Oxygen Toxicity in Newborns

Bracci, Rodolfo; Perrone, Serafina; Vento, Máximo; Buonocore, Giuseppe

doi:10.1007/978-3-319-18159-2_180-1

Cited by 2 publications

(2 citation statements)

References 99 publications

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“…Eryptosis is a coordinated, programmed cell death that allows to eliminate defective erythrocytes. [13,14] Xenobiotics, small endogenous molecules, osmotic shock, energy depletion, oxidative stress, and sudden changes in temperature activate the kinase cascade that leads to cell death. For example, Janus-activated kinase, casein kinase, and p38 kinase eryptosis, while have been shown to induce cell membrane rupture, [15,16] while AMP-activated kinase inhibits erythosis.…”

Section: Superoxide Anion (Omentioning

confidence: 99%

“…[ 18 ] Erythrocyte membranes are highly permeable to free radicals, and thanks to their high antioxidant intracellular activity, red cells are considered free radicals scavengers that provide antioxidant protection to tissues from free radicals‐induced damage. [ 13 ] In fact, red blood cells own a wide array of antioxidant factors, such as superoxide dismutase, catalase, glutathione peroxidase, and the chemical activities of nonenzymatic antioxidants, such as reduced GSH, thioredoxins, vitamin C, vitamin E, and sulfhydryl groups of proteins. Nonetheless, if the organism lacks antioxidant defenses or is subject to an overload of free radicals, oxidative damage may arise.…”

Section: Introductionmentioning

confidence: 99%

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Molecular mechanisms of oxidative stress‐related neonatal jaundice

Perrone

Lembo

Giordano

et al. 2023

J Biochem & Molecular Tox

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Oxidative stress is a pathological condition characterized by an overload of oxidant products, named free radicals, which are not well counteracted by antioxidant systems. Free radicals induce oxidative damage to many body organs and systems. In neonatal red blood cells, free-radical mediated-oxidative stress leads to eryptosis, a suicidal death process of erythrocytes consequent to alteration of cell integrity.Neonatal red blood cells are targets and at the same time generators of free radicals through the Fenton and Haber-Weiss reactions. Enhanced eryptosis in case of oxidative stress damage may cause anemia if the increased loss of erythrocytes is not enough compensated by enhanced new erythrocytes synthesis. The oxidative disruption of the red cells may cause unconjugated idiopathic hyperbilirubinemia in neonates. High levels of bilirubin are recognized to be dangerous for the central nervous system in newborns, however, many studies have highlighted the antioxidant function of bilirubin. Recently, it has been suggested that physiologic concentration of bilirubin correlates with higher antioxidant status while high pathological bilirubin levels are associated with pro-oxidants effects. The aim of this educational review is to provide an updated understanding of the molecular mechanisms underlying erythrocyte oxidant injury and its reversal in neonatal idiopathic hyperbilirubinemia.

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Section: Superoxide Anion (Omentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms of oxidative stress‐related neonatal jaundice

Perrone

Lembo

Giordano

et al. 2023

J Biochem & Molecular Tox

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Improvised bubble continuous positive airway pressure ventilation use in neonates in resource-limited settings: a systematic review and meta-analysis

Usman

Farouk

Tsiga-Ahmed

et al. 2022

Journal of Perinatal Medicine

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Objectives In the face of limited fiscal and technical resources, improvised methods have been used to provide effective and sustainable ventilatory support in low-resource settings to reduce neonatal mortality associated with respiratory complications. This study assessed the use of improvised bubble continuous positive airway pressure (ibCPAP) ventilation among neonates with respiratory complications and determined its effect on neonatal outcomes in low- and middle-income countries (LMICs). Content Hospital-based studies conducted between 2010 and 2020 in LMICs were reviewed. Rayyan® software for systematic review was used for screening and article selection. We used Stata® Statacorp Texas USA software to estimate pooled prevalence, proportion estimates, weighted mean differences and 95% Confidence Interval (CI), using the random effects model. Summary A total of 193 articles were generated and 125 were reviewed. Thirteen articles with 806 neonates on ibCPAP ventilation were included. The pooled prevalence of ibCPAP use was 7.0% (95% CI: 3.0%–13.0%). There was a significant difference in mean oxygen saturation before and after ibCPAP use (−1.34% [95% CI: −1.65% to −1.02%, p<0.01). The duration of oxygen requirement among neonates on ibCPAP was 6.5 hours less than controls (0.27 days [95%CI: −0.49 to −0.05, p<0.01). Outlook IbCPAP had no effect on the respiratory rate, duration of admission, mortality and survival. IbCPAP use in LMIC hospitals is low and its use improved oxygen saturation and duration on oxygen among the neonates, but had no impact on length of stay, respiratory rate, mortality or survival.

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Oxygen Toxicity in Newborns

Cited by 2 publications

References 99 publications

Molecular mechanisms of oxidative stress‐related neonatal jaundice

Molecular mechanisms of oxidative stress‐related neonatal jaundice

Improvised bubble continuous positive airway pressure ventilation use in neonates in resource-limited settings: a systematic review and meta-analysis

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