Ozone therapy: protocol for treating canine parvovirus infection

Abstract

Canine Parvovirus infection is a disease caused by Canine Parvovirus (CPV) that results in hemorrhagic gastroenteritis and secondary infections, mainly in puppies between six weeks and six months old that are not immunized. Since there is no specific treatment for the condition, supportive therapy based on antibiotics, antiemetics, and non-steroidal anti-inflammatory drugs is traditionally used. Ozone therapy is an economical treatment that has bactericidal, fungicidal, and antiviral properties, besides promoting oxygenation and tissue regeneration, as well as anti-inflammatory and analgesic effects, and was used as a complementary therapy in this study. Therefore, four mixed-breed dogs, aged between 2 and 3 months, with no previous immunization against CPV and testing positive for the virus in a rapid test were selected. The animals were randomly distributed into two groups, being 1: the control group (n=2) that received only supportive treatment; and 2: the experimental group (n=2), that in addition to conventional therapy received intravenously 500 mL of ozonized Ringer's Lactate solution. Before treatment and after 24 and 48 hours, the following clinical signs were evaluated: episodes of emesis and diarrhea, weight, hydration, blood glucose level, abdominal pain, and blood count. One control group animal died within the first hours of hospitalization. Both animals in the experimental group presented faster resolution of diarrheal episodes and shorter hospitalization time when compared to the surviving animal that received only supportive treatment. Although further studies are needed, ozone therapy showed promising results for the treatment of canine parvovirus.

Effective results of experimental herbal remedies in treating life- threatening viral infections in animals

“…Death is the sole outcome of certain acute viral infections in animals such as African swine fever, avian in uenza, canine distemper, and canine parvovirus infections [3][4][5][6][7][8][9][10][11][12][13][14][15][16] . The recent COVID-19 pandemic has led to many deaths [17][18][19][20][21] .…”

Impact of the Application of Gaseous Ozone on Selected Pathogens Found in Animal Shelters and Other Facilities

“…The effects described are utilized, for example, in water disinfection [5], and in the food industry for the disinfection of facilities, surface preservation of food products, and surface treatment of vegetables and fruits [3]. Ozone can be also successfully used in veterinary medicine as an alternative therapy in the treatment of some infectious diseases, e.g., canine parvovirus as documented by Dos Santos et al [6].…”

Ефективність Застосування Стабілізованого Водного Озону Для Санації Біоаерозолю Та Поверхонь У Клініках Ветеринарної Медицини

“…Даний генератор -це результат застосування передових технологій для отримання з кисню води його активної форми -О 3 з наступним розчиненням у воді. СВО проявляє сильну бактерицидну дію [13]. Проте, на відміну від газоподібного озону, є стійким, без запаху, не подразнює шкіру та слизові оболонки і, що важливо, не проявляє токсичної дії для людини (паспорт безпечності СВО становить 0-0-0-А) [14].…”