Oxidative stress, inflammatory settings, and microRNA regulation in the recurrent implantation failure patients with metabolic syndrome

Sheikhansari, Golshan; Soltani‐Zangbar, Mohammad Sadegh; Pourmoghadam, Zahra; Kamrani, Amin; Azizi, Ramyar; Aghebati‐Maleki, Leili; Danaii, Shahla; Koushaeian, Ladan; Hojjat‐Farsangi, Mohammad; Yousefi, Mehdi

doi:10.1111/aji.13170

Cited by 40 publications

(26 citation statements)

References 63 publications

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“…In contrast, the MPO activity was higher in MetS subjects compared to those without MetS. Similar results were previously observed, showing that recurrent implantation failure patients with MetS (RIF-MS) decreased SOD and CAT levels in comparison with a control group, whereas the MPO levels increased in the MetS group [16]. Moreover, it has been also reported that MPO activity progressively increases with obesity and MetS [44].…”

Section: Discussionsupporting

confidence: 87%

“…This study reveals that inflammatory mediators in plasma, IL-6, and TNFα, exhibited higher significant levels in patients with MetS in comparison to patients without MetS. TNFα circulates throughout the body responding to stimuli, such as infectious agents or tissue injury, altering properties of vascular endothelial cells, and regulating metabolic activities of other tissues [16,46]. The expression of IL-6 is readily induced by a variety of cytokines, lipopolysaccharide, or viral infections; for these reasons, high IL-6 levels are associated with inflammatory responses [54].…”

Section: Discussionmentioning

confidence: 78%

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Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

et al. 2020

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Metabolic syndrome (MetS) is associated with increased risk of developing diabetes and cardiovascular diseases. MetS is also characterized by an increase of oxidative stress which contributes to impaired inflammation, vascular function, and atherosclerosis. The aim was to assess the oxidative stress and inflammatory markers in plasma and PBMCs in adults with or without MetS. Antioxidant and inflammatory parameters were measured in peripheral blood mononuclear cells (PBMCs) of 80 men and 80 women over 55 to 80-years-old residing in the Balearic Islands without previously documented cardiovascular disease. Circulating leukocytes, neutrophils, lymphocytes, basophils, and monocytes were higher in MetS subjects with respect to those without MetS. Plasma levels of malondialdehyde, tumor necrosis factor α (TNFα), and interleukin 6 (IL-6) levels were higher in MetS subjects in both genders, but the superoxide dismutase activity was lower. The myeloperoxidase plasma activity was higher in the MetS male subjects. Higher activities and protein levels of catalase and glutathione reductase in PBMCs were observed in MetS subjects in both genders. Obtained data show that MetS is associated with oxidative stress and a proinflammatory state and with high antioxidant defenses in PBMCs probably derived from a pre-activation state of immune cells.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 78%

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

et al. 2020

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“…Sheikhansari et al have shown increased OxS and inflammatory factors in MetS women as compared to healthy probands. Moreover, MetS elicited decreased expression of miR-223 and miR-146a and upregulation of miR-21 in peripheral blood mononuclear cells (PBMCs) [286]. Other studies indicated that downregulation of miR-223 promotes increase of IL-1β and IL-6 production [287].…”

Section: Microrna In Mets-a Link With Chronic Inflammation Related Tomentioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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“…GSH was found to be decreased only in Pakistani exposed group. A decrease in activity of these enzymes would favor the accumulation of free oxygen radicals in erythrocytes and other cells, leading to tissue damage which could be significantly detrimental when pesticides exposure persists over several years and may ultimately be responsible for multipletissue and organ damages (neurological, metabolic, hepatic, and renal) [45][46][47]. We also observed an increase in MDA and FRAP in OP-exposed individuals.…”

Section: Discussionmentioning

confidence: 63%

Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan

Javeres

Habib

Laure

et al. 2020

IJMS

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The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. However, several studies have shown that AChE inhibition alone cannot explain all the toxicological manifestations in prolonged exposure to OPs. The present study aimed to assess the status of antioxidants malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) (reduced), catalase, and ferric reducing antioxidant power (FRAP) in chronic OP-exposed groups from Cameroon and Pakistan. Molecular analysis of genetic polymorphisms (SNPs) of glutathione transferases (GSTM1, GSTP1, GSTT1), catalase gene (CAT, rs7943316), sirtuin 1 gene (SIRT1, rs10823108), acetylcholinesterase gene (ACHE, rs2571598), and butyrylcholinesterase gene (BCHE, rs3495) were screened in the OP-exposed individuals to find the possible causative association with oxidative stress and toxicity. Cholinesterase and antioxidant activities were measured by colorimetric methods using a spectrophotometer. Salting-out method was employed for DNA extraction from blood followed by restriction fragment length polymorphism (RFLP) for molecular analysis. Cholinergic enzymes were significantly decreased in OP-exposed groups. Catalase and SOD were decreased and MDA and FRAP were increased in OP-exposed groups compared to unexposed groups in both groups. GSH was decreased only in Pakistani OPs-exposed group. Molecular analysis of ACHE, BCHE, Catalase, GSTP1, and GSTM1 SNPs revealed a tentative association with their phenotypic expression that is level of antioxidant and cholinergic enzymes. The study concludes that chronic OPs exposure induces oxidative stress which is associated with the related SNP polymorphism. The toxicogenetics of understudied SNPs were examined for the first time to our understanding. The findings may lead to a newer area of investigation on OPs induced health issues and toxicogenetics.

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Oxidative stress, inflammatory settings, and microRNA regulation in the recurrent implantation failure patients with metabolic syndrome

Cited by 40 publications

References 63 publications

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan

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