Ozonized Hydrogels vs. 1% Chlorhexidine Gel for the Clinical and Domiciliary Management of Peri-Implant Mucositis: A Randomized Clinical Trial

Butera, Andrea; Pascadopoli, Maurizio; Gallo, Simone; Martı́nez, Carlos Pérez; Val, José Eduardo Maté Sánchez de; Parisi, Luca; Gariboldi, Alice; Scribante, Andrea

doi:10.3390/jcm12041464

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…Still, the specifics of such antifungal mechanisms remain unexplored [ 5 ]. Future studies should investigate the impact of postbiotics and parabiotics as regulators of oral cavity homeostasis as they have shown promising results considering oral health and better outcomes of periodontal therapy [ 55 , 56 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Myco- and Bacteriobiota and Yeast Infections in Mechanically Ventilated COVID-19 Patients

Gregorczyk-Maga,

Kania,

Sulik-Tyszka

et al. 2023

Microorganisms

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Critically ill COVID-19 patients requiring mechanical ventilation in the intensive care unit are at risk of developing invasive candidiasis. In this study we aimed to (1) characterize oral cultivable mycobiota of mechanically ventilated adult COVID-19 patients in an ICU setting by sampling four distinct oral niches in two fixed time points with regards to oral health status, (2) investigate Candida spp. infections in this population, and (3) compare oral mycobiota with selected bacteriobiota strains during the observation in the ICU. We recruited 56 adult COVID-19 patients who qualified for mechanical ventilation. Patients received either standard or extended oral care procedures with tooth brushing. Oral samples were taken first within 36 h and after 7 days of intubation. Yeast-like fungi were identified by MALDI/TOF mass spectrometry. Yeast infection cases were retrospectively analyzed. Candida spp. in oral sampling was identified in 80.4% and 75.7%, C. albicans in 57.1% and 61.1%, and non-albicans Candida species in 48.2% and 47.2% patients at baseline and follow-up, respectively. There were no differences in the overall CFU counts of Candida spp. species and individual Candida species in oral samples, both at baseline and follow-up. At baseline, a higher prevalence of Candida spp. was associated with a higher identification rate of Lactobacillus spp. (64.4% vs. 27.3%, p = 0.041). At follow-up, there was a borderline lower prevalence of Candida spp. in patients with Lactobacillus spp. identified (57.1% vs. 87.0%, p = 0.057). The incidence rate of candidiasis was 5.4% and the incidence density was 3.1/1000 pds. In conclusion, non-albicans Candida species in oral samples were identified in nearly half of patients. Oral health was moderately impaired. A high incidence of yeast infections, including invasive cases, in patients hospitalized in the ICU due to COVID-19 and requiring mechanical ventilation was noted. Severe COVID-19 and disease-specific interventions within the ICU possibly played a major role promoting Candida spp. infections.

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Section: Discussionmentioning

confidence: 99%

Oral Myco- and Bacteriobiota and Yeast Infections in Mechanically Ventilated COVID-19 Patients

Gregorczyk-Maga,

Kania,

Sulik-Tyszka

et al. 2023

Microorganisms

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“…Antimicrobial bioadhesives represent an interesting approach to preventing bacterial growth while facilitating tissue regeneration in the treatment of peri-implantitis. In another clinical study [ 81 ], the effectiveness of an ozonized gel was assessed in comparison with chlorhexidine following a domiciliary oral hygiene protocol over a 6-month period. Both chlorhexidine and ozone emerged as valuable adjuncts for the in-office and at-home treatment of peri-implant mucositis.…”

Section: Drug Delivery Systems For Peri-implantitis Managementmentioning

confidence: 99%

The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment

Seoane-Viaño,

Seoane-Gigirey,

Bendicho-Lavilla

et al. 2024

Pharmaceutics

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Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an inflammatory nature, it is associated with the accumulation of plaque in the peri-implant tissues, and its evolution can be progressive depending on various factors, comorbidities, and poor oral health. Prophylaxis and different treatment methods have been widely discussed in recent decades, and surgical and non-surgical techniques present both advantages and disadvantages. In this work, a literature review of different studies on the application of adjuvant treatments, such as local and systemic antibiotics and antiseptic treatments, was conducted. Positive outcomes have been found in the short (up to one year after treatment) and long term (up to ten years after treatment) with combined therapies. However, there is still a need to explore new therapies based on the use of advanced drug delivery systems for the effective treatment of peri-implantitis in the long term and without relapses. Hence, micro- and nanoparticles, implants, and injectable hydrogels, among others, should be considered in future peri-implantitis treatment with the aim of enhancing overall therapy outcomes.

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“…Unlike antibiotics, ozone produces a broad-spectrum bactericidal effect through a physicochemical mechanism that kills bacteria quickly in only a few minutes. Furthermore, it can be released in a controlled manner to minimize damage to healthy tissues [106,107]. Scribante et al explored the use of probiotics to regulate oral microbial balance by promoting the growth of bacteria that benefit oral health.…”

Section: Hydrogels For Periodontal Tissue Regenerationmentioning

confidence: 99%

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

Chen,

Deng,

Lai

et al. 2023

Molecules

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Oral health is crucial to daily life, yet many people worldwide suffer from oral diseases. With the development of oral tissue engineering, there is a growing demand for dental biomaterials. Addressing oral diseases often requires a two-fold approach: fighting bacterial infections and promoting tissue growth. Hydrogels are promising tissue engineering biomaterials that show great potential for oral tissue regeneration and drug delivery. In this review, we present a classification of hydrogels commonly used in dental research, including natural and synthetic hydrogels. Furthermore, recent applications of these hydrogels in endodontic restorations, periodontal tissues, mandibular and oral soft tissue restorations, and related clinical studies are also discussed, including various antimicrobial and tissue growth promotion strategies used in the dental applications of hydrogels. While hydrogels have been increasingly studied in oral tissue engineering, there are still some challenges that need to be addressed for satisfactory clinical outcomes. This paper summarizes the current issues in the abovementioned application areas and discusses possible future developments.

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Ozonized Hydrogels vs. 1% Chlorhexidine Gel for the Clinical and Domiciliary Management of Peri-Implant Mucositis: A Randomized Clinical Trial

Cited by 10 publications

References 30 publications

Oral Myco- and Bacteriobiota and Yeast Infections in Mechanically Ventilated COVID-19 Patients

Oral Myco- and Bacteriobiota and Yeast Infections in Mechanically Ventilated COVID-19 Patients

The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment

Hydrogels for Oral Tissue Engineering: Challenges and Opportunities

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