Oxidized Low-Density Lipoprotein Serum Concentrations and Cardiovascular Morbidity in End Stage of Renal Disease

Abstract

Introduction: Oxidized low-density lipoprotein (ox-LDL) is considered a main biomarker of oxidative stress, a common characteristic in end stage renal disease. We examined the relationship between ox-LDL serum concentrations and cardiovascular disease in permanent hemodiafiltration therapy patients. Methods: Ox-LDL values were measured by ELISA and were corrected for LDL-cholesterol (LDL-C) in 96 participants and in 45 healthy control subjects. We performed chi-square tests and adjusted models for the role of ox-LDL on cardiovascular morbidity including coronary artery disease, left ventricular hypertrophy, systolic, diastolic dysfunction and peripheral arterial disease. Results: ox-LDL/LDL-C values were significantly higher in patients than in control group (p = 0.02), due to increased ox-LDL serum levels rather than to low LDL-C. The unadjusted relationship between high ox-LDL/LDL-C and low ejection fraction was found significant (x2 = 9.04, p = 0.003), although the association with the other cardiovascular manifestations was found non-significant. In the adjusted model for the prediction of systolic cardiac dysfunction, high ox-LDL/LDL-C, old age and non-administration of vitamin D supplementation during dialysis session were found to be significant predictors after adjustment to the confounder. Moreover, the association between systolic cardiac dysfunction and non-administration of vitamin D derivatives during dialysis sessions was found significant (x2 = 6.9, p = 0.008). Conclusions: This study showed a significant association between high ox-LDL and systolic cardiac dysfunction in permanent hemodiafiltration therapy patients. This relationship seems to be influenced by aging and pharmaceutical therapy during dialysis sessions, including vitamin D derivatives.

Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status

“…However, only visual memory function was associated with oxLDL. Another study revealed a significant relationship between high oxLDL levels and cardiac systolic dysfunction in patients on continuous hemodiafiltration [ 44 ]. In the presented study, the highest level of oxLDL was determined in the older people with a high risk of nutrition-related complications, which may be associated with the highest level of oxidative stress and deficiency of antioxidant vitamins in the poor diet of this group of patients.…”

SOD3 and IL-18 Predict the First Kidney Disease-Related Hospitalization or Death during the One-Year Follow-Up Period in Patients with End-Stage Renal Disease

“…Memon et al [27] demonstrated that bacterial lipopolysaccharide (LPS)-induced infection and zymosan-induced inflammation can increase lipoprotein oxidation in animals. Another retrospective study of 96 ESRD patients showed a strong association between high oxidized LDL (ox-LDL) and systolic cardiac dysfunction in ESRD patients treated with permanent hemodiafiltration therapy [28]. Nguyen-Khoa et al [29] revealed that inflammatory processes increase the production of ROS to deplete antioxidants, followed by increases in lipid peroxidation products and ox-LDL.…”

Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure

“…It is also associated with NT-proBNP in young subjects with or without stable coronary artery disease [ 111 ]. High OxLDL levels have been linked to a more spherical left ventricular cavity [ 112 ], and decreasing diastolic and systolic function independent of other inflammatory markers, lifestyle or vascular cardiac structure [ 113 , 114 ]. OxLDL appears to be correlated to HF severity, with plasma OxLDL being significantly higher in severe CHF patients than in control subjects and mild CHF patients [ 115 ].…”