Oxytocin promotes bone formation during the alveolar healing process in old acyclic female rats

Abstract

OT was found to promote bone formation and to inhibit bone resorption in old acyclic female rats during the alveolar healing process.

Longitudinal assessment of oxytocin efficacy on bone and bone marrow fat masses in a rabbit osteoporosis model through 3.0-T magnetic resonance spectroscopy and micro-CT

“…Human osteoblasts and osteoclasts express an oxytocin receptor [34]. Evidence shows that oxytocin promotes osteoblastogenesis, bone formation, and/or bone mass by peripherally affecting osteoblast oxytocin receptors [10,12,35,36]. Oxytocin promotes bone formation by decreasing circulating RANKL levels and increasing osteoprotegerin (OPG) levels, thereby decreasing the RANKL/OPG ratio [4,37,38], which indirectly promotes osteoclastogenesis.…”

“…Oxytocin inhibits adipocytes and stimulates osteoblast differentiation. Plasma oxytocin levels in ovariectomized (OVX) mice and rats were lower than those in sham-operated controls, and oxytocin plasma levels were significantly lower in postmenopausal women who developed osteoporosis than those in their healthy counterparts [10,12]. Osteoporosis remains significantly correlated with oxytocin in postmenopausal women of any age [9].…”

Bone healing with oxytocin‐loaded microporous β‐TCPbone substitute in ectopic bone formation model and critical‐sized osseous defect of rat

“…, , Colli et al. ). OT is a nonapeptide hormone composed of nine amino acids (Cys‐Tyr‐Ile‐Gln‐Asn‐Cys‐Pro‐Leu‐Gly‐NH 2 ) with a sulphur bridge between the two cysteines (Lee et al.…”

“…, , Colli et al. ). Regarding the potential effect of OT on bone formation, it has shown that OT favours bone formation through positive modulation of osteogenesis and osteoclastogenesis (Elabd et al.…”

“…, Colli et al. ), it is clearly suggested that OT might be an effective molecule for enhancing bone healing of osseous defects. However, all of the studies reporting the bone anabolic activity of OT have only evaluated the bone healing effect in rodents via systemic OT administration by peritoneal or subcutaneous injection (Elabd et al.…”