OxLDL/HDL ratio and its correlation to myeloperoxidase activity in ACS patients

Abstract

Background: Oxidative stress in ACS patients results in oxidation of lipoproteins. Resultant oxLDL (oxidized Low Density Lipoprotein) is a marker for lipid peroxidation. OxLDL/HDL ratio can be used as predictor of oxidative stress and inflammation in atherosclerotic cardiovascular diseases. Myeloperoxidase (MPO), oxidative stress related enzyme, increases in inflammatory conditions. Aim and Objectives: To evaluate oxLDL/HDL ratio in ACS patients. Correlation analysis of oxLDL/HDL ratio to oxidative stress markers, MPO and Malondialdehyde (MDA) were also attempted. Materials and Method: 60 ACS patients from Hospital’s Cardiac Care Unit and 60 controls from Hospital’s Health Checkup were selected. Results: oxLDL and oxLDL/HDL ratio were significantly higher in ACS patients. Significant increase was observed in Myeloperoxidase, MDA, Total cholesterol, Low Density Lipoprotein and Triglycerides in ACS patients. Significant positive correlation was observed between oxLDL/HDL and MPO and also between oxLDL/HDL and MDA. Conclusion: Increase in MPO, oxLDL and oxLDL/HDL ratio in ACS is indicative of the significance of MPO in oxidative damage to lipoproteins in cardiovascular disease (CVD) and in incidence of acute events in CVD. We suggest that oxLDL/HDL ratio and MPO can be used as predictive markers to monitor the precipitation of acute events in CVD.