Oxygen Tensions in Normal and Ischemic Tissues During Hyperbaric Therapy

Ackerman, Norman B.

doi:10.1001/jama.1966.03110250094027

Cited by 19 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The physiologic effects of HBO are manifold. J) At 2.5 AT a) exposure results in a 10-to 15-fold increase of blood oxygen transport (17), which is obviously beneficial to tissues with impaired microcirculation. 2) Vasoconstriction is another, equally important, effect of HBO.…”

Section: Resultsmentioning

confidence: 99%

Hyperbaric Oxygen in Diabetic Gangrene Treatment

et al. 1987

View full text Add to dashboard Cite

We treated a group of 18 hospitalized adult diabetic patients (all with retinopathy, 17 with symptomatic neuropathy, and 6 with macroangiopathy) presenting with gangrenous lesions of the foot by a combined regime consisting of strict metabolic control, daily debridement of necrotic tissues, and daily hyperbaric oxygen (HBO) treatments given in a multiplace oxygen chamber. Another group of 10 adult subjects with comparable foot lesions (all with retinopathy, 9 with symptomatic neuropathy, and 4 with macroangiopathy) was treated in exactly the same way except for HBO. In the test treatment group, 16 patients were healed, and the remaining 2 showed no improvement and later underwent amputation. The number of HBO treatments required for healing was significantly related to the size of gangrenous lesions. In the non-HBO-treated group, only 1 patient improved, 5 of 10 showed no change, and 4 of 10 worsened until leg amputation was unavoidable. Comparison of the two groups by chi 2-test revealed a highly significant difference (P = .001). In practical terms, HBO treatment drastically reduced leg amputations in patients so treated in the last 3 yr compared with earlier and current figures for patients not receiving HBO treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Hyperbaric Oxygen in Diabetic Gangrene Treatment

et al. 1987

View full text Add to dashboard Cite

show abstract

“…HBOT has been shown to increase the oxygen content of plasma [16] and body tissues [17] and can even normalize oxygen levels in ischemic tissue [18]. In fact, the amount of oxygen delivered by HBOT at 3.0 ATA and 100% oxygen is able to keep tissue viable even without oxygen input from circulating hemoglobin [17].…”

Section: Overview Of Hyperbaric Oxygen Therapymentioning

confidence: 99%

Hyperbaric oxygen therapy may improve symptoms in autistic children

Rossignol

Rossignol²

2006

Medical Hypotheses

View full text Add to dashboard Cite

“…A hermetic chamber is used to pressurize the inspired oxygen. HBO treatment increases plasma concentrations of dissolved oxygen, and this effect may normalize or even increase oxygen tensions to hyperoxic levels in ischemic tissue [1,2]. HBO is a useful modality for treatment of diseases in which tissue oxygen availability is decreased, such as osteoradionecrosis, compromised skin grafts, carbon monoxide poisoning, and acute traumatic ischemia (e.g.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen and Thrombolysis in Myocardial Infarction: The ‘HOT MI’ Randomized Multicenter Study

Stavitsky

Shandling²,

Ellestad³

et al. 1998

Cardiology

View full text Add to dashboard Cite

In a previous pilot study, we demonstrated that adjunctive treatment with hyperbaric oxygen (HBO) appears to be feasible and safe in patients with acute myocardial infarction (AMI) and may result in an attenuated rise in creatine phosphokinase (CPK), more rapid resolution of pain and ST changes. This randomized multicenter trial was organized to further assess the safety and feasibility of this treatment in human subjects. Patients with an AMI treated with recombinant tissue plasminogen activator (rTPA) or streptokinase (STK), were randomized to treatment with HBO combined with either rTPA or STK, or rTPA or STK alone. An analysis included 112 patients, 66 of whom had inferior AMIs (p = NS). The remainder of the patients had anterior AMIs. The mean CPK at 12 and 24 h was reduced in the HBO patients by approximately 7.5% (p = NS). Time to pain relief was shorter in the HBO group. There were 2 deaths in the control and 1 in those treated with HBO. The left ventricle ejection fraction (LVEF) on discharge was 51.7% in the HBO group as compared to 48.4% in the controls (p = NS). The LVEF of the controls was 43.4 as compared to 47.6 for those treated, approximately 10% better (no significant difference). Treatment with HBO in combination with thrombolysis appears to be feasible and safe for patients with AMI and may result in an attenuated CPK rise, more rapid resolution of pain and improved ejection fractions. More studies are needed to assess the benefits of this treatment.

show abstract

Oxygen Tensions in Normal and Ischemic Tissues During Hyperbaric Therapy

Cited by 19 publications

References 7 publications

Hyperbaric Oxygen in Diabetic Gangrene Treatment

Hyperbaric Oxygen in Diabetic Gangrene Treatment

Hyperbaric oxygen therapy may improve symptoms in autistic children

Hyperbaric Oxygen and Thrombolysis in Myocardial Infarction: The ‘HOT MI’ Randomized Multicenter Study

Contact Info

Product

Resources

About