P.031 Chronic Coffee Consumption Has a Less Potent Effect on Aortic Stiffness Than Caffeine

Ioakeimidis, N.; Vlachopoulos, C.; Alexopoulos, Nikolaos; Dima, Ioanna; Xaplanteris, Panagiotis; Gravos, Athanasios; Baou, Katerina; Stefanadis, Christodoulos

doi:10.1016/j.artres.2007.07.088

Cited by 1 publication

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“…17 The finding that RC did not elicit vascular changes is the same result as reported in our previous work. 23 Although it is unclear why DC134 but not RC should produce cardiovascular effects when both drinks contained comparable amounts of caffeine, similar findings have been reported by other researchers investigating pulse wave velocity 51 and blood platelet activity. 52 The reduction of systolic pressure by RC in Phase 1 is likely due to decreases of dp/dt rather than changes of the vasculature, as both the arterial compliance and peripheral resistance parameters were unchanged.…”

Section: Caffeine Elicits Changes In Vascular Activitysupporting

confidence: 76%

“…A vasopressor effect on the aorta in the acute period has been reported in a number of studies on caffeine, coffee and tea utilising pulse wave velocity measures. [48][49][50][51] Markedly, the caffeine occurring in regular coffee had less acute effects on the aorta than added-caffeine in decaffeinated coffee. 51 Typically increases in blood pressure from coffee ingestion begin 15 min after ingestion 28 so it is not unexpected that blood pressure changes could occur as quickly as Phase 2.…”

Section: Caffeine Elicits Changes In Vascular Activitymentioning

confidence: 99%

“…[48][49][50][51] Markedly, the caffeine occurring in regular coffee had less acute effects on the aorta than added-caffeine in decaffeinated coffee. 51 Typically increases in blood pressure from coffee ingestion begin 15 min after ingestion 28 so it is not unexpected that blood pressure changes could occur as quickly as Phase 2. It is estimated that 15 min after the ingestion of soluble caffeine 75% of the caffeine is already present in the plasma.…”

Section: Caffeine Elicits Changes In Vascular Activitymentioning

confidence: 99%

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Caffeine in hot drinks elicits cephalic phase responses involving cardiac activity

et al. 2012

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Caffeine stimulates both oropharyngeal and gut bitter taste receptors (hTAS2Rs) and so has the potential to elicit reflex autonomic responses. Coffee containing 130 mg caffeine has been reported to increase heart rate for 30 min post-ingestion. Whereas added-caffeine, in doses of 25 to 200 mg, ingested with decaffeinated coffee/tea decreases heart rate 10 to 30 min post-ingestion. This study aimed to clarify caffeine's chemosensory impact. Double-espresso coffees were compared to a placebo-control capsule in a double-blind between-measures design. Coffees tested were regular coffee (130 mg caffeine) and decaffeinated coffee with added-caffeine (0, 67 and 134 mg). Cardiovascular measures from three post-ingestion phases: 1) 0 to 5; 2) 10 to 15; and 3) 25 to 30 min; were compared to pre-ingestion measures. Participants comprised 11 women in the control group and 10 women in the test group. Decaffeinated coffee elicited no changes. Decaffeinated coffee with 67 mg caffeine: decreased dp/dt in Phase 1. Decaffeinated coffee with 134 mg caffeine: increased heart rate in Phases 1 and 2; decreased spontaneous baroreflex sensitivity in Phase 1; and increased diastolic pressure in Phases 2 and 3. Regular coffee: increased heart rate in Phases 1 and 2; decreased dp/dt in all phases; and decreased systolic pressure in Phase 1. Caffeine is the substance in regular coffee which elicits chemosensory autonomic reflex responses, which involves heart activity and the baroreflex. Compared to the caffeine in regular coffee, added-caffeine elicits somewhat different chemosensory responses including a more pronounced pressor effect and resetting of the baroreflex. Caffeine in commonly consumed amounts, as well as modulating body processes by blocking adenosine receptors, can elicit reflex autonomic responses during the ingestion of caffeinated drinks. It is plausible that caffeine stimulates hTAS2Rs, during the ingestion of coffee, eliciting cephalic phase responses. These cephalic phase responses likely result from vagal withdrawal and it is uncertain whether they enhance digestion or not.

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