1992
DOI: 10.1016/0891-5849(92)90165-d
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Oxidative stress on mouse embryo development in vitro

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Cited by 87 publications
(49 citation statements)
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“…Therefore, IGF-I may promote embryonic development by an anti-apoptotic effect instead of increasing HIF-1α expression. Embryos cultured in vitro under low (5 %) oxygen tension have been reported to show higher developmental rates than those cultured under 20 % oxygen in mice [43], cattle [44], and human [23]. These reports indicated that a high oxygen tension during in vitro culture was found to be toxic to mammalian embryos, probably due to the formation of reactive oxygen species (ROS) [45,46].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, IGF-I may promote embryonic development by an anti-apoptotic effect instead of increasing HIF-1α expression. Embryos cultured in vitro under low (5 %) oxygen tension have been reported to show higher developmental rates than those cultured under 20 % oxygen in mice [43], cattle [44], and human [23]. These reports indicated that a high oxygen tension during in vitro culture was found to be toxic to mammalian embryos, probably due to the formation of reactive oxygen species (ROS) [45,46].…”
Section: Discussionmentioning
confidence: 99%
“…Before implantation, the oxygen partial pressure in the lumen of the uterus settles between 20 and 37 mm Hg, regardless of the species of mammals considered [53,54]. However, from in vitro studies, it appears that, inside the cells of the embryo, the oxygen partial pressure is 10 to 5 times lower than outside the cells, so that the induced rate of ROS production is lower than that expected from the external oxygen partial pressure [50]. At implantation, oxygen partial pressure at the level of the cytotrophoblasts is thus of the order of 14 mm Hg, which corresponds to a level of 2% of oxygen in the atmosphere, i.e.…”
Section: Oxygen Partial Pressure As a Factor Of Ros Production Duringmentioning
confidence: 98%
“…It has been reported that oxygen partial pressure displays positive effects on embryo development only within a narrow range and that an oxidative stress can occur, with possibly potential lethal effects, below (slowing down of ATP synthesis) or above this range (direct peroxidation of membranes due to an excess of oxygen and radical chain initiation) [37]. In vitro, deviation of the oxygen partial pressures from the normal can induce oxidative stress and end embryo-toxicity if antioxidant enzymes (AOE) or antioxidant components are not provided [28,50,51]. During in utero embryo development, embryopathies occur, apparently due to oxygen induced ROS production, but in less well characterized circumstances [28,50,52].…”
Section: Oxygen Partial Pressure As a Factor Of Ros Production Duringmentioning
confidence: 99%
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