Oxygenation Status in Normal Tissues, Pathological Tissues and Malignant Tumors: A pO2 Database Based on Electron Paramagnetic Resonance (EPR) Oximetry Measurements

Gallez, Bernard

doi:10.1007/s00723-021-01358-7

Cited by 12 publications

(19 citation statements)

References 216 publications

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“…Above this value of 10 mmHg, further increase in pO 2 does not further enhance the radiosensitivity (Figure 3). The effect of tumor hypoxia on the response to a treatment by ionizing radiation has been demonstrated in a multitude of experimental preclinical studies [reviewed in (Vaup el et al, 2021) and (Gallez, 2021)]. In a series of clinical studies in the early nineties, using pO 2 measurements with microelectrodes, P. Vaupel and others definitively demonstrated that tumor hypoxia was predicting the response of tumors to radiation therapy (Gatenby et al, 1988;Höckel et al, 1993a;Höckel et al, 1993b;Okunieff et al, 1993;Stone et al, 1993;Höckel et al, 1996;Fyles et al, 1998;Knocke et al, 1999;Höckel and Vaupel, 2001;Rudat et al, 2001;Nordsmark et al, 2005;Vaup el et al, 2021).…”

Section: Hypoxia As Factor Of Resistance To Therapymentioning

confidence: 99%

“…compounds had profound effect on tumor oxygenation status and were further characterized for their effect on tumor hemodynamics and potential radiosensitizing properties (Gallez, 2021). The increase in tumor oxygenation observed after pre-treatment with nicotinate derivatives (xanthinol nicotinate or benzylnicotinate) and nitrosocaptopril significantly increased the tumor response to irradiation (Hou et al, 2010;Segers et al, 2010).…”

Section: Decreasing Tumor Hypoxia By Improving the Oxygen Deliverymentioning

confidence: 99%

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The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

Gallez

2022

Front. Pharmacol.

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Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness, metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor progression and resistance to radiotherapy, chemotherapy and immunotherapy, multiple approaches have emerged to target tumor hypoxia. It includes among others pharmacological interventions designed to alleviate tumor hypoxia at the time of radiation therapy, prodrugs that are selectively activated in hypoxic cells or inhibitors of molecular targets involved in hypoxic cell survival (i.e., hypoxia inducible factors HIFs, PI3K/AKT/mTOR pathway, unfolded protein response). While numerous strategies were successful in pre-clinical models, their translation in the clinical practice has been disappointing so far. This therapeutic failure often results from the absence of appropriate stratification of patients that could benefit from targeted interventions. Companion diagnostics may help at different levels of the research and development, and in matching a patient to a specific intervention targeting hypoxia. In this review, we discuss the relative merits of the existing hypoxia biomarkers, their current status and the challenges for their future validation as companion diagnostics adapted to the nature of the intervention.

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Section: Hypoxia As Factor Of Resistance To Therapymentioning

confidence: 99%

Section: Decreasing Tumor Hypoxia By Improving the Oxygen Deliverymentioning

confidence: 99%

The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

Gallez

2022

Front. Pharmacol.

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“…We carried out a series of studies that are still ongoing, most recently focused especially on direct clinical applications. (See also the paper in this special issue by Bernard Gallez [2] that summarizes other aspects of this topic. )…”

Section: Measuring Oxygen-dependent Phenomena In Specific Compartments/ Organs/diseases To Study Physiology and Pathophysiologymentioning

confidence: 99%

“…The methodology that was employed was based on the impact of the paramagnetic oxygen molecule on EPR spectra of all paramagnetic materials, as laid out by others in previous publications [3][4][5]. There are several different experimental approaches to utilize this phenomenon, including impact on the overall line width, impact on the resolution of hyperfine structure, and impact on relaxation times 58,366 .…”

Section: Development Of Oxygen Sensitive Materials and Systemsmentioning

confidence: 99%

“…We made several studies in animals using India ink, especially because of its potential to be used in human subjects without a need to go through the long and expensive FDA process 175,207,200,223,225 . Our studies with India ink built upon the extensive studies of India ink pioneered by Bernard Gallez [2]. Based on the successful experience in animals we then carried out pilot studies in human subjects who had preexisting India ink in their skin from tattoos.…”

Section: Development Of Oxygen Sensitive Materials and Systemsmentioning

confidence: 99%

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History of EPR Studies from the H. M. Swartz Laboratories: Part 3—EPR Oximetry

Swartz

2022

Appl Magn Reson

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Hand‐held electron spin resonance scanner for subcutaneous oximetry using OxyChip

Almog,

Zgadzai,

Kuppusamy

et al. 2024

Magnetic Resonance in Med

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PurposeElectron spin resonance (ESR) is used to measure oxygen partial pressure (pO2) in biological media with many clinical applications. Traditional clinical ESR involves large magnets that encompass the subject of measurement. However, certain applications might benefit from a scanner operating within local static magnetic fields. Our group recently developed such a compact scanner for transcutaneous (surface) pO2 measurements of skin tissue. Here we extend this capability to subsurface (subcutaneous) pO2 measurements and verify it using an artificial tissue emulating (ATE) phantom.MethodsWe introduce a new scanner, tailored for subcutaneous measurements up to 2 mm beneath the skin's surface. This scanner captures pulsed ESR signals from embedded approximate 1‐mm oxygen‐sensing solid paramagnetic implant, OxyChip. The scanner features a static magnetic field source, producing a uniform region outside its surface, and a compact microwave resonator, for exciting and receiving ESR signals.ResultsESR readings derived from an OxyChip, positioned approximately 1.5 mm from the scanner's surface, embedded in ATE phantom, exhibited a linear relation of 1/T2 versus pO2 for pO2 levels at 0, 7.6, 30, and 160 mmHg, with relative reading accuracy of about 10%.ConclusionThe compact ESR scanner can report pO2 data in ATE phantom from an external position relative to the scanner. Implementing this scanner in preclinical and clinical applications for subcutaneous pO2 measurements is a feasible next phase for this development. This innovative design also has the potential to operate in conjunction with artificial skin graft for wound healing, combining therapeutic and pO2 diagnostic features.

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Oxygenation Status in Normal Tissues, Pathological Tissues and Malignant Tumors: A pO2 Database Based on Electron Paramagnetic Resonance (EPR) Oximetry Measurements

Cited by 12 publications

References 216 publications

The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

History of EPR Studies from the H. M. Swartz Laboratories: Part 3—EPR Oximetry

Hand‐held electron spin resonance scanner for subcutaneous oximetry using OxyChip

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