Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis

Bavunoğlu, İşıl; Genc, Habibe; Konukoğlu, Dildar; Cicekci, Hayriye; Sözer, Volkan; Gelışgen, Remise; Uzun, Hafize

doi:10.3855/jidc.7585

Cited by 32 publications

(29 citation statements)

References 34 publications

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“…C reactive protein has a high sensitivity and specificity in diagnosing sepsis (up to 90% and 68%) and in some studies it seems to be even more reliable than procalcitonin 18. Variations in inflammatory parameters in patients with positive blood cultures have also been linked to different clinical outcomes 19 20. The algorithms used to evaluate the risk of whether a patient is septic are not reliable, with very low sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for bloodstream infections in gynecological cancer

Franza

Costantini

Corrado

et al. 2020

Int J Gynecol Cancer

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ObjectiveInfections are a threat to frail patients as they have a higher risk of developing serious complications from bloodstream pathogens. The aim of this study was to determine which factors can predict or diagnose bloodstream infections in patients with an underlying gynecologic malignancy.Materials and MethodsBetween July 2016 and December 2017, 68 patients visiting the emergency room with an underlying gynecologic malignancy were evaluated. Variables concerning underlying disease, invasive procedures, and laboratory and clinical parameters were analyzed. Patients were divided into three groups based on their blood and urine specimens (positive blood specimens, positive urine specimens, and no positive specimens; patients who had both positive blood and urine specimens were included in the group of positive blood specimens). Risk factors for surgical site infections, recent (<30 days) surgery, and chemotherapy were studied separately.Results68 patients were included in the analysis. Mean age was 55.6 years (standard deviation 14.1). 44% of patients had ovarian cancer, 35% cervical cancer, 12% endometrial cancer, and 9% had other cancer types. In total, 96% of all patients had undergone surgery. Patients who had been treated with chemotherapy were at a higher risk of developing bloodstream infection (P=0.04; odds ratio (OR)=7.9). C reactive protein, bilirubin, and oxygen saturation (SO2) were significantly different between patients with an underlying infection and those who had none. Only C reactive protein maintained its significance in a linear model, with a cut-off of 180 mg/L (linear regression, P=0.03; OR=4).ConclusionsChemotherapy is a risk factor for the development of bloodstream infections in patients with an underlying gynecologic malignancy; C reactive protein could be a useful tool in making this diagnosis.

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Section: Discussionmentioning

confidence: 99%

Risk factors for bloodstream infections in gynecological cancer

Franza

Costantini

Corrado

et al. 2020

Int J Gynecol Cancer

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“…For instance, in endotoxinderived animal and human sepsis models, TNF-α production is rapidly activated and can be measured in the plasma. [15,16] It was shown in a study that TNF-α could be a reliable indicator of severity of aggravation regardless of the etiologic factor of disease and as a prognostic factor. [17] Guo et al [18] found that the TNF-α levels were highest in the early period after injection (30 min to 1 h) in a sepsis model elicited by a lipopolysaccharide injection.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

İlhan

Susam

Gül

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:The aim of this study was to evaluate the therapeutic effects of thalidomide and etanercept on lipopolysaccharide (LPS)-induced sepsis in a rat model. METHODS:Thirty male Wistar Albino rats were divided into 5 groups: Control, LPS, LPS+Thalidomide, LPS+Etanercept, and LPS+Thalidomide+Etanercept. The control group was given a 1 mL intraperitoneal (i.p.) injection of 0.9% saline solution. For endotoxic treatment, the rats were injected with a single i.p. dose of LPS (Escherichia coli 0111:B4 (5 mg/kg). Thalidomide (0.5 mg/ kg) and etanercept (1 mg/kg) were administered i.p. to the therapeutic groups. Hepatic tissue tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) levels were determined by enzyme-linked immunosorbent assay and malondialdehyde (MDA) levels and total oxidant status (TOS) were measured using appropriate methods. RESULTS:In vivo results exhibited elevated liver tissue TNF-α, IL-6, ICAM-1, PDGF, MDA, and TOS levels in the LPS-treated animals compared with the controls. The analysis of liver tissue supported the findings of biochemical alterations and indicated a therapeutic role for thalidomide and etanercept. Treatment of septic animals with these agents resulted in a remarkable decrease in the selected proinflammatory cytokines, angiogenic factors, and reactive oxygen parameters. CONCLUSION:Restoration of cytokine balance and oxidant status to normal levels following treatment with selected therapeutic agents suggests that thalidomide and etanercept can help to avoid the potentially devastating effects of sepsis.

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“…Oxidative stress mediated damage to mitochondrial DNA can lead to a cycle of ROS production and further mitochondrial damage. Also, the antioxidant system becomes completely overwhelmed and eventually cell death occurs, leading to multiple organ dysfunction (7)(8)(9). Recent reviews emphasize the importance of mitochondrialtargeted antioxidants in sepsis (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients

Soltani¹,

Alikiaie²,

Shafiee³

et al. 2021

BLL

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OBJECTIVE: This study aimed to evaluate the effect of Coenzyme Q10 (CoQ10) administration to patients in the early phase of sepsis to determine its effect on the markers of infl ammation and the clinical outcomes of septic patients. BACKGROUND: Previous studies showed that CoQ10 levels were decreased in septic patients and worsening of mitochondrial dysfunction was observed. METHODS: In this randomized controlled trial septic patients (n = 40) received 100 mg CoQ10 twice a day for seven days added to standard treatment of sepsis. As a primary endpoint levels of Interleukin 6 (IL-6), Tumor Necrosis Factor-α (TNF-α), Glutathione peroxidase and malondialdehyde (MDA) were assessed at baseline, third and 7th day after the intervention. Secondary endpoints included assessment of clinical scores and in-hospital mortality. RESULTS: There was no difference in baseline infl ammatory and oxidative injury markers between the groups. TNF-α and MDA levels decreased signifi cantly in the CoQ10 group on the 7th day of the study (P:0.003 for both). There was a signifi cant difference in the in-hospital mortality in the CoQ10 group compared to the control group (P: 0.01). CONCLUSION: These fi ndings suggest that CoQ10 has a positive effect on clinical parameters as well as mitochondrial dysfunction when administered in the early phase of sepsis (Tab. 2, Fig. 1, Ref. 38).

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Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis

Cited by 32 publications

References 34 publications

Risk factors for bloodstream infections in gynecological cancer

Risk factors for bloodstream infections in gynecological cancer

The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients

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