P. G. Unna

Gans, Oscar

doi:10.1007/bf01745452

Cited by 9 publications

(14 citation statements)

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“…Residual distribution analysis is a method of model validation that is quite sensitive and does not require additional experimental work. It is trivial to calculate the residual distribution, and most of the common software packages do so automatically (i.e., WinEqNMR, HYPERQUAD, HYPNMR, Open Data Fit, etc. ) Such calculation should therefore be done routinely for every titration performed, and such residual distribution plots provided in the supporting information would increase the reliability of the presented data.…”

Section: Resultsmentioning

confidence: 99%

Recognizing the Limited Applicability of Job Plots in Studying Host–Guest Interactions in Supramolecular Chemistry

et al. 2016

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Continuous variation method, known as Job plot, is the most commonly applied method for the determination of stoichiometry of complex chemical entities for over 100 years. Although, the method was proven successful in the analysis of very stable metal-ligand complexes, we demonstrate that its use in supramolecular chemistry often provides false results. We support this statement with multiple simulations as well as cases studies of several real host-guest systems. We propose an alternative, general method relying on the analysis of residual distribution in titration data fitting. The latter method is more convenient compared to the Job plot and unlike it gives correct results in all real cases studied.

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Section: Resultsmentioning

confidence: 99%

Recognizing the Limited Applicability of Job Plots in Studying Host–Guest Interactions in Supramolecular Chemistry

et al. 2016

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“…Magmatism associated with detachment faulting is typically calc-alkaline (Table 2; Gans et al, 1989) and contains evidence of crustal contamination and magma mixing.…”

Section: Tectonic Overviewmentioning

confidence: 99%

Rift basins and supradetachment basins: intracontinental extensional end‐members

1995

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A B S T R A C TTwo end-members characterize a continuum of continental extensional tectonism: rift settings and highly extended terrains. These different styles result in and are recorded by different extensional basins. Intracontinental rifts (e.g. East Africa, Lake Baikal) usually occur in thermally equilibrated crust of normal thickness. Rift settings commonly display alkali to tholeiitic magmatism, steeply dipping (45-60") bounding faults, slip rates <1 mm yr-I and low-magnitude extension (10-25%). Total extension typically requires > 25 Myr. T h e fault and sub-basin geometry which dominates depositional style is a half-graben bounded by a steeply dipping normal fault. Associated basins are deep (6-10 km), and sedimentation is predominantly axial-or hangingwall-derived. Asymmetric subsidence localizes depocentres along the active basin-bounding scarp.Cyclade Islands) represent a different tectonic end-member. They form in back-arc regions where the crust has undergone dramatic thickening before extension, and usually reactivate recently deformed crust. Volcanism is typically calc-alkalic, and 8O-9O0/o of total extension requires much less time ( 2 mm yr-') and bulk extension (often > 100%) are high.The differences in extension magnitude and rate, volcanism, heat flow, and structural style suggest basin evolution will differ with tectonic setting. Supradetachment basins, or basins formed in highly extended terrains, have predominantly long, transverse drainage networks derived from the breakaway footwall. Depocentres are distal (10-20 km) to the main bounding fault. Basin fill is relatively thin (typically 1-3 km), probably due to rapid uplift of the tectonically and erosionally denuded footwall. Sedimentation rates are high (-1 m kyr-') and interrupted by substantial unconformities. In arid and semi-arid regions, fluvial systems are poorly developed and alluvial fans dominated by mass-wasting (debris-flow, rock-avalanche breccias, glide blocks) represent a significant proportion (30-50?/0) of basin fill. The key parameters for comparing supradetachment to rift systems are extension rate and amount, which are functions of other factors like crustal thickness, thermal state of the lithosphere and tectonic environment. Changes in these parameters over time appear to result in changes to basin systematics.Highly extended continental terrains (e.g. Colorado River extensional corridor, the

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“…Later, indications of a similar plateau effect using NIH-FSH-(S 1, S2, S3 and SS) all of ovine origin were noted (2)(3)(4). This study was prompted by the initial observation of Steelman and Pohley [Endocrinology 53, 604 (1953)l that the dose-response curve was restricted to a narrow range of FSH standard and furthermore that at levels above 0.3 mg FSH (Armour standard 264-151-X of porcine origin) the curve begins to plateau.…”

mentioning

confidence: 82%

“…Other implications of a plateau in response to high doses of follicle stimulating hormone (FSH) have been cited (2)(3)(4). Other implications of a plateau in response to high doses of follicle stimulating hormone (FSH) have been cited (2)(3)(4).…”

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confidence: 99%

A Systematic Analysis of the hCG Augmentation Assay for Follicle Stimulating Hormone

Jacobs

Ward

1973

Experimental Biology and Medicine

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The basis for this study arises from the early observation of Steelman and Pohley (1) that the dose-response curve has a narrow range and begins to plateau above 0.3 mg of standard. Other implications of a plateau in response to high doses of follicle stimulating hormone (FSH) have been cited (2-4). In the data presented here the existence and extent of this plateau effect is systematically demonstrated under several experimental conditions. Additionally, optimal conditions for control of much of the imprecision and insensitivity encountered in the Steelman-Pohley human chorionic gonadotropin (hCG) augmentation bioassay are reported. These results are significant in view of numerous earlier attempts to improve upon the Steelman-Pohley procedure as applied to rats (2,3, 5-1 1) and mice (12-15). Expert technical assistance was given by Theresa H. Pan and Jacqueline A.Cronquist.text. Each injection volume was 0.5 ml. Either the hCG and NIH-FSH-S9 were subcutaneously injected in the head and back for separate site injections a t each time interval, or alternatively the hCG and NIH-FSH-S9 were combined in saline for a single subcutaneous injection at each time interval. Five to 7 ratsJgroup were used in all experiments. Control groups received injections af hCG alone. One day prior to the first injection the hCG and NIH-FSH-S9 solutions were prepared by dissolving the compounds in saline (0.9% NaCl) containing 0.1% bovine albumin (purchased from Armour Pharmaceutical Co.) unless designated otherwise. All solutions were stored at 4' until injections. Seventy-two hours following the first injection the rats were sacrificed by carbon dioxide inhalation and their ovaries were removed. On saline moistened filter paper, adherent fat and connective tissue were gently teased away from the ovarian tissue. Immediately following cleaning the ovaries were weighed to the nearest 0.2 mg on a Roller-Smith balance.Results. Efiect of bovine albumin on doseresponse curve. Dose-response curves are presented in Fig. 1 for single site injections of hCG combined with FSH standard in saline with and without addition of 0.1% BSA, as designated in the legend. The dose-response curves are linear in all 3 cases with the highest overall response in rats receiving hCG and FSH in 0.1% BSA. The lower response was by rats receiving the same levels of hCG and FSH prepared in saline without additional BSA but prepared such that all solutions came in contact only with siliconized glassware. The presence of BSA seems effective in 106

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P. G. Unna

Cited by 9 publications

References 0 publications

Recognizing the Limited Applicability of Job Plots in Studying Host–Guest Interactions in Supramolecular Chemistry

Recognizing the Limited Applicability of Job Plots in Studying Host–Guest Interactions in Supramolecular Chemistry

Rift basins and supradetachment basins: intracontinental extensional end‐members

A Systematic Analysis of the hCG Augmentation Assay for Follicle Stimulating Hormone

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