“Ozone” – The New Nemesis of Canker Sore

Dharmavaram, Ayesha Thabusum; Nallakunta, Rajesh

doi:10.7860/jcdr/2015/11911.5617

Cited by 3 publications

(6 citation statements)

References 13 publications

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“…In a similar study assessing the impact of ozonated olive oil on wound size in palatal wounds, wound size on days 5, 7, 14, 21 and 28 was consistently smaller in wounds treated with the ozonated olive oil versus pure olive oil ( P < 0.05) 32 . The remaining three studies examined the impact of ozonated water or oil on skin ulcers 29,31,33 . A 2015 study found that ulcers treated with ozonated oil had smaller wound sizes on days 2, 4, and 6 than wounds treated with pure sesame oil or distilled water ( P < 0.05) 29 .…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 13 studies had a mixture of low risk and unclear risk ratings. 19 , 21 , 24 , 25 , 26 , 27 , 29 , 30 , 33 , 35 , 36 , 37 , 40 …”

Section: Resultsmentioning

confidence: 99%

“…The remaining three studies examined the impact of ozonated water or oil on skin ulcers 29,31,33 . A 2015 study found that ulcers treated with ozonated oil had smaller wound sizes on days 2, 4, and 6 than wounds treated with pure sesame oil or distilled water ( P < 0.05) 29 . A 2017 study found ozonated oil plus a‐bisabolol spray applied to chronic venous leg ulcers produced smaller wound size at days 7, 14, and 30 compared to control 33 .…”

Section: Resultsmentioning

confidence: 99%

“…Three studies had high bias in blinding of participants and personnel, three had high risk in the blinding of outcome assessors, and four had other types of risk for high bias. The remaining 13 studies had a mixture of low risk and unclear risk ratings 19,21,24‐27,29,30,33,35‐37,40 …”

Section: Resultsmentioning

confidence: 99%

“…Five studies involving human patients that examined wound size post-intervention were included in this review. [29][30][31][32][33] (Table 2) All five studies reported reduced wound size in the ozonated treatment groups as compared to controls or standard care. Two studies examined the impact of ozonated oil or water on oral wounds.…”

Section: Human Studiesmentioning

confidence: 99%

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Liquid ozone therapies for the treatment of epithelial wounds: A systematic review and meta‐analysis

Romary

Landsberger

Bradner

et al. 2022

International Wound Journal

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Ozonated water and ozonated oils are emerging as potential therapies for wound care, but their efficacy has not been appropriately evaluated. The aim of this systematic review and meta‐analysis was to evaluate the therapeutic potential of topical ozone in the treatment of mammalian wounds. A structured search of five scientific databases returned a total of 390 unique studies. Of these, 22 studies were included in this review. Four studies provided enough data to be included in a meta‐analysis evaluating the time to complete wound healing. All studies were randomised controlled trials of humans or other mammalian animals that reported clinical signs of wound healing. Each study was critically analysed by a six‐point assessment of the risk of bias. Wounds treated with topical ozone had a greater reduction in wound size than similar wounds treated with controls or standard of care in all studies. Those treated with ozonated liquids also had a shorter time to wound healing by approximately one week. In conclusion, topical ozone contributed to enhanced wound healing in all studies. While additional human experiments would be helpful to quantify ozone's specific effects on wound healing compared to standard treatment, topical ozone should be considered as part of an overall wound management strategy.

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Section: Resultsmentioning

confidence: 99%

“…The remaining 13 studies had a mixture of low risk and unclear risk ratings. 19 , 21 , 24 , 25 , 26 , 27 , 29 , 30 , 33 , 35 , 36 , 37 , 40 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Human Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Liquid ozone therapies for the treatment of epithelial wounds: A systematic review and meta‐analysis

Romary

Landsberger

Bradner

et al. 2022

International Wound Journal

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Oral pathology in inflammatory bowel disease

Muhvić-Urek¹,

Tomac-Stojmenović²,

Mijandrušić-Sinčić³

2016

WJG

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The incidence of inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - has been increasing on a global scale, and progressively, more gastroenterologists will be included in the diagnosis and treatment of IBD. Although IBD primarily affects the intestinal tract, extraintestinal manifestations of the disease are often apparent, including in the oral cavity, especially in CD. Specific oral manifestations in patients with CD are as follows: indurate mucosal tags, cobblestoning and mucogingivitis, deep linear ulcerations and lip swelling with vertical fissures. The most common non-specific manifestations, such as aphthous stomatitis and angular cheilitis, occur in both diseases, while pyostomatitis vegetans is more pronounced in patients with UC. Non-specific lesions in the oral cavity can also be the result of malnutrition and drugs. Malnutrition, followed by anemia and mineral and vitamin deficiency, affects the oral cavity and teeth. Furthermore, all of the drug classes that are applied to the treatment of inflammatory bowel diseases can lead to alterations in the oral cavity due to the direct toxic effects of the drugs on oral tissues, as well as indirect immunosuppressive effects with a risk of developing opportunistic infections or bone marrow suppression. There is a higher occurrence of malignant diseases in patients with IBD, which is related to the disease itself and to the IBD-related therapy with a possible oral pathology. Treatment of oral lesions includes treatment of the alterations in the oral cavity according to the etiology together with treatment of the primary intestinal disease, which requires adequate knowledge and a strong cooperation between gastroenterologists and specialists in oral medicine.

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The usage of physiotherapeutic ozone therapy in periodontal and oral mucosal diseases – a review of the literature, supported by own observations

Masłyk,

Mazurek-Mocho,

Barczyk

et al. 2023

Fiz Pol

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Introduction. The usage of innovative therapeutic methods in the field of dentistry is con-stantly being researched with a goal to find an effective and safe strategies for the treatment of periodontal and oral mucosal diseases. In recent years, ozone therapy has become a subject of increased interest due to its potential benefits in the field of dental therapy. Ozone, the triatomic gas of oxygen, has gained prominence as an alternative form of therapy that can affect pathological changes within the oral cavity given its antibacterial and antifungal properties. Purpose of the study. The aim of this literature review is to evaluate the effectiveness of ozone therapy in dental treatment, with particular emphasis on the effect on periodontal and oral mucosal diseases, as well as tissue regeneration and reduction of pathogenic microorgan-isms within the oral cavity. Materials and methods. A systematic review of international literature published between 2000 and 2023 was conducted. This analysis included electronic databases such as PubMed, Google Scholar and EBSCO with the intention to collect and examine research findings. The selection of scientific papers was made taking into account the diversity of topics, methodological rigor and adherence to the principles of research ethics. In order to identify publications that met the established selection criteria, a multi-stage evaluating process was used, subjecting the chosen papers to critical evaluation. Conclusions. The usage of ozone therapy is a vast field of scientific research, subject to con-tinuous analysis, where the results are not always unanimous. In recent years, there has been noted a significant involvement of ozone (O3) in the field of periodontics and other dental disciplines. The effects of ozone and its therapeutic potential are a subject of detailed scientific research aimed at understanding the biological mechanisms and confirming the effectiveness of this form of therapy.

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“Ozone” – The New Nemesis of Canker Sore

Cited by 3 publications

References 13 publications

Liquid ozone therapies for the treatment of epithelial wounds: A systematic review and meta‐analysis

Liquid ozone therapies for the treatment of epithelial wounds: A systematic review and meta‐analysis

Oral pathology in inflammatory bowel disease

The usage of physiotherapeutic ozone therapy in periodontal and oral mucosal diseases – a review of the literature, supported by own observations

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