Oxidative stress indicators in patients with an exacerbation of COPD

Soodaeva, Svetlana; Kubysheva, Nailya; Klimanov, Igor; Li, Timur; Glukhova, Mary; Eliseeva, Tatyana; Nikitina, L.Yu.

doi:10.1183/13993003.congress-2018.pa933

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“…In our work studying the content of metabolites of the nitric oxide cycle in various diseases of the respiratory organs and comorbid conditions, it has been shown that among NO metabolites, nitrate anions have the highest concentration [ 65 , 66 ]. The levels of nitrite anion vary from undetectable values (especially in EBC) to 20% of the total concentration of nitrate and nitrite anions.…”

Section: Introductionmentioning

confidence: 99%

“…The levels of nitrite anion vary from undetectable values (especially in EBC) to 20% of the total concentration of nitrate and nitrite anions. The ratio of nitrate to nitrite anions varies depending on the pathophysiological conditions [ 65 , 66 ]. The concentrations also vary significantly depending on the biological environment under study, from units of μ M in EBC to hundreds of mM in urine [ 67 ].…”

Section: Introductionmentioning

confidence: 99%

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The State of the Nitric Oxide Cycle in Respiratory Tract Diseases

Soodaeva

Klimanov

Kubysheva

et al. 2020

Oxidative Medicine and Cellular Longevity

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This review describes the unique links of the functioning of the nitric oxide cycle in the respiratory tract in normal and pathological conditions. The concept of a nitric oxide cycle has been expanded to include the NO-synthase and NO-synthase-independent component of its synthesis and the accompanying redox cascades in varying degrees of reversible reactions. The role of non-NO-synthase cycle components has been shown. Detailed characteristics of substrates for the synthesis of nitric oxide (NO) in the human body, which can be nitrogen oxides, nitrite and nitrate anions, and organic nitrates, as well as nitrates and nitrites of food products, are given. The importance of the human microbiota in the nitric oxide cycle has been shown. The role of significant components of nitrite and nitrate reductase systems in the nitric oxide cycle and the mechanisms of their activation and deactivation (participation of enzymes, cofactors, homeostatic indicators, etc.) under various conditions have been determined. Consideration of these factors allows for a detailed understanding of the mechanisms underlying pathological conditions of the respiratory system and the targeting of therapeutic agents. The complexity of the NO cycle with multidirectional cascades could be best understood using dynamic modeling.

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Section: Introductionmentioning

confidence: 99%