P.425 Extrahypothalamic CRH and its receptors change tyrosine hydroxylase expression after neonatal dexamethasone treatment

Сухарева, Е. В.; Ланшаков, Д. А.; Kalinina, Tatyana; Булыгина, В. В.; Дыгало, Н. Н.

doi:10.1016/j.euroneuro.2019.09.438

Cited by 1 publication

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“…Thus, the dexamethasone introduction in the neonatal period of development leads to an increase in the Crh expression in the brainstem in the first hours after the injection and to a complete restoration of the initial expression level by 6 hours, while the tyrosine hydroxylase gene expression (Th, a key enzyme in the norepinephrine synthesis) in this the same brain structure increased by 6 hours after dexamethasone administration, and the effect persisted 24 hours after exposure. However, preliminary administration of the CRHR antagonists -antalarmine and antisauvagin-30 before glucocorticoid therapy suppresses the increase of Th expression in the brainstem of neonatal rat pups caused by a single dexamethasone injection (Sukhareva et al, 2019). Based on this, it can be assumed that the use of these drugs can prevent the negative effects of hormone therapy in newborns in adulthood.…”

Section: Extrahypothalamic Crh: Organizing and Integrating Stress Responsementioning

confidence: 99%

The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response

Сухарева

2021

Vestn. VOGiS

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Stress is an essential part of everyday life. The neuropeptide corticotropin-releasing hormone (CRH, also called CRF and corticoliberin) plays a key role in the integration of neuroendocrine, autonomic and behavioral responses to stress. The activation of the hypothalamic-pituitary-adrenal axis (HPA axis) by neurons of the paraventricular hypothalamic nucleus (PVN), the primary site of synthesis CRH, triggers stress reactions. In addition to the hypothalamus, CRH is widespread in extrahypothalamic brain structures, where it functions as a neuromodulator for coordination and interaction between the humoral and behavioral aspects of a stress response. The axons of neurons expressing CRH are directed to various structures of the brain, where the neuropeptide interacts with specific receptors (CRHR1, CRHR2) and can affect various mediator systems that work together to transmit signals to different brain regions to cause many reactions to stress. Moreover, the effect of stress on brain functions varies from behavioral adaptation to increased survival and increased risk of developing mental disorders. Disturbances of the CRH system regulation are directly related to such disorders: mental pathologies (depression, anxiety, addictions), deviations of neuroendocrinological functions, inflammation, as well as the onset and development of neurodegenerative diseases such as Alzheimer’s disease. In addition, the role of CRH as a regulator of the neurons structure in the areas of the developing and mature brain has been established. To date, studies have been conducted in which CRHR1 is a target for antidepressants, which are, in fact, antagonists of this receptor. In this regard, the study of the participation of the CRH system and its receptors in negative effects on hormone-dependent systems, as well as the possibility of preventing them, is a promising task of modern physiological genetics. In this review, attention will be paid to the role of CRH in the regulation of response to stress, as well as to the involvement of extrahypothalamic CRH in pathophysiology and the correction of mental disorders.

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Section: Extrahypothalamic Crh: Organizing and Integrating Stress Responsementioning

confidence: 99%

The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response

Сухарева

2021

Vestn. VOGiS

View full text Add to dashboard Cite

show abstract

P.425 Extrahypothalamic CRH and its receptors change tyrosine hydroxylase expression after neonatal dexamethasone treatment

Cited by 1 publication

References 2 publications

The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response

The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response

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