oXirisNet Registry: A Prospective, National Registry on the oXiris Membrane

Abstract

Worldwide, the widespread use of extracorporeal blood purification therapies (EBPTs) is progressively increasing in everyday clinical practice, particularly in critical care settings. The efficacy of EBPTs on removal of inflammatory mediators is already well established in the literature. Nonetheless, clinical research is particularly cumbersome in this setting, and many clinical trials aiming at exploring the effect of EBPTs on outcomes have failed in demonstrating consistent results regarding 28-day- or hospital-mortality rates. In recent years, data emerging from large registries have been increasingly used to provide real-world evidence on the effectiveness, quality, and safety of EBPTs. The philosophy behind this Italian Registry is a renewal of the concept of “clinical research” in the field of EBPTs applied to critically ill, septic patients with or without acute kidney injury. The platform used for the registry – specifically designed for research purposes and fed by clinical data prospectively observed – promotes good practice with a positive and active interaction with the physician/researcher. This interaction has favorable real-time effects for the specific patient, providing “bed-side clinical feedbacks,” similarly to the decision support system. Examples of these issues are bundles reminders, suggestions for drug adjustment according to the extracorporeal clearance, clinical calculator for body mass index, or mechanical ventilation setting. The platform-physician interaction has additional useful effects on the single utilizing center, providing “mid-term, center-specific clinical feedbacks.” These generally consist of clusters of data taken over a certain period, for example, regarding patients’ outcome, microbiological data, or use of disposable for EBPTs.

The absorbing filter Oxiris in severe coronavirus disease 2019 patients: A case series

“…Oxiris is a new generation of CRRT filter of blood purification membrane material, which is modified on the surface of AN69 (polyacrylonitrile) basement membrane and has the functions of supporting renal function, adsorbing endotoxin and removing inflammatory mediators. 12 We observe a sharp decrease of most inflammatory factors (IL-6, IL-1β, IL-8, and IL-10) which extraordinary increased before CRRT, and is in accordance with previous studies. 13 The overall value of PCT and TNF-α showed an upward trend, which is inconsistent with existing studies.…”

Continuous Renal Replacement Therapy with oXiris® Membrane in Severe Ebstein-Barr Virus-Mediated Hemophagocytic Lymphohistiocytosis: A Case Report

“…Similar results, with reduction of vasopressor requirements and inflammatory mediators, were reported in septic shock [7,[10][11][12]. An ICU prospective registry [13] will help better understand the role and indications of CRRT blood purification membranes.…”

Continuous Renal Replacement Therapy in Critically Ill Children in the Pediatric Intensive Care Unit: A Retrospective Analysis of Real-Life Prescriptions, Complications, and Outcomes

“…Unfortunately, we were not able to present data for the entire population of 28 patients who underwent CRRT, but only for the subgroup of 23 patients treated with Prismaflex® machine. Multicenter registries ( 46 ) are certainly required for the observation of larger populations. Duration of follow-up was relatively short, and it is possible that longer observation may reveal different outcomes: it is currently unknown if these would imply improvement of further worsening of renal function of these patients.…”