Oxidative stress triggers hyperdynamic circulation via central neural activation in portal hypertensive rats

Liu, Hongqun; Alhassan, Noura; Yoon, Ki Tae; Almutlaq, Lamees; Lee, Samuel S.

doi:10.1007/s12072-023-10481-5

Cited by 3 publications

(5 citation statements)

References 24 publications

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“…In bile duct ligation (BDL)-induced cirrhosis in rats, Lee et al [35] found that mesenteric markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS, an index of lipoperoxidation), and malondialdehyde (MDA), are significantly increased. Congruent with these data, our group has also shown that mesenteric myeloperoxidase (MPO) is significantly increased in portal hypertensive rats [9]. Furthermore, the levels of oxidative stress in the mesentery are closely related to circulating proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6.…”

Section: Oxidative Stress In the Humoral Theorymentioning

confidence: 66%

“…We confirmed that H2O2 stimulates Fos expression in PVN (Figure and decreased MAP, a direct index of hyperdynamic circulation. All these data indic that it is the oxidative stress that triggers the hyperdynamic circulation in portal hyp tension [9].…”

Section: Oxidative Stress In Central Neural Dysregulationmentioning

confidence: 94%

“…In cirrhosis, liver function is significantly impaired and therefore antioxidant function is also jeopardized. This is coupled with excess oxidative stress resulting from portal hypertension driven by gastrointestinal congestion and bacterial translocation [9]. The overactivated ROS can damage the intestine structurally and functionally, as increased lipid peroxidation and protein oxidation have been found in the intestinal mucosa of cirrhotic rats [10] and decompensated cirrhotic patients [11].…”

Section: Pathogenic Mechanisms Of Oxidative Stressmentioning

confidence: 99%

“…Cirrhosis and portal hypertension cause hyperdynamic circulation. There are two theories explaining hyperdynamic circulation in subjects with cirrhosis and portal hypertension: the humoral theory and central neural dysregulation [9].…”

Section: Oxidative Stress In Pathogenesis Of Hyperdynamic Circulationmentioning

confidence: 99%

“…The signals originating from receptors in mesentery are relayed via afferent nerves to the central neural system which then dispatches signals to the cardiovascular system via efferent nerves. The integrity of the reflex arc is essential for the regulation of the cardiovascular system [9,41,42]. Portal hypertension causes congestion in the mesentery which activates chemoreceptors and/or baroreceptors in the splanchnic area.…”

Section: Oxidative Stress In Central Neural Dysregulationmentioning

confidence: 99%

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Oxidative Mechanisms and Cardiovascular Abnormalities of Cirrhosis and Portal Hypertension

Liu,

Nguyen,

Hwang

et al. 2023

IJMS

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In patients with portal hypertension, there are many complications including cardiovascular abnormalities, hepatorenal syndrome, ascites, variceal bleeding, and hepatic encephalopathy. The underlying mechanisms are not yet completely clarified. It is well known that portal hypertension causes mesenteric congestion which produces reactive oxygen species (ROS). ROS has been associated with intestinal mucosal injury, increased intestinal permeability, enhanced gut bacterial overgrowth, and translocation; all these changes result in increased endotoxin and inflammation. Portal hypertension also results in the development of collateral circulation and reduces liver mass resulting in an overall increase in endotoxin/bacteria bypassing detoxication and immune clearance in the liver. Endotoxemia can in turn aggravate oxidative stress and inflammation, leading to a cycle of gut barrier dysfunction → endotoxemia → organ injury. The phenotype of cardiovascular abnormalities includes hyperdynamic circulation and cirrhotic cardiomyopathy. Oxidative stress is often accompanied by inflammation; thus, blocking oxidative stress can minimize the systemic inflammatory response and alleviate the severity of cardiovascular diseases. The present review aims to elucidate the role of oxidative stress in cirrhosis-associated cardiovascular abnormalities and discusses possible therapeutic effects of antioxidants on cardiovascular complications of cirrhosis including hyperdynamic circulation, cirrhotic cardiomyopathy, and hepatorenal syndrome.

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Section: Oxidative Stress In the Humoral Theorymentioning

confidence: 66%

Section: Oxidative Stress In Central Neural Dysregulationmentioning

confidence: 94%

Section: Pathogenic Mechanisms Of Oxidative Stressmentioning

confidence: 99%

Section: Oxidative Stress In Pathogenesis Of Hyperdynamic Circulationmentioning

confidence: 99%

Section: Oxidative Stress In Central Neural Dysregulationmentioning

confidence: 99%

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Oxidative Mechanisms and Cardiovascular Abnormalities of Cirrhosis and Portal Hypertension

Liu,

Nguyen,

Hwang

et al. 2023

IJMS

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Hyperdynamic circulation in cirrhosis: a novel gutsy central neuronal mechanism

Shukla

Kale

2023

Hepatol Int

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Potential mechanisms of traditional Chinese medicine in the treatment of liver cirrhosis: a focus on gut microbiota

Sun,

Zhang,

et al. 2024

Front. Microbiol.

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Cirrhosis, a pathological stage that develops from various chronic liver diseases, is characterized by liver fibrosis, pseudolobular formation, and chronic inflammation. When it progresses to the decompensated phase, the mortality rate of cirrhosis can reach 80%. The role of gut microbiota in the progression of liver diseases has received significant attention. Numerous studies have shown that regulating gut microbiota has significant therapeutic effects on preventing and reversing liver cirrhosis. This article reviewed the mechanisms by which gut microbiota influence liver cirrhosis, explaining the effective therapeutic effects of traditional Chinese medicine. Through multi-directional regulation involving signaling pathways, gut microbiota diversity, and restoration of intestinal barrier function, traditional Chinese medicine has been promising in ameliorating liver cirrhosis, providing treatment options and pharmacological guidance for the occurrence and development of liver cirrhosis.

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Oxidative stress triggers hyperdynamic circulation via central neural activation in portal hypertensive rats

Cited by 3 publications

References 24 publications

Oxidative Mechanisms and Cardiovascular Abnormalities of Cirrhosis and Portal Hypertension

Oxidative Mechanisms and Cardiovascular Abnormalities of Cirrhosis and Portal Hypertension

Hyperdynamic circulation in cirrhosis: a novel gutsy central neuronal mechanism

Potential mechanisms of traditional Chinese medicine in the treatment of liver cirrhosis: a focus on gut microbiota

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