Oxytocin Secretion Is Associated with Severity of Disordered Eating Psychopathology and Insular Cortex Hypoactivation in Anorexia Nervosa

Lawson, Elizabeth A.; Holsen, Laura M.; Santin, McKale; Meenaghan, Erinne; Eddy, Kamryn T.; Becker, Anne E.; Herzog, David B.; Goldstein, Jill M.; Klibanski, Anne

doi:10.1210/jc.2012-1702

Cited by 109 publications

(103 citation statements)

References 44 publications

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“…Normal CSF OX concentrations, instead, have been reported in recovered AN patients (Chiodera et al, 1991). In two different recent papers, Lawson et al (2011Lawson et al ( , 2012 showed that overnight secretion of OX in AN patients was decreased compared with healthy controls and that after a standardized mixed meal mean plasma OX levels were higher in AN than in healthy controls. Higher OX secretion in response to a meal was associated with higher levels of disordered eating psychopathology.…”

Section: Oxytocinmentioning

confidence: 99%

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Tortorella

Brambilla

Fabrazzo

et al. 2014

Euro Eating Disorders Rev

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A large body of literature suggests the occurrence of a dysregulation in both central and peripheral modulators of appetite in patients with anorexia nervosa (AN) and bulimia nervosa (BN), but at the moment, the state or trait-dependent nature of those changes is far from being clear. It has been proposed, although not definitively proved, that peptide alterations, even when secondary to malnutrition and/or to aberrant eating behaviours, might contribute to the genesis and the maintenance of some symptomatic aspects of AN and BN, thus affecting the course and the prognosis of these disorders. This review focuses on the most significant literature studies that explored the physiology of those central and peripheral peptides, which have prominent effects on eating behaviour, body weight and energy homeostasis in patients with AN and BN. The relevance of peptide dysfunctions for the pathophysiology of eating disorders is critically discussed.

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Section: Oxytocinmentioning

confidence: 99%

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Tortorella

Brambilla

Fabrazzo

et al. 2014

Euro Eating Disorders Rev

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“…The effects induced by oxytocin may vary in individuals affected by different eating disorders. For example, a dysregulation of oxytocin secretion has been found in anorexic women but not in bulimic women [30,31]. Another study found that the administration of oxytocin nasal spray (40 IU) reduced food consumption in bulimic women but not in anorexic women [32].…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Nasal Spray in the Treatment of Binge Eating Disorder and Obesity: A Pilot, Randomized, Double-Blind Trial

Agabio¹,

Farci²,

Curreli³

et al. 2016

Clin Pharmacol Biopharm

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BackgroundPreclinical studies suggest that the neuropeptide oxytocin reduces food intake and body weight, but only a few clinical studies have investigated the translatability of these findings in humans. The present study investigated the safety and efficacy of oxytocin nasal spray in patients affected by binge eating disorder and obesity. MethodsSeventeen outpatients affected by binge eating disorder and obesity participated in a 8 week double-blind trial and received oxytocin (n=8; 24 IU, four times a day, 20 min before each of three meals and before going to bed) or placebo (n=9) with an energy-restricted diet. Primary outcomes included adverse events and the number of binge eating episodes per week. Secondary measures included body weight, BMI, severity of BED, craving for food, quality of sleep, quality of life, anxiety, and depressive symptoms. ResultsOne patient of oxytocin group discontinued prematurely the trial before the first post-randomization efficacy measure. Among the other 16 participants, 13 (81.2%) completed the trial, and 3 (18.8%) discontinued [3 in the oxytocin group; 0 in the placebo group (p=0.0625, Fisher's exact test)]. No significant difference between groups was found in any outcome evaluated. Patients of the placebo group performed slightly better than patients of the oxytocin group in some secondary outcomes, but these differences were not significant. ConclusionOxytocin nasal spray resulted to be safe, including in women of childbearing age but did not significantly reduce the number of binge eating episodes per week in outpatients affected by binge eating disorder and obesity. These findings are discussed in light of the human oxytocin literature.

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“…MAN-COVA (gender and WAIS-R as covariates) test was performed to investigate the effect of gender on blood levels of OT and WAIS-R on social cognition. OT data were divided into low (<400 pg/ml) and high (>400 pg/ml) categories, based on the distribution of the data and corroborated by previous reports on OT [35,36]…”

Section: Statistical Analysesmentioning

confidence: 97%

Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

Balıkçı

Aydın

Taş

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: There is substantial evidence from animal research indicating a key role of the neuropeptide oxytocin (OT) in the regulation of complex social cognition and behaviour. Social cognition is indispensable for social relationships for the whole of human society, and numerous studies have shown impaired social cognition in schizophrenia (SCH) and unaffected first-degree relatives also seem to be impaired, albeit to a lesser extent. Because of that, this study focuses on the role of OT in social cognition in SCH. Methods: Twenty-seven patients with SCH, 27 healthy siblings (HS) of these patients, and 27 psychologically healthy controls (HC) were included in the study. Blood samples were collected through a peripheral venous catheter. Differences in the socio-demographical and WAIS-R were tested by chi-square and one way-ANOVA. To explore the relationships between social cognition and blood samples we performed Pearson correlations. MANCOVA (gender and WAIS-R as covariates) test was performed to investigate the effect of gender on blood levels of OT and WAIS-R on social cognition. Results: Significant differences were found in neurocognitive and social cognitive capacity but not in OT levels. In the healthy control group, there was a positive correlation between blood OT levels and RMET. There is a statistically significant difference between high and low OT groups with regard to social cognition in all subtests of the RMET. Conclusions: In the current study, we found that patients had deficits in social cognition and neurocognition. Lower endogenous OT levels are also predictive for poor social cognitive functioning in HS and HC.ARTICLE HISTORY

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Oxytocin Secretion Is Associated with Severity of Disordered Eating Psychopathology and Insular Cortex Hypoactivation in Anorexia Nervosa

Abstract: Oxytocin may be involved in the pathophysiology of anorexia.

Cited by 109 publications

References 44 publications

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Oxytocin Nasal Spray in the Treatment of Binge Eating Disorder and Obesity: A Pilot, Randomized, Double-Blind Trial

Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

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