Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy

Abstract

Background. The aim of study was to determine relationships between functional capacity (NYHA class), left ventricle ejection fraction (LVEF), hemodynamic parameters, and biomarkers of redox state and inflammation in patients with dilated cardiomyopathy (DCM). Methods. DCM patients (n = 109, aged 45.97 ± 10.82 years), NYHA class IIV, and LVEF 2.94 ± 7.1% were studied. Controls comprised age-matched healthy volunteers (n = 28). Echocardiography and right heart catheterization were performed. Serum activities of superoxide dismutase isoenzymes (MnSOD and CuZnSOD), concentrations of uric acid (UA), malondialdehyde (MDA), and C-reactive protein (hs-CRP) were measured. Results. MnSOD, UA, hs-CRP, and MDA were significantly higher in DCM patients compared to controls. Except MDA concentration, above parameters were higher in patients in III-IV NYHA class or with lower LVEF. hsCRP correlated with of MnSOD (P < 0.05) and CuZnSOD activity (P < 0.01). Both isoenzymes positively correlated with mPAP and pulmonary capillary wedge pressure (MnSOD, resp., P < 0.01 and P < 0.05 and CuZnSOD P < 0.05; P < 0.05). UA positively correlated with MnSOD (P < 0.05), mPAP (P < 0.05), and PVRI (P < 0.05). The negative correlation between LVEF and UA (P < 0.01) was detected. Conclusion. There are relationships among the severity of symptoms of heart failure, echocardiographic hemodynamic parameters, oxidative stress, and inflammatory activation. Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.

Uric Acid, Oxidative Stress and Inflammation in Chronic Heart Failure with Reduced Ejection Fraction

“…The significant relationship in between sUA and LVEF found in the present study (r = -0.24, p=0.048) has also been demonstrated in several CHF studies (24,27,28). sUA level was related to NT-proBNP levels (24,26). Our data was similar to OPT-CHF trial results (29).…”

“…PON-1, a HDL-associated glycoprotein with antioxidant function, was reduced in CHF patients. Lower levels of PON-1 activity were also found in patients with idiopathic dilated cardiomyopathy and CHF (24). The diminished PON-1 activity in CHF with low EF was a marker of worse prognosis, predicting a higher risk of incident long-term adverse events (34).…”

“…sUA was higher in patients with increased LV filling pressures (8.6 ± 2.2 mg/dL in patients with E/e'ratio ≥ 13 vs 7.3 ± 1.4 mg/dL, p=0.08). The relationship between sUA and the hemodynamic compromise in CHF was demonstrated invasively and non-invasively by the measurement of E/A ratio of the mitral inflow at echocardiography (2,6,22,23,24). sUA correlated with severe diastolic dysfunction defined echocardiographically by restrictive mitral filling pattern (25).…”

Effects of aerobic exercise on antioxidants in rat models with cardiomyopathy

“…Oxidative stress plays a major role in the biochemical and pathophysiological changes associated with cardiomyopathy. Cardiomyopathy has been shown to be associated with increased oxidative stress, as evidenced by an increase in myocardial thiobarbituric acid-reactive substances (TBARS) and depletion of myocardial endogenous antioxidants such as C-reactive protein, superoxide dismutase (SOD), catalase, glutathione, and glutathione peroxidase [4][5][6]. Similar observations have been made previously in different studies using similar models [7,8].…”

Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects

“…We, therefore, measured the serum concentrations of indices of oxidative stress such as SOD, GRx and MDA and proinflammatory cytokines such as IL-1β and TNF-α. Serum concentration of markers of oxidative stress and proinflammatory cytokines can predict the severity of heart failure as they were correlated with the severity of it (Wojciechowska et al 2014;Zarrouk-Mahjoub et al 2016). Our findings show that the present model of heart failure is associated with increased oxidative stress and release of proinflammatory cytokines.…”