Oxidized corn oil changes the liver lipid metabolism of broilers by upregulating peroxisome proliferators activate receptor-α

Zhang, Yuqing; Mahmood, Tahir; Wu, Yuqin; Tang, Zhenhai; Wang, Youli; Wu, Wei; Zhou, Huajin; Guo, Yuming; Yuan, Jianmin

doi:10.1016/j.psj.2022.102437

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…As the key metabolic and detoxification organ, the liver is sensitive to heat stress [ 45 , 46 ]. Former studies have indicated that heat stress induces different degrees of liver damage by causing oxidative stress and inflammatory response [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Chitosan Oligosaccharides Alleviate Heat-Stress-Induced Lipid Metabolism Disorders by Suppressing the Oxidative Stress and Inflammatory Response in the Liver of Broilers

Lan

Luo

et al. 2023

Antioxidants

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Heat stress has been reported to induce hepatic oxidative stress and alter lipid metabolism and fat deposition in broilers. Chitosan oligosaccharides (COSs), a natural oligosaccharide, has anti-oxidant, anti-inflammatory, and lipid-lowering effects. This study is conducted to evaluate dietary COS supplementation on hepatic anti-oxidant capacity, inflammatory response, and lipid metabolism in heat-stressed broilers. The results indicate that heat-stress-induced poor (p < 0.05) growth performance and higher (p < 0.05) abdominal adiposity are alleviated by COS supplementation. Heat stress increases (p < 0.05) serum AST and ATL activity, serum and liver MDA, TG, TC, and LDL-C levels, and the expression of hepatic IL-1β, IL-6, SREBP-1c, ACC, and FAS, while it decreases (p < 0.05) serum SOD and CAT activity, liver GSH-Px and SOD activity, and the expression of hepatic Nrf2, GPX1, IL-10, MTTP, PPARα, and CPT1. Nevertheless, COS supplementation decreases (p < 0.05) serum AST and ATL activity, serum and liver MDA, TG, TC, and LDL-C levels, and the expression of hepatic IL-1β, IL-6, SREBP-1c, ACC, and FAS, while it increases (p < 0.05) serum SOD and CAT activity, liver GSH-Px activity, and the expression of hepatic Nrf2, CAT, IL-10, LPL, MTTP, PPARα, and CPT1. In conclusion, COS could alleviate heat-stress-induced lipid metabolism disorders by enhancing hepatic anti-oxidant and anti-inflammatory capacity.

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Section: Discussionmentioning

confidence: 99%

“…Overall, over 95% of fatty acids de novo synthesis is completed in the liver [ 5 ]. Hepatic lipid metabolism affects serum lipid metabolism and abdominal adiposity [ 13 , 45 ]. Moreover, the abdominal adiposity depends on hepatic TG synthesis and TG transports from the liver to extrahepatic tissues.…”

Section: Discussionmentioning

confidence: 99%

Chitosan Oligosaccharides Alleviate Heat-Stress-Induced Lipid Metabolism Disorders by Suppressing the Oxidative Stress and Inflammatory Response in the Liver of Broilers

Lan

Luo

et al. 2023

Antioxidants

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“…To further explore the effect of dietary emulsifiers on the lipid metabolism of broilers, the expression levels of liver lipid metabolism-related genes were measured. Different from mammals, the main source of fat in avian species is de novo synthesis of liver fat [4,50,51]. Acc and Fasn encode key enzymes for de novo fatty acid synthesis [52,53].…”

Section: Effect Of Emulsifier On Liver Lipid Metabolism Of Yellowfeat...mentioning

confidence: 99%

Effects of emulsifiers on lipid metabolism and performance of yellow-feathered broilers

