2011

The American Journal of Pathology

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Cigarette smoke activates the extracellular signal-regulated kinase (ERK) 1/2 mitogen activated-protein kinase pathway, which, in turn, is responsible for early growth response gene-1 (EGR-1) activation. Here we provide evidence that EGR-1 activation can also reactivate ERK 1/2 mitogen activated-protein kinase through a positive feedback loop through its target gene (geranylgeranyl diphosphate synthase) GGPPS. For the first time, the GGPPS gene is identified as a target of EGR-1, as EGR-1 can directly bind to the predicted consensus-binding site in the GGPPS promoter and regulate its transcription. Long-term observations show that there are two ERK 1/2 phosphorylation peaks after cigarette smoke extract stimulation in human lung epithelial Beas-2B cells. The first peak (at 10 minutes) is responsible for EGR-1 accumulation, and the second (at 4 hours) is diminished after the disruption of EGR-1 transcriptional activity. EGR-1 overexpression enhances Ras prenylation and membrane association in a GGPPS-dependent manner, and it augments ERK 1/2 activation. Likewise, a great reduction of the second peak of ERK 1/2 phosphorylation is observed during long-term cigarette smoke extract stimulation in cells where GGPPS is disrupted. Thus, we have uncovered an intricate positive feedback loop in which ERK 1/2-activated EGR-1 promotes ERK 1/2 reactivation through promoting GGPPS transcription, which might affect cigarette smoke-related lung pathological processes.

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Section: Discussionmentioning

confidence: 99%

GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation

Shen

Shao

Lai

et al. 2011

The American Journal of Pathology

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“…Macrophage -killing capacity diminishes and the recruitment of previously mentioned cells to the site of inflammation is compromised in smokers (Galvin and Franks, 2009). High levels of oxidative stress potentially play a role in the progression and exacerbation of chronic obstructive pulmonary disease (COPD) (Rahman, 2005). COPD is the third leading cause of death in the United States and, due to the long-term nature of care required, is projected to cost the U.S. health care system $49.0 billion in 2020 (Centers for Disease Control and Prevention, 2018).…”

Section: Effects Of Nicotine and Smoking On The Lungsmentioning

confidence: 99%

Dual Substance Use of Electronic Cigarettes and Alcohol

Wetzel

Wyatt

2020

Front. Physiol.

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Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long history of the comorbidity of alcohol and nicotine use, the rising prevalence of ECs raises the question as to their role in the consumption of alcohol. Of the numerous models of ECs available, JUUL is the most popular. This narrative review aims to determine current trends in literature regarding the relationship between EC and alcohol dual use, as well as hypothesize potential pathogenic tissue damage and summarize areas for future study, including secondhand vapor exposure and calling for standardization among studies. In summary, EC users are more likely to participate in hazardous drinking and are at higher risk for alcohol use disorder (AUD). We surmise the pathogenic damage of dual use may exhibit an additive effect, particularly in pathogen clearance from the lungs, increased inflammation and decreased immune response, physical damage to epithelial cells, and exacerbation of chronic obstructive pulmonary disease (COPD)-like illnesses. A better understanding of pathogenic damages is critical to understand the risks placed on dual users when exposed to respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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“…One of the primary causes of metabolic syndrome, Alzheimer's disease, Parkinson's disease, cardiovascular diseases, stroke, chronic kidney disease, and chronic pulmonary obstructive disease is oxidative stress (Barnham et al., 2004; Dhalla et al., 2000; Khansari et al., 2009; Perera & Handuwalage, 2015; Rahman, 2005; Small et al., 2012).…”

Section: Pharmacological Aspectsmentioning

confidence: 99%

Ethnobotanical and phytochemical aspects of the edible herb Coriandrum sativum L.

Sobhani

Mohtashami

Amiri

et al. 2022

Journal of Food Science

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Coriandrum sativum (coriander) is an edible herb in the family Apiaceae. The leaves, fruits, and stems of C. sativum have long been used as culinary spice due to their favorable odor. Traditional practitioners used this plant for treating different diseases like blepharitis, scabies, aphthous stomatitis, laryngitis, headache, and palpitation. In modern researches, coriander has demonstrated anxiolytic, anticonvulsant, antimigraine, neuroprotective, analgesic, diuretic, hypoglycemic, hypolipidemic, hypotensive, anticancer, and antioxidant activities. Coriander contains a wide range of bioactive phytochemicals among which phenylpropenes, terpenoids, isocoumarins, phytosterols, and fatty acids are the most important. This review provides information about the botanical and ethnobotanical aspects, chemical profile, therapeutic uses in Islamic traditional medicine (ITM), and recent pharmacological studies of coriander effects. The results have shown that coriander and its monoterpenoid compound, linalool, can be considered as potential drug candidates for treating metabolic syndrome and different inflammatory conditions especially neural and CNS diseases.

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Oxidative Stress in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Cited by 5 publications

References 121 publications

GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation

GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation

Dual Substance Use of Electronic Cigarettes and Alcohol

Ethnobotanical and phytochemical aspects of the edible herb Coriandrum sativum L.

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