P-012 CCL2 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer

Abstract

Introduction: Aberrant expression of CCL2 has been reported in a variety of malignancies and is associated with adverse prognosis including gastric cancer (GC). CCL2 has been shown to play a critical role in recruiting monocytes/macrophages. Our previous study has shown high infiltration of tumor-associated macrophages influence poor prognosis in human GC patients and associate with the phenomenon of epithelial-mesenchymal transition (EMT). The Snail family of transcription factors are core inducers of EMT. Methods: In our study, the expression of CCL2 and Snail in clinical specimens from 178 GC patients was detected by immunohistochemistry. Results: High expression of CCL2 was closely related to the pTNM stage (P < 0.001), depth of invasion (P < 0.001), nodal involvement (P < 0.001), metastasis (P = 0.002), and tumor diameter (P = 0.001), but not to the patients' gender (P = 0.115), age (P = 0.584), the Borrmann types (P = 0.197) and differentiation (P = 0.109). High expression of Snail was closely related to the pTNM stage (P < 0.001), depth of invasion (P < 0.001), nodal involvement (P < 0.001), metastasis (P = 0.001), the Borrmann types (P = 0.016), differentiation (P = 0.037) and tumor diameter (P < 0.001), but not to the patients' gender (P = 0.053) and age (P = 0.074). The results showed there is a link between CCL2 and Snail expression at protein levels (r = 40.751, P < 0.001). The