Wang,

Zeng,

Wei

et al. 2024

BMC Vet Res

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Background Reducing production costs while producing high-quality livestock and poultry products is an ongoing concern in the livestock industry. The addition of oil to livestock and poultry diets can enhance feed palatability and improve growth performance. Emulsifiers can be used as potential feed supplements to improve dietary energy utilization and maintain the efficient productivity of broilers. Therefore, further investigation is warranted to evaluate whether dietary emulsifier supplementation can improve the efficiency of fat utilization in the diet of yellow-feathered broilers. In the present study, the effects of adding emulsifier to the diet on lipid metabolism and the performance of yellow-feathered broilers were tested. A total of 240 yellow-feasted broilers (21-day-old) were randomly divided into 4 groups (6 replicates per group, 10 broilers per replicate, half male and half female within each replicate). The groups were as follows: the control group (fed with basal diet), the group fed with basal diet supplemented with 500 mg/kg emulsifier, the group fed with a reduced oil diet (reduced by 1%) supplemented with 500 mg/kg emulsifier, and the group fed with a reduced oil diet supplemented with 500 mg/kg emulsifier. The trial lasted for 42 days, during which the average daily feed intake, average daily gain, and feed-to-gain ratio were measured. Additionally, the expression levels of lipid metabolism-related genes in the liver, abdominal fat and each intestinal segment were assessed. Results The results showed that compared with the basal diet group, (1) The average daily gain of the basal diet + 500 mg/kg emulsifier group significantly increased (P < 0.05), and the half-even-chamber rate was significantly increased (P < 0.05); (2) The mRNA expression levels of Cd36, Dgat2, Apob, Fatp4, Fabp2, and Mttp in the small intestine were significantly increased (P < 0.05). (3) Furthermore, liver TG content significantly decreased (P < 0.05), and the mRNA expression level of Fasn in liver was significantly decreased (P < 0.05), while the expression of Apob, Lpl, Cpt-1, and Pparα significantly increased (P < 0.05). (4) The mRNA expression levels of Lpl and Fatp4 in adipose tissue were significantly increased (P < 0.05), while the expression of Atgl was significantly decreased (P < 0.05). (5) Compared with the reduced oil diet group, the half-evading rate and abdominal fat rate of broilers in the reduced oil diet + 500 mg/kg emulsifier group were significantly increased (P < 0.05), and the serum level of LDL-C increased significantly (P < 0.05)0.6) The mRNA expression levels of Cd36, Fatp4, Dgat2, Apob, and Mttp in the small intestine were significantly increased (P < 0.05). 7) The mRNA expression levels of Fasn and Acc were significantly decreased in the liver (P < 0.05), while the mRNA expression levels of Lpin1, Dgat2, Apob, Lpl, Cpt-1, and Pparα were significantly increased (P < 0.05). Conclusions These results suggest that dietary emulsifier can enhance the fat utilization efficiency of broilers by increasing the small intestinal fatty acid uptake capacity, inhibiting hepatic fatty acid synthesis and promoting hepatic TG synthesis and transport capacity. This study provides valuable insights for the potential use of emulsifier supplementation to improve the performance of broiler chickens.

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“…The peroxisome proliferator-activated receptor alpha ( PPARα )/peroxisome-proliferator-activated receptor coactivator 1α ( PGC-1α ) signaling pathway is considered a key pathway for promoting fatty acid oxidation and enhancing cellular energy metabolism ( Ni et al, 2022 ). The activation of the PPARα/PGC-1α signaling pathway can induce the expression of carnitine palmitoyl transferase 1 ( CPT1 ), acyl-coenzyme oxidase ( ACO ) and Acyl CoA synthase long-chain family member 1 ( ACSL1 ), and under the influence of the coactivator PGC-1α, promote fatty acid β-oxidation ( Grabacka et al, 2016 ; Coleman, 2019 ; Zhang et al, 2023 ). A study also found that cold stimulation at 4°C ± 1°C can activate the PPARα/PGC-1α signaling pathway accompanied by increased protein expression of the key metabolic enzymes in β-oxidation ( Stancic et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Intermittent cold stimulation affects energy metabolism and improves stress resistance in broiler heart

Li,

Wei,

Zhang

et al. 2024

Poultry Science

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Oxidized corn oil changes the liver lipid metabolism of broilers by upregulating peroxisome proliferators activate receptor-α

Cited by 4 publications

References 31 publications

Chitosan Oligosaccharides Alleviate Heat-Stress-Induced Lipid Metabolism Disorders by Suppressing the Oxidative Stress and Inflammatory Response in the Liver of Broilers

Chitosan Oligosaccharides Alleviate Heat-Stress-Induced Lipid Metabolism Disorders by Suppressing the Oxidative Stress and Inflammatory Response in the Liver of Broilers

Effects of emulsifiers on lipid metabolism and performance of yellow-feathered broilers

Intermittent cold stimulation affects energy metabolism and improves stress resistance in broiler heart

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