Oxidative stress risk analysis for exposure to diesel exhaust particle-induced reactive oxygen species

Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis

“…Vascular prooxidative effects PM has been shown to exert prooxidative effects in vitro in cell types that are key players in the development of atherosclerotic lesions such as endothelial cells (Bai et al 2001; Hirano et al 2003; Li et al 2006, 2010; Montiel-Davalos et al 2010), macrophages (Goldsmith et al 1998; Hiura et al 1999; Soukup et al 2000; Lee and Kang 2002; Li et al 2004; Chio et al 2007; Ohyama et al 2007) and possibly smooth muscle cells (Sun et al 2008). Indeed, DEP or ambient PM have been reported to increase ROS production in human aortic endothelial cells (Li et al 2010; Montiel-Davalos et al 2010), likely by activation of the endothelial NADPH oxidase (Mo et al 2009) and/or electron leaks in the mitochondrial electron transport complexes (Li et al 2006).…”

Assessing airborne PM-bound arsenic exposure risk in semiconductor manufacturing facilities

“…2A): (i) the nasopharynx (NP), comprising the anterior nose, posterior nasal passages, larynx and mouth; (ii) the tracheobronchial (TB), comprising the airway from the trachea, main bronchi, intrapulmonary bronchi and terminal bronchioles; and (iii) the pulmonary (P), comprising the airway from respiratory bronchioli through alveolar sacs. Liao and Chen [30] and Chio et al [31] have comprehensively described the HRT model framework and the essential model parameters that characterizing the model structure and function. Based on the principle of mass balance, the HRT model varying with particle size range and time to each regional compartment are given by linear dynamic equations (Appendix A for Eqs.…”

Air Pollution, Lipids and Atherosclerosis

“…Several additional in vitro studies support the concept that the pro-oxidative effects induced by air pollutants occur directly in cells of the vasculature such as endothelial cells (Bai et al 2001 ;Hirano et al 2003 ;Li et al 2006Li et al , 2010MontielDavalos et al 2010 ), macrophages (Soukup et al 2000 ;Hiura et al 1999 ;Li et al 2004 ;Ohyama et al 2007 ;Lee and Kang 2002 ;Chio et al 2007 ;Goldsmith et al 1998 ) and possibly smooth muscle cells (Sun et al 2008 ). These pro-oxidative effects are strongly linked to the induction of pro-infl ammatory responses in the same cell types as previously reviewed by Araujo ( 2011 ).…”