Oxidative Therapy Against Cancer

Miguel, Manuel de; Cordero, Mario D.

doi:10.5772/33251

Cited by 3 publications

(1 citation statement)

References 105 publications

(126 reference statements)

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“…Also, the fact that investigated substances contain a lot of nitrogen atoms in their imidazole structure could offer a possibility that substances were metabolized by cells. As the human cell is very complex system, every source that impacts at least one of the intracellular parameters greatly influences the redox equilibria (Cordero and deMiguel 2012). Greater production of free radical species influenced greater production of glutathione, which is in agreement with the nature of GSH and its cellular defense role against disruption of redox equilibria.…”

Section: Discussionsupporting

confidence: 56%

Novel seleno-hydantoin palladium(II) complex – antimigratory, cytotoxic and prooxidative potential on human colon HCT-116 and breast MDA-MB-231 cancer cells

Živanović

Košarić²,

Šmit³

et al. 2017

gpb

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Selenium and palladium containing compounds separately exert multifunctional effects on cells. While selenium containing compounds usually exert antioxidative properties, palladium(II) containing compounds are cytotoxic and prooxidative. Here we investigated biological effects of bicyclic seleno-hydantoin cis-7a-ethyl-5-methyl-5-phenylselanylmethyl-tetrahydro-pyrrolo[1,2-c] imidazole-1,3-dione (Hid-Se), and its palladium(II) complex, trans-bis-(cis-7a-ethyl-5-methyl-5-phenylselanylmethyl-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dionato) palladium(II) chloride ((Hid-Se) 2 Pd) on human colon HCT-116 and breast MDA-MB-231 cancer cell lines. Hid-Se and (Hid-Se) 2 Pd showed prooxidative and cytotoxic character. In all performed experiments (Hid-Se) 2 Pd proved to be more active, i.e. this substance exerted greater prooxidative effect, cytotoxicity and influence on cell migration potential. Even though Hid-Se and (Hid-Se) 2 Pd enhanced migration of HCT-116 cells, very important feature of these substances is the strong antimigratory potential on metastatic MDA-MB-231 cells.

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Section: Discussionsupporting

confidence: 56%

Novel seleno-hydantoin palladium(II) complex – antimigratory, cytotoxic and prooxidative potential on human colon HCT-116 and breast MDA-MB-231 cancer cells

Živanović

Košarić²,

Šmit³

et al. 2017

gpb

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The Impact of ROS and NGF in the Gliomagenesis and their Emerging Implications in the Glioma Treatment

Fanfarillo

Ferraguti

Lucarelli

et al. 2024

CNSNDDT

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Reactive oxygen species (ROS) are highly reactive molecules derived from molecular oxygen (O2). ROS sources can be endogenous, such as cellular organelles and inflammatory cells, or exogenous, such as ionizing radiation, alcohol, food, tobacco, chemotherapeutical agents and infectious agents. Oxidative stress results in damage of several cellular structures (lipids, proteins, lipoproteins, and DNA) and is implicated in various disease states such as atherosclerosis, diabetes, cancer, neurodegeneration, and aging. A large body of studies showed that ROS plays an important role in carcinogenesis. Indeed, increased production of ROS causes accumulation in DNA damage leading to tumorigenesis. Various investigations demonstrated the involvement of ROS in gliomagenesis. The most common type of primary intracranial tumor in adults is represented by glioma. Furthermore, there is growing attention on the role of the Nerve Growth Factor (NGF) in brain tumor pathogenesis. NGF is a growth factor belonging to the family of neurotrophins. It is involved in neuronal differentiation, proliferation and survival. Studies were conducted to investigate NGF pathogenesis's role as a pro- or anti-tumoral factor in brain tumors. It has been observed that NGF can induce both differentiation and proliferation in cells. The involvement of NGF in the pathogenesis of brain tumors leads to the hypothesis of a possible implication of NGF in new therapeutic strategies. Recent studies have focused on the role of neurotrophin receptors as potential targets in glioma therapy. This review provides an updated overview of the role of ROS and NGF in gliomagenesis and their emerging role in glioma treatment.

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Role of Reactive Oxygen Species in Neurodegenerative Diseases

Tripathy

Singh

Banerjee

et al. 2022

Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition)

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The altered redox state leads to oxidative stress through the extravagant synthesis of reactive oxygen species (ROS) and inhibition of the antioxidant system. The high oxygen demand in nervous tissue makes it vulnerable to ROS, and the presence of peroxidation-prone lipid cells worsens the situation. We now understand that oxidative stress plays a role in the pathophysiology of neurodegenerative diseases such as Parkinson's disease, Motor neuron disease, and Alzheimer's disease. In spite of the fact that there is no lasting cure for any of these diseases, antioxidant treatments have been promoted as ways to treat and discourse neurodegenerative diseases. However, the results regarding their efficacy are contradictory. This chapter examines the role played by oxidative stress in the etiology of neurodegenerative diseases and how they lead to brain dysfunction in people. It will later provide an overview of antioxidants as a therapeutic option for oxidative stress-induced damage.

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Oxidative Therapy Against Cancer

Cited by 3 publications

References 105 publications

Novel seleno-hydantoin palladium(II) complex – antimigratory, cytotoxic and prooxidative potential on human colon HCT-116 and breast MDA-MB-231 cancer cells

Novel seleno-hydantoin palladium(II) complex – antimigratory, cytotoxic and prooxidative potential on human colon HCT-116 and breast MDA-MB-231 cancer cells

The Impact of ROS and NGF in the Gliomagenesis and their Emerging Implications in the Glioma Treatment

Role of Reactive Oxygen Species in Neurodegenerative Diseases

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