P-758 SER, a novel time factor predictive for long-term survival in patients with limited disease small cell lung cancer after combined chest radiotherapy and chemotherapy

Ruysscher, Dirk De; Pijls, M; Bentzen, S.; Minken, A.; Wanders, S; Hochstenbag, Monique; Vansteenkiste, Johan; Wouters, Bradly G.; Boersma, L.; Lambin, Philippe

doi:10.1016/s0169-5002(05)81251-6

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The Chemoradiation Package and Ser1

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2006

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“…The theoretical basis of the superiority of initial chemoradiation is discussed in detail elsewhere. 57 This concept has recently been statistically evaluated by De Ruysscher et al 58 from The Netherlands. The hypothesis was that the overall treatment time available for accelerated proliferation of tumor cells could be a major determinant of tumor outcome in LSCLC.…”

Section: The Chemoradiation Package and Sermentioning

confidence: 99%

A Review of First-Line Treatment for Small-cell Lung Cancer

Murray¹,

Turrisi²

2006

Journal of Thoracic Oncology

109

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Although small-cell lung cancer (SCLC) makes up a smaller proportion of all lung cancers than it did 25 years ago, it remains a common cause of cancer mortality that requires more clinical and basic research than is currently underway. Trials of newer chemotherapy variations have failed to produce a regimen that is clearly superior to the two-drug combination of etoposide and cisplatin, which remains the standard of care for both limited and extensive stage SCLC. Paradoxically, advances in this systemic disease have come from radiotherapy innovations for limited SCLC, including addition of thoracic irradiation to systemic chemotherapy, more intense thoracic irradiation, early integration of thoracic irradiation with systemic chemotherapy, and prophylactic cranial irradiation.

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Section: The Chemoradiation Package and Sermentioning

confidence: 99%