Oxygen availability and blood flow in the temporal lobes during spontaneous epileptic seizures in man

Dymond, Anthony M.; Crandall, Paul H.

doi:10.1016/0006-8993(76)90587-4

Cited by 75 publications

(36 citation statements)

References 14 publications

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“…It has been demonstrated that neurodegenerative diseases produced changes in nitric oxide metabolism and interacts with glutamatergic receptors to produce part of its stimulatory action on the CNS (Dymond & Crandall, 1976;Xavier et al, 2007;Freitas, 2009). The fall in nitrite content, after pretreatment with EO of C. limon, is most readily explained as a consequence of inhibiting formation of radicals, scavenges ROS, and lipid peroxidation products .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Campêlo

Gonçalves

Feitosa³

et al. 2011

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Campêlo

Gonçalves

Feitosa³

et al. 2011

Pharmaceutical Biology

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“…Brain is particularly susceptible to peroxidation due to simultaneous presence of high levels of poly unsaturated fatty acids and iron 23 , which is the target of free radical damage. It has been demonstrated that seizures induced by pilocarpine produces changes in oxidative metabolism and interacts with glutamatergic receptors to produced part of its stimulatory action on the central nervous system [24][25][26][27] . The fall in glutamate content, after pretreatment with lipoic acid, is most readily explained as a consequence of inhibiting their release or increasing their metabolization [28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

Santos

Campêlo

Freitas³

et al. 2011

Arq. Neuro-Psiquiatr.

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Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes. The present research suggests that antioxidant compounds may afford some level of neuroprotection against the neurotoxicity of seizures in cellular level. The objective of the present study was to evaluate the lipoic acid (LA) effects in glutamate and taurine contents in rat hippocampus after pilocarpine-induced seizures. Wistar rats were treated intraperitoneally (i.p.) with 0.9% saline (Control), pilocarpine (400 mg/kg, Pilocarpine), LA (10 mg/kg, LA), and the association of LA (10 mg/kg) plus pilocarpine (400 mg/kg), that was injected 30 min before of administration of LA (LA plus pilocarpine). Animals were observed during 24 h. The amino acid concentrations were measured using high-performance liquid chromatograph (HPLC). In pilocarpine group, it was observed a significant increase in glutamate content (37%) and a decrease in taurine level (18%) in rat hippocampus, when compared to control group. Antioxidant pretreatment significantly reduced the glutamate level (28%) and augmented taurine content (32%) in rat hippocampus, when compared to pilocarpine group. Our findings strongly support amino acid changes in hippocampus during seizures induced by pilocarpine, and suggest that glutamate-induced brain damage plays a crucial role in pathogenic consequences of seizures, and imply that strong protective effect could be achieved using lipoic acid through the release or decrease in metabolization rate of taurine amino acid during seizures. Key words: seizures, pilocarpine, amino acids, hippocampus, glutamate, taurine.Efeitos do ácido lipóico nas concentrações de glutamato e taurina no hipocampo de ratos após convulsões induzidas por pilocarpina RESUMO As convulsões induzidas pela pilocarpina podem ser mediadas através do aumento do estresse oxidativo cerebral e das alterações na concentração dos aminoácidos. O presente estudo sugere que compostos antioxidantes podem produzir neuroproteção contra a neurotoxicidade em nível celular causada pelas convulsões. O objetivo deste estudo foi avaliar os efeitos do ácido lipóico (AL) no conteúdo de glutamato e taurina no hipocampo de ratos durante convulsões induzidas por pilocarpina. Ratos Wistar foram tratados por via intraperitoneal com solução salina 0,9% (controle), pilocarpina (400 mg/kg, pilocarpina), AL (10 mg/kg) e com a associação de AL (10 mg/kg); 30 min após com pilocarpina (400 mg/kg), que foi injetada 30 min após a administração de AL (AL + pilocarpina). Os animais foram observados durante 24 horas. As concentrações de aminoácidos foram

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“…Studies have shown that neurodegenerative diseases generate changes in nitric oxide metabolism, and interact with glutamate receptors to produce part of its stimulating action on the central nervous system (CNS) (Dymond & Crandall, 1976;Freitas, 2009;Silva et al, 2006;Souza et al, 2007;Xavier et al, 2007). In the nervous system, NO participates in various signaling processes, in tissue defense against pathogens, but is also a harmful agent when in excess, evoking oxidative reactions/reducing, producing RNS (Freitas, 2009;Migliorea & Coppedèb, 2009;Sueishi et al, 2011).…”

Section: Sod Activity In Mice Hippocampus Treated With P-cymene Acutelymentioning

confidence: 99%

Evaluation ofp-cymene, a natural antioxidant

Oliveira

Carvalho

Costa

et al. 2014

Pharmaceutical Biology

123

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Context: Several studies have demonstrated that essential oils and their major components have antioxidant activity. p-Cymene is a monoterpene and a major constituent of essential oils of various species of plants. Objective: This paper evaluated the antioxidant potential of p-cymene in the hippocampus of mice by determining the levels of thiobarbituric acid reactive substances (TBARS), nitrite content, and activity of catalase (CAT) and superoxide dismutase (SOD). Materials and methods: Swiss mice were intraperitoneally treated with 0.05% Tween 80 dissolved in 0.9% saline solution, ascorbic acid 250 mg/kg, and p-cymene at doses of 50, 100, and 150 mg/kg, respectively. After treatment, all groups were observed for 24 h, afterwards, the groups were euthanized for removal of the brain and dissection of the hippocampus. Results:The results of treatment with p-cymene were a significant decrease in lipid peroxidation and nitrite content at a dose of CYM 50: 65.54%, CYM 100: 73.29%, CYM 150: 89.83%, and CYM 50: 71.21%; CYM 100: 68.61% and CYM 150:67%, respectively, when compared with the control group. The results showed that at all tested doses, p-cymene produces an increase in SOD and catalase activity significantly at a dose of CYM 50: 22.7%, CYM 100: 33.9%, CYM 150: 63.1%, and CYM 50: 119.25%, CYM 100: 151.83% and CYM 150: 182.70%, respectively, when compared with the vehicle-treated group. Discussion and conclusion: The result of this study shows that p-cymene has an antioxidant potential in vivo and may act as a neuroprotective agent in the brain. This compound may present a new strategy in the development of treatment for many diseases in which oxidative stress plays an important pathophysiological role.

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Oxygen availability and blood flow in the temporal lobes during spontaneous epileptic seizures in man

Cited by 75 publications

References 14 publications

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

Evaluation ofp-cymene, a natural antioxidant

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