Oxytocin does not stand alone

Putnam, Philip T.; Chang, Steve

doi:10.1098/rstb.2021.0047

Cited by 10 publications

(8 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a matter of fact, evidence in animal PD models is provided that OT administration may possess neuroprotective effects on dopaminergic neurons related to anti-inflammatory, antioxidant, and anti-apoptotic activities [103], that dopamine levels increased when OT was administrated [104], that the OT levels were decreased in the models, that OT supplementation rescued locomotor disabilities and anxiety-like behaviors [101], and that after intranasal administration OT concentrates in brain regions including the striatum [105]; nevertheless, studies investigating OT in PD clinical settings are still needed [106]. In fact, critical examinations appear fundamental for enabling the utilization of OT mechanisms as a curative tool in psychiatric disorders, in particular when considering that the understanding of how OT impacts social behavior is still insufficient, life experience can change the OT systems function, and the OT effects appear highly context-dependent [107]. In addition, assessing the effects of intranasal OT in patients would need proper dose-response studies, including control subjects for peripheral effects [108].…”

Section: Potential Relevance Of Striatal Astrocytic D2-otr Heteromersmentioning

confidence: 99%

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Amato

Averna

Guidolin

et al. 2023

IJMS

View full text Add to dashboard Cite

The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly considered to play roles in social or emotional behavior, and suggested to serve as a potential therapeutic target. Although roles of astrocytes in the modulatory effects of OT and dopamine in the central nervous system are well recognized, the possibility of D2-OTR receptor-receptor interaction in astrocytes has been neglected. In purified astrocyte processes from adult rat striatum, we assessed OTR and dopamine D2 receptor expression by confocal analysis. The effects of activation of these receptors were evaluated in the processes through a neurochemical study of glutamate release evoked by 4-aminopyridine; D2-OTR heteromerization was assessed by co-immunoprecipitation and proximity ligation assay (PLA). The structure of the possible D2-OTR heterodimer was estimated by a bioinformatic approach. We found that both D2 and OTR were expressed on the same astrocyte processes and controlled the release of glutamate, showing a facilitatory receptor-receptor interaction in the D2-OTR heteromers. Biochemical and biophysical evidence confirmed D2-OTR heterodimers on striatal astrocytes. The residues in the transmembrane domains four and five of both receptors are predicted to be mainly involved in the heteromerization. In conclusion, roles for astrocytic D2-OTR in the control of glutamatergic synapse functioning through modulation of astrocytic glutamate release should be taken into consideration when considering interactions between oxytocinergic and dopaminergic systems in striatum.

show abstract

Section: Potential Relevance Of Striatal Astrocytic D2-otr Heteromersmentioning

confidence: 99%

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Amato

Averna

Guidolin

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Intranasal OXT strengthens functional connectivity between the medial prefrontal cortex and limbic regions 83,84,85 and OXT receptor mRNA is decreased in the medial prefrontal cortex in a number of psychiatric disorders where moral behavior can be affected 86 . Oxytocin has extensive functional interactions with other transmitter systems 28,29 , and one possibility in the current moral behavioral context is through its interactions with serotonin signaling in the brain. Increasing serotonin concentrations using serotonin selective re-uptake inhibitor (SSRI) drugs such as citalopram increases OXT release 87 , and has been shown to increase harm aversion in a several experimental contexts, including moral decision making and unfair behavior in economic games [10][11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

“…While both OXT and AVP have extensive functional interactions with diffuse transmitters such as serotonin and dopamine which can influence moral behavior 28,29,30 , relatively little is known about their respective influences on moral behavior. Studies investigating effects of intranasal OXT in the social cognition domain most relevant to moral behavior have reported facilitation of emotion processing 31,32 , parochial and/or universal altruism 33,34 , emotional empathy 35,36,37 and empathy for the pain of others 38 , paternal responses to children 39 , co-operative behavior [40][41][42][43] and generosity 44,45 as well as punishment for betrayal of trust 46 , although with some sex differences 43,46 .…”

Section: Introductionmentioning

confidence: 99%

Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame

Zheng,

Wang,

Yang

et al. 2023

Preprint

View full text Add to dashboard Cite

Prosocial and moral behaviors have overlapping neural systems but whether they involve similar neurochemical systems is unclear. In the current pre-registered randomized placebo controlled trial on 180 adult male and female subjects we investigated effects of intranasal administration of two prosocial neuropeptides, oxytocin or vasopressin, on moral emotion ratings for situations involving accidental or intentional harm to others and in judgments of moral dilemmas where harm is inflicted for a greater good. Oxytocin, but not vasopressin, enhanced feelings of guilt and shame only for intentional harm and reduced endorsement of choices where direct intentional harm to others could achieve a greater good. Effects of oxytocin on guilt and shame were partially mediated by trait empathy. Overall, findings demonstrate for the first time that oxytocin, but not vasopressin, promotes unwillingness to deliberately harm others irrespective of the consequences. This may reflect stronger associations between oxytocin and empathy and vasopressin with aggression.

show abstract

“…Thus, a more holistic and interactive approach regarding IN-OXT use in the clinical and nonclinical setting appears necessary ( Audunsdottir and Quintana, 2022 ; Putnam and Chang, 2022 ). This would require an acknowledgment of the relationship between the exogenous ways of administration and the endogenous oxytocin ( Mierop et al, 2020 ; Quintana and Guastella, 2020 ; Tabak et al, 2022 ).…”

Section: Perspectives On Future Directions In Clinical Researchmentioning

confidence: 99%

Dissecting social decision-making: A spotlight on oxytocinergic transmission

Coccia

Greca

Luca

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Social decision-making requires the ability to balance both the interests of the self and the interests of others to survive in social environments. Empathy is essential to the regulation of this type of interaction, and it often sustains relevant prosocial behaviors such as altruism and helping behavior. In the last decade, our capacity to assess affective and empathy-like behaviors in rodents has expanded our understanding of the neurobiological substrates that underly social decision-making processes such as prosocial behaviors. Within this context, oxytocinergic transmission is profoundly implicated in modulating some of the major components of social decision-making. Thus, this review will present evidence of the association between oxytocin and empathy-like and prosocial behaviors in nonhuman animals. Then, we will dissect the involvement of oxytocinergic transmission—across different brain regions and pathways—in some of the key elements of social decision-making such as emotional discrimination, social recognition, emotional contagion, social dominance, and social memory. Evidence of the modulatory role of oxytocin on social decision-making has raised considerable interest in its clinical relevance, therefore we will also discuss the controversial findings on intranasal oxytocin administration.

show abstract

Oxytocin does not stand alone

Cited by 10 publications

References 82 publications

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame

Dissecting social decision-making: A spotlight on oxytocinergic transmission

Contact Info

Product

Resources

About