Oxygen self-sufficient photodynamic therapy

Wei, Fangmian; Rees, Thomas W.; Liao, Xinxing; Ji, Liang‐Nian; Chao, Hui

doi:10.1016/j.ccr.2020.213714

Cited by 87 publications

(52 citation statements)

References 142 publications

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“…In any case, another important and negative consequence of PDT to have in mind is hypoxia, which often occurs in the tumour microenvironment [181][182][183][184]. Oxygen self-sufficient [185] and oxygen-boosted PDT could be the solutions. Some strategies involve oxygen carriers or generators, such as nanoparticles based on perfluorocarbon or manganese dioxide (MnO 2 ) and haemoglobin-based nanostructures [186].…”

Section: Pdt Mechanismsmentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

190

140

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Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources. The key issues and main conclusions are summarized, including ways and means to improve therapy and outcomes. Due to the broad scope of this work and it being the first time that a compendium of the latest reviews has been performed for PDT, it may be of interest to a wide audience.

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Section: Pdt Mechanismsmentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

190

140

View full text Add to dashboard Cite

show abstract

“…Hence, PTT is regarded as an efficient treatment for tumors. As compared to PDT, in which the participation of oxygen is indispensable, [ 25 ] PTT is believed to be more suitable for tumor therapy as most malignant tumors are hypoxic. Till now, various photothermal nanomaterials have been evaluated for PTT, such as metal nanoparticles, [ 26 ] light‐absorbing polymers, [ 27 ] 2D nanomaterials, [ 28 ] black phosphorus‐based nanomaterials, [ 29 ] and pigment‐incorporated nanomaterials.…”

Section: Therapeutic and Diagnostic Mechanismsmentioning

confidence: 99%

Functional Nanomaterials Based on Self‐Assembly of Endogenic NIR‐Absorbing Pigments for Diagnostic and Therapeutic Applications

2022

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Figure 2. Photothermal nanoparticles based on self-assembly of BV and peptide. A) Construction of the ZB NPs and ZBMn NPs by self-assembly. B) Absorption spectra of BV, ZB NPs, and ZBMn NPs in aqueous solutions. C) SEM image of the ZB NPs. D) SEM image of the ZBMn NPs. E) Temperature elevation of the solutions containing ZB NPs and ZBMn NPs under the same irradiation (730 nm, 0.3 W cm −2). Reproduced with permission. [21]

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“…Second, a number of biological barriers including limited endothelial permeability and intratumoral diffusion of the therapeutic nanoparticles may result in poor tumor penetration of polyprodrug nanomedicines. [ 16–172 ] Third, the difficulty in tuning the size, shape, surface properties, ...…”

Section: Summary Challenges and Outlookmentioning

confidence: 99%

“…The hypoxic tumor microenvironment has been a major concern in PDT as oxygen is necessary for the generation of ROS by most photosensitizers. [ 128–133 ] By combining SPNs with manganese dioxide (MnO 2 ) nanosheets, Pu and coworkers synthesized hybrid semiconducting nanoparticles (SPN‐Ms) that produced oxygen in hypoxic tumors. [ 125 ] As compared with the SPNs without MnO 2 coatings (SPN‐0), SPN‐Ms generated 2.68‐fold more 1 O 2 under NIR laser irradiation, which resulted in significant growth inhibition of hypoxic tumors.…”

Section: Polyprodrug Nanomedicines For Various Therapeutic Modalities...mentioning

confidence: 99%

Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy

Yang

et al. 2021

Advanced Materials

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Nanomedicines have the potential to provide advanced therapeutic strategies in combating tumors. Polymer‐prodrug‐based nanomedicines are particularly attractive in cancer therapies owing to the maximum drug loading, prolonged blood circulation, and reduced premature leakage and side effects in comparison with conventional nanomaterials. However, the difficulty in precisely tuning the composition and drug loading of polymer–drug conjugates leads to batch‐to‐batch variations of the prodrugs, thus significantly restricting their clinical translation. Polyprodrug nanomedicines inherit the numerous intrinsic advantages of polymer–drug conjugates and exhibit well‐controlled composition and drug loading via direct polymerization of therapeutic monomers, representing a promising nanomedicine for clinical tumor therapies. In this review, recent advances in the development of polyprodrug nanomedicines are summarized for tumor elimination. Various types of polyprodrug nanomedicines and the corresponding properties are first summarized. The unique advantages of polyprodrug nanomedicines and their key roles in various tumor therapies are further highlighted. Finally, current challenges and the perspectives on future research of polyprodrug nanomedicines are discussed.

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Oxygen self-sufficient photodynamic therapy

Cited by 87 publications

References 142 publications

Photodynamic Therapy: A Compendium of Latest Reviews

Photodynamic Therapy: A Compendium of Latest Reviews

Functional Nanomaterials Based on Self‐Assembly of Endogenic NIR‐Absorbing Pigments for Diagnostic and Therapeutic Applications

Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy

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