Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects

Uraz, Ahu; Karaduman, Burcu; İşler, Sıla Çağrı; Gönen, Sevim; Çetiner, Deniz

doi:10.1016/j.jds.2018.06.005

Cited by 35 publications

(25 citation statements)

References 46 publications

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“…Our results are in accordance with a previous study conducted by Skurska et al [39], which demonstrated a significant decrease in periodontal inflammatory indices after the association of periodontal treatment and gaseous ozone compared to the control group. In contrast, Uraz et al [40] conducted a similar study showing that clinical parameters in patients with periodontitis did not improve with the adjunct of ozone therapy to conventional periodontal treatment. The authors observed that were no significant differences between two treatments groups for any of the microbiological, clinical and biochemical parameters.…”

Section: Discussionmentioning

confidence: 96%

The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial

Rapone

Ferrara

Corsalini

et al. 2020

IJERPH

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Background: It is established that inflammation is involved in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) by promoting insulin resistance and impaired beta cell function in the pancreas. Among the hypothesized independent risk factors implicated in the pathogenetic basis of disease, periodontal infection has been proposed to promote an amplification of the magnitude of the advanced glycation end product (AGE)-mediated upregulation of cytokine synthesis and secretion. These findings suggest an interrelationship between periodontal disease and type 2 diabetes, describing poor metabolic control in subjects with periodontitis as compared to nondiabetic subjects and more severe periodontitis in subjects with T2DM as compared to a healthy population, with a significant positive correlation between periodontal inflammatory parameters and glycated hemoglobin level. Results from clinical trials show that periodontal treatment is able to improve glycemic control in subjects with diabetes. Many therapeutic strategies have been developed to improve periodontal conditions in conjunction with conventional treatment, among which ozone (O3) is of specific concern. The principal aim of this trial was to compare the clinical effectiveness of an intensive periodontal intervention consisting of conventional periodontal treatment in conjunction with ozone gas therapy in reducing glycated hemoglobin level in type 2 diabetic patients and standard periodontal treatment. Methods: This study was a 12-month unmasked randomized trial and included 100 patients aged 40–74 years older, with type 2 diabetes mellitus diagnosed. All the patients received conventional periodontal treatment, or periodontal treatment in conjunction with ozone gas therapy in a randomly assigned order (1:1). The primary outcome was a clinical measure of glycated hemoglobin level at 3, 6, 9 and 12 months from randomization. Secondary outcomes were changes in periodontal inflammatory parameters. Results: At 12 months, the periodontal treatment in conjunction with ozone gas therapy did not show significant differences than standard therapy in decreasing glycated hemoglobin (HbA1C) level and the lack of significant differences in balance is evident. Conclusions: Although the change was not significant, periodontal treatment in conjunction with the gaseous ozone therapy tended to reduce the levels of glycated hemoglobin. The study shows a benefit with ozone therapy as compared to traditional periodontal treatment.

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Section: Discussionmentioning

confidence: 96%

The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial

Rapone

Ferrara

Corsalini

et al. 2020

IJERPH

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“…For Pg , a TaqMan-based assay was performed, according to Uraz et al [ 64 ], to quantify Pg 16S rRNA, the gene encoding the small subunit of 16S ribosomal RNA. The TaqMan Gene Expression Custom Assay was provided by Life Technologies (Thermo Fisher Scientific) with the following primers: 5′-GCGCTCAACGTTCAGCC-3′ forward primer, 5′-CACGAATTCCGCCTGC-3′ reverse primer and probe FAM-CACTGAACTCAAGCCCGGCAGTTTCAA-TAMRA.…”

Section: Methodsmentioning

confidence: 99%

The Potential of Colonic Tumor Tissue Fusobacterium nucleatum to Predict Staging and Its Interplay with Oral Abundance in Colon Cancer Patients

Pignatelli

Iezzi

Pennese

et al. 2021

Cancers

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Background. Intestinal microbiota dysbiosis may enhance the carcinogenicity of colon cancer (CC) by the proliferation and differentiation of epithelial cells. Oral Fusobacterium nucleatum (Fn) and Porphyromonas gingivalis (Pg) have the ability to invade the gut epithelium, promoting tumor progression. The aim of the study was to assess whether the abundance of these odontopathogenic bacteria was associated with colon cancer. We also investigated how lifestyle factors could influence the oral Fn and Pg abundance and CC. Methods. Thirty-six CC patients were included in the study to assess the Pg and Fn oral and colon tissue abundance by qPCR. Oral health data, food habits and lifestyles were also recorded. Results. Patients had a greater quantity of Fn in the oral cavity than matched CC and adjacent non-neoplastic mucosa (adj t) tissues (p = 0.004 and p < 0.001). Instead, Pg was not significantly detected in colonic tissues. There was an association between the Fn quantity in the oral and CC tissue and a statistically significant relation between the Fn abundance in adenocarcinoma (ADK) and staging (p = 0.016). The statistical analysis revealed a tendency towards a greater Fn quantity in CC (p = 0.073, η2p = 0.12) for high-meat consumers. Conclusion. In our study, Pg was absent in colon tissues but was correlated with the oral inflammation gingival and plaque indices. For the first time, there was evidence that the Fn oral concentration can influence colon tissue concentrations and predict CC prognosis.

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“…32 Nanomaterials like Bioactive glass, carbon nanomaterials, Titanium nanotubes covered dental inserts, nanoceramics for bone recovery; nanobiomaterial being utilized for the planning of platforms for recovery of periodontium; metallic nanoparticles as toothpaste and mouth flushes for control of oral biofilm and nanoparticles for neighborhood drug conveyance, Nanorobots for oral absense of pain, drug conveyance and so forth. 33 Examination is being done in the field of nanotechnology for delivering better and even adjusted items for periodontal recovery with the end of reactions and expanding the biocompatibility of the item. 34,35…”

Section: Nanotechnologymentioning

confidence: 99%

Latest advancement in periodontology

Hassan¹,

Bhateja²,

Arora³

et al. 2020

IJPI

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During that time a large portion of the exploration was centered around the microbiological parts of the periodontitis. It has been seen that microscopic organisms alone are not adequate for the inception of periodontal infections, despite the fact that they have a significant influence simultaneously. Host reaction, smoking, stress and other danger factors impact the presence of the infection, and the weakness to forceful types of periodontitis is hereditarily decided. This information carried critical changes to the idea of etiology, anticipation and the treatment of periodontal ailments. There is a tremendous measure of information on the bacterial part in the inception of periodontal pockets, changes in the junctional epithelium, annihilation of periodontal tendon and resorption of the alveolar bone. The microscopic organisms assume a roundabout function in the tissue pulverization, through actuation of the host reaction which gets obsessive. It appears hard to accept that a similar host reaction factors are capable both for the safeguard, just as the presence of the infection. Accordingly one of the fundamental inquiries that can be posed to today is the reason isn't simply the periodontal infection -restricting in its tendency, or for what reason doesn't it stop spontaniously. In this review we will tell the what are the recent advancements in periodontics.

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Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects

Cited by 35 publications

References 46 publications

The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial

The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial

The Potential of Colonic Tumor Tissue Fusobacterium nucleatum to Predict Staging and Its Interplay with Oral Abundance in Colon Cancer Patients

Latest advancement in periodontology

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