P‐Selectin (CD62P) Expression in Liver Tissue of Biliary Atresia

Sira, Mostafa Mohamed; Sira, Ahmad Mohamed; Ehsan, Nermine; Mosbeh, Asmaa

doi:10.1097/mpg.0000000000000875

Cited by 12 publications

(8 citation statements)

References 48 publications

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“…The present study’s strength is analyzing a large cohort of NC cases with a long period of follow-up. Moreover, the designed simple algorithmic approach for the etiological diagnosis based on long-term experience [ 8 , 9 , 17 , 18 , 20 - 28 ] is another crucial point.…”

Section: Discussionmentioning

confidence: 99%

Variant etiologies of neonatal cholestasis and their outcome: a Middle East single-center experience

El‐Guindi

Saber

Shoeir

et al. 2021

ceh

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Section: Discussionmentioning

confidence: 99%

Variant etiologies of neonatal cholestasis and their outcome: a Middle East single-center experience

El‐Guindi

Saber

Shoeir

et al. 2021

ceh

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“…The reason for this separation is not to point out the discriminative laboratory or clinical parameters between both groups. We have already covered this issue extensively in our previous studies [10,11,21,22], so it will not be discussed here. But as BA is the main etiologic cause of neonatal cholestasis [23] and as CMV has been proposed as a possible etiologic agent for BA [18], this separation seemed logical.…”

Section: Discussionmentioning

confidence: 99%

“…The initial event may be a viral infection, which targets the biliary epithelium [8]. This is followed by activation of immune cells and release of proinfl ammatory cytokines [9] and adhesion molecules [10,11] that perpetuates the injury and causes biliary destruction, leading to the atresia phenotype [12].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Serological Markers of TORCH Infections in Biliary Atresia and Other Neonatal Cholestatic Disorders

Sira¹,

Sira²,

Elhenawy³

et al. 2016

Open J Pediatr Child Health

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Background: Viral infections, congenitally or perinatally acquired, have been associated with neonatal cholestasis. Investigators have suggested a similar link to biliary atresia (BA). Aim:The aim of the current study is to investigate the prevalence of serological markers of congential infections in BA and other neonatal cholestatic disorders.Methods: This retrospective study included 94 patients with confi rmed diagnosis of BA. A nearly comparable number of patients with cholestasis due to causes other than BA (n = 91) were also recruited and termed non-BA group. The data was retrieved from patients' records. TORCH (toxoplasma, rubella, cytomegalovirus [CMV] and herpes simplex virus [HSV] type 1 and type 2) antibodies (immunoglobulin [Ig] M and IgG) were performed in all the patients using enzyme-linked immunosorbent assay. CMV DNA was detected by polymerase chain reaction (PCR).Results: Both groups were age and sex matched (P>0.05). TORCH IgM antibodies were detedcted in 15.7% of all the study population (8.5% in BA group and 23% in non-BA group), of which CMV was the commonest agent. CMV IgM and CMV DNA by PCR were signifi cantly higher in non-BA group (20.9% and 23% respectively) than in BA group (4.3% and 5.3% respectively). Toxoplasma IgM was positive in only one patient in BA group and rublella IgM was positive only in one patient in the non-BA group. HSV-1 IgM was found in a total of 4 patients; 3 in BA group and one in non-BA group while HSV-2 IgM was negative in all the patients. CMV infection was the sole incriminated agent in 13 patients (CMV hepatitis), while it was associated with other etiologies such as pregressive familial intrahepatic cholestasis (5 of 29 patients), and intrahepatic biliary paucity (3 of 14 patients). Liver transaminases, prothrombin time and the frequency of growth failure were signifi cantly higher in non-BA group.Conclusions: TORCH IgM antibodies were detedcted in 8.5% of BA and in 23% of non-BA group, of which CMV was the commonest agent. In addition to CMV hepatitis, CMV infection was associated with other causes of neonatal cholestasis. For that, all cases with neonatal cholestasis should be thoroughly evaluated for other causes, even in cases with demonstrable CMV infection.

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“…The role of immune-mediate mechanism in the pathogenesis of BA has been based by the assumption that the initial damage of biliary epithelium is followed by the activation of immune cells and the release of proinflammatory cytokines that perpetuate the injury up to biliary destruction, which is followed by collagen deposition to produce biliary fibrosis (Besso and Bezerra 2011;Srivastava 2011;Sira et al 2015).…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Surgical Treatment of Biliary Tract Malformations in Newborns

Pedersini¹

2016

Neonatology

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P‐Selectin (CD62P) Expression in Liver Tissue of Biliary Atresia

Cited by 12 publications

References 48 publications

Variant etiologies of neonatal cholestasis and their outcome: a Middle East single-center experience

Variant etiologies of neonatal cholestasis and their outcome: a Middle East single-center experience

Prevalence of Serological Markers of TORCH Infections in Biliary Atresia and Other Neonatal Cholestatic Disorders

Surgical Treatment of Biliary Tract Malformations in Newborns

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