Oxygen and viruses: a breathing story

Morinet, F.; Parent, M.; Bergeron, Corinne; Pillet, Sylvie; Capron, Claude

doi:10.1099/vir.0.000172

Cited by 14 publications

(9 citation statements)

References 28 publications

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“…Both were associated with lower than average CD4 + counts during the acute phase. is high viral replication phase [8] has been reported to have complex relationships with oxygen effects [92], which may also suggest the twisted CD4 + count trends in response to the LDH and red blood cell in our data. Aerobic endurance is referred to as the functional state of the oxygen AIDS Research and Treatment transport system [93] and has been reported to be reduced in HIV positive patients than negative ones [94][95][96].…”

Section: Discussionsupporting

confidence: 51%

Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Tinarwo

Zewotir

North

2020

AIDS Research and Treatment

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In response to invasion by the human immunodeficiency virus (HIV), the self-regulatory immune system attempts to restore the CD4+ count fluctuations. Consequently, many clinical covariates are bound to adapt too, but little is known about their corresponding new optimal set points. It has been reported that there exist few strongest clinical covariates of the CD4+ count. The objective of this study is to harness them for a streamlined application of multidimensional viewing lens (statistical models) to zoom into the behavioural patterns of the adaptive optimal set points. We further postulated that the optimal set points of some of the strongest covariates are possibly controlled by dietary conditions or otherwise to enhance the CD4+ count. This study investigated post-HIV infection (acute to therapy phases) records of 237 patients involving repeated measurements of 17 CD4+ count clinical covariates that were found to be the strongest. The overall trends showed either downwards, upwards, or irregular behaviour. Phase-specific trends were mostly different and unimaginable, with LDH and red blood cells producing the most complex CD4+ count behaviour. The approximate optimal set points for dietary-related covariates were total protein 60–100 g/L (acute phase), <85 g/L (early phase), <75 g/L (established phase), and >85 g/L (ART phase), whilst albumin approx. 30–50 g/L (acute), >45 g/L (early and established), and <37 g/L (ART). Sodium was desirable at approx. <45 mEq/L (acute and early), <132 mEq/L (established), and >134 mEq/L (ART). Overall, desirable approximates were albumin >42 g/L, total protein <75 g/L, and sodium <137 mEq/L. We conclude that the optimal set points of the strongest CD4+ count clinical covariates tended to drift and adapt to either new ranges or overlapped with the known reference ranges to positively influence the CD4+ cell counts. Recommendation for phase-specific CD4+ cell count influence in adaptation to HIV invasion includes monitoring of the strongest covariates related to dietary conditions (sodium, albumin, and total protein), tissue oxygenation (red blood cells and its haematocrit), and hormonal control (LDH and ALP).

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Section: Discussionsupporting

confidence: 51%

Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Tinarwo

Zewotir

North

2020

AIDS Research and Treatment

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“…pB19-M20 replicated and produced infectious virions in B19V-semipermissive UT7/Epo-S1 cells (29) as well as in human embryonic kidney 293 (HEK293) cells when an adenoviral helper plasmid that expresses the adenoviral E2, E4orf6, and VA genes was provided (52,53). The production of infectious progeny virions from pB19-M20-transfected UT7/Epo-S1 cells was significantly improved when cells were cultured under hypoxia (1% O 2 ) (54), as hypoxia has been shown to enhance B19V replication (55,56). Several full-length genomes of B19V have been sequenced FIG 1 B19V transcription map.…”

Section: B19v Genome Organization and Expressionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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“…18 Influenza viruses are among viruses that oxygen dependent for growth and replication. 19 The chronic hypoxia state and polycythemia in patients with CHD-associated PAH and Eisenmenger syndrome may inhibit virus replication. However, the behavior of SARS-CoV2 with reduced oxygen environments in CHD-associated PAH and severe PAH is unknown.…”

Section: The Chronic Hypoxia Statementioning

confidence: 99%

Pulmonary artery hypertension patients and the coronavirus disease of 2019 (COVID-19): are they protected from severe disease?

et al. 2020

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The coronavirus disease of 2019 (COVID-19) is a current pandemic of viral infection which mainly involves respiratory system and may progress into severe multiple organ dysfunction and mortality. Pulmonary artery hypertension (PAH) is a disease marked by increased mean pulmonary artery pressure and pulmonary vascular resistance due to pulmonary panvascular remodeling. Although rare, the prevalence of PAH is currently escalating in Indonesia due to increased diagnostic capacity and referral, treatment availability and improved survival. Despite chronic cardiac and pulmonary diseases are at increased risk to develop severe COVID-19, patients with PAH are considered to be not in higher risk to develop severe COVID-19. However, whether this population is protected from severe COVID-19 is unclear. There are protective and offensive factors need to be considered in PAH patients in respect to COVID-19. ABSTRAK Penyakit koronavirus 2019 (COVID-19) menjadi infeksi virus pandemik yang terutama melibatkan sistem pernapasan dan dapat menjadi pemberatan menuju disfungsi organ multipel yang berat dan kematian. Hipertensi arteri paru (HAP) merupakan penyakit yang ditandai dengan kenaikan tekanan rerata arteri paru dan tahanan pembuluh darah paru karena remodeling seluruh lapisan pembuluh darah paru. Meskipun jarang, prevalensi HAP saat ini meningkat di Indonesia akibat kenaikan kemampuan diagnosis dan rujukan, ketersediaan obat dan perbaikan angka kesintasan. Meskipun penyakit jantung dan paru kronik mempunyai peningkatan risiko menjadi COVID-19 yang berat, pasien HAP dipertimbangkan tidak mempunyai risiko lebih tinggi mengalami COVID-19 yang berat. Namun, apakah populasi ini terlindungi dari COVID-19 yang berat masih belum jelas. Terdapat faktor-faktor perlindungan dan pemberatan yang perlu dipertimbangkan pada pasien PAH sehubungan dengan COVID-19.

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Oxygen and viruses: a breathing story

Cited by 14 publications

References 28 publications

Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Human Parvoviruses

Pulmonary artery hypertension patients and the coronavirus disease of 2019 (COVID-19): are they protected from severe disease?

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Oxygen and viruses: a breathing story

Cited by 14 publications

References 28 publications

Trends and Adaptive Optimal Set Points of CD4+ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Trends and Adaptive Optimal Set Points of CD4+ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Human Parvoviruses

Pulmonary artery hypertension patients and the coronavirus disease of 2019 (COVID-19): are they protected from severe disease?

Contact Info

Product

Resources

About

Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression