Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone

Okunieff, Paul; Hoeckel, Michael; Dunphy, Eamonn P.; Schlenger, Karlheinz; Knoop, Claudia; Vaupel, Peter

doi:10.1016/0360-3016(93)90280-9

Cited by 144 publications

(74 citation statements)

References 29 publications

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“…In a series of experimental and clinical studies, Vaupel and others showed definitively that measurements of pO 2 by polarographic microelectrodes provided useful criteria for predicting the response of tumors to radiation therapy. [36][37][38][39][40][41][42] According to Swartz, 43 these results are remarkable in two ways:…”

Section: Tumor Hypoxia Increases the Resistance To Radiotherapymentioning

confidence: 99%

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004

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This review paper attempts to provide an overview of the principles and techniques that are often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the potential of such methods and illustrates they have been successfully applied to measure oxygen tension, an essential parameter of the tumor microenvironment. To help the reader understand the motivation for carrying out these measurements, the importance of tumor hypoxia is first discussed: the basic issues of why a tumor is hypoxic, why these hypoxic microenvironments promote processes driving malignant progression and why hypoxia dramatically influences the response of tumors to cytotoxic treatments will be explained. The different methods that have been used to estimate the oxygenation in tumors will be reviewed. To introduce the basics of EPR oximetry, the specificity of in vivo EPR will be discussed by comparing this technique with NMR and MRI. The different types of paramagnetic oxygen sensors will be presented, as well as the methods for recording the information (EPR spectroscopy, EPR imaging, dynamic nuclear polarization). Several applications of EPR for characterizing tumor oxygenation will be illustrated, with a special emphasis on pharmacological interventions that modulate the tumor microenvironment. Finally, the challenges for transposing the method into the clinic will also be discussed.

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Section: Tumor Hypoxia Increases the Resistance To Radiotherapymentioning

confidence: 99%

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004

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“…Conclusive experimental and clinical research demonstrates the impact of hypoxic tumour cells upon the therapeutic outcome of cancer radiotherapy and some chemotherapy. [1][2][3][4][5] Hypoxic cells are approximately three times more radio-resistant than normoxic cells which is thought to result primarily from the ability of oxygen to react with, and chemically modify the initial radiationinduced DNA radicals. Although less clinical evidence is available regarding the impact of hypoxia on the failure of chemotherapy there is direct evidence that hypoxic cells within tumour xenografts are refractive to clinically relevant chemotherapeutic agents and it is reasonable to infer that the quiescent nature of hypoxic cells may render them insensitive to agents that target rapidly dividing cells.…”

Section: Introductionmentioning

confidence: 99%

Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours

et al. 2002

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“…For this reason, and to support the development of SR-4554 as a hypoxia probe, the relationship between '9F-MRS retention and tumour pO2 (measured directly by Eppendorf oxygen needle electrode) was assessed in several transplantable rodent tumours in vivo. The oxygen electrode method of determining pO2 was chosen for comparison as the technique directly measures pO2 and is currently being used clinically to determine tumour oxygenation (Kolstad, 1968;Vaupel et al, 1991;Okunieff et al, 1993;Rampling et al, 1994).…”

Section: Resultsmentioning

confidence: 99%

“…Such measurements have been used clinically to investigate the effect of tumour oxygenation on the radiocurability of human tumours (Kolstad 1968;Gatenby et al, 1988;Okunieff et al, 1993). In addition, a good correlation between the radiobiological hypoxic fraction and oxygen electrode measurements has been reported in various mouse tumour models to date (Horsman et al, 1994;Nordsmark et al, 1995).…”

mentioning

confidence: 99%

“…Currently, the oxygen tension (pO2) within tumours can be measured directly by fine needle oxygen electrodes (Kolstad, 1968;Vaupel et al, 1992;Okunieff et al, 1993;Horsman et al, 1994;Brizel et al, 1995;Nordsmark et al, 1995). Such measurements have been used clinically to investigate the effect of tumour oxygenation on the radiocurability of human tumours (Kolstad 1968;Gatenby et al, 1988;Okunieff et al, 1993).…”

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confidence: 99%

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The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554

Aboagye¹,

Maxwell²,

Horsman³

et al. 1998

Br J Cancer

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Summary The relationship between two methods of assessing tumour oxygenation in vivo, namely oxygen electrode measurement and magnetic resonance spectroscopy (MRS) of the fluorinated 2-nitroimidazole SR-4554, was investigated. Using three tumour models (two sites), no linear correlation was observed between 19F retention index and P02 parameters (r < 0.3). Substantial retention of SR-4554 (19F retention index > 0.5) was, however, associated with low tumour P02 (% P02 < 5 mmHg = 60%). Depending on the P02 parameters used, SR-4554 administration was shown to produce either a significant or a non-significant increase in tumour oxygenation. We conclude that measurement of SR-4554-related compound(s) by 19F-MRS has the potential to detect clinically relevant levels of tumour hypoxia.

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Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone

Cited by 144 publications

References 29 publications

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours

The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554

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