Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Scassellati, Catia; Galoforo, Antonio Carlo; Bonvicini, Cristian; Esposito, Ciro; Ricevuti, Giovanni

doi:10.1016/j.arr.2020.101138

Cited by 75 publications

(71 citation statements)

References 239 publications

(324 reference statements)

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“…Similar results have been obtained in laboratory experiments with animal models of rheumatoid arthritis and psoriasis [282][283][284][285][286][287], and with fibromyalgia [295][296][297][298][299][300][301]. Although data is limited, given the presence of mitochondrial dysfunction, oxidative injury, and inflammation in affected neuronal populations in the neurodegenerative disorders [302][303][304][305], it would seem that these conditions too would be suitable candidates for ozone PC.…”

Section: The Case For Ozonesupporting

confidence: 61%

Ozone Preconditioning: Waking up the dragon

Thorp¹,

Thorp²

2021

The GMS

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It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science.

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Section: The Case For Ozonesupporting

confidence: 61%

Ozone Preconditioning: Waking up the dragon

Thorp¹,

Thorp²

2021

The GMS

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“…Moreover, a high dose of O 3 promotes inflammation by the activation of the NF-κB pathway [ 64 ]. Additionally, the inhibition of the NF-κB pathway could potentially downregulate iNOS [ 68 ] because, for bortezomib treatment, it has been described that most of the infiltrating macrophages in the dorsal root ganglia are iNOS-expressing inflammatory macrophages [ 47 ].…”

Section: Modulation Of Oxidative Stress By Ozone Therapymentioning

confidence: 99%

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial

Clavo

Martı́nez-Sánchez²,

Rodrı́guez-Esparragón

et al. 2021

IJMS

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(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an adaptive antioxidant and anti-inflammatory response, which could be potentially useful in the management of CIPN. (2) Methods: The aims of this works are: (a) to summarize the potential mechanisms that could induce CIPN by the most relevant drugs (platinum, taxanes, vinca alkaloids, and bortezomib), with particular focus on the role of oxidative stress; (b) to summarize the current situation of prophylactic and treatment approaches; (c) to describe the action mechanisms of ozone therapy to modify oxidative stress and inflammation with its potential repercussions for CIPN; (d) to describe related experimental and clinical reports with ozone therapy in chemo-induced neurologic symptoms and CIPN; and (e) to show the main details about an ongoing focused clinical trial. (3) Results: A wide background relating to the mechanisms of action and a small number of experimental and clinical reports suggest that ozone therapy could be useful to prevent or improve CIPN. (4) Conclusions: Currently, there are no clinically relevant approaches for the prevention and treatment of stablished CIPN. The potential role of ozone therapy in this syndrome merits further research. Randomized controlled trials are ongoing.

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“…[27][28][29][30][31][32][33][34][35][36][37] These properties make ozone a useful medical tool, which can be used as either a disinfectant or an adjuvant agent in the therapy of numerous diseases. 32,[38][39][40] This paradox of ozone effect should be explained by the balance of NF-κB and Nrf2 signaling. Actually, many studies have been reported about the cross-talk between NF-κB and Nrf2, that Nrf2 plays a critical role in counteracting NF-κB driven inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Implication of NF-κB Activation on Ozone-Induced HO-1 Activation

Togi

Nagashima

et al. 2021

BPB Reports

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The controlled and moderate oxidative stress such as ozone induces both inflammatory and anti-inflammatory response. This balance is important for homeostasis of living organisms. Furthermore, it has been shown that this conflict response is mainly regulated by two transcriptional factors, nuclear transcriptional factor κB (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2). NF-κB is involved in inflammatory responses by regulating expression of cyclooxygenase-2 (COX-2) and various inflammatory cytokines while Nrf2 is involved in anti-inflammatory responses by controlling expression of numerous antioxidant enzymes such as heme oxygenase-1 (HO-1). We here demonstrate the molecular mechanisms of the crosstalk between NF-κB and Nrf2 activation during the moderate oxidative stress induced by ozone. We first confirmed the activation of NF-κB and Nrf2 signaling during the moderate oxidative stress in HeLa cells. Induction of NF-κB-mediated COX-2 mRNA expression was observed at the early phase after stimulation (30-60 min after ozone treatment). However, induction of HO-1 mRNA expression was observed at the late phase of stimulation (6 h after stimulation). To reveal the crosstalk between NF-κB and Nrf2, we tested whether reduction of NF-κB expression affects ozoneinduced Nrf2 activation by knocking down of NF-κB in HeLa cells. Importantly, the HO-1 induction by ozone was remarkably decreased by a reduction in NF-κB expression. These results suggest that the moderate oxidative stress by ozone initially induces NF-κB activation, and this NF-κB activation is required for HO-1 induction at the late phase of the moderate stress.

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Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Cited by 75 publications

References 239 publications

Ozone Preconditioning: Waking up the dragon

Ozone Preconditioning: Waking up the dragon

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial

Implication of NF-κB Activation on Ozone-Induced HO-1 Activation

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