P0457 : Graphene quantum dots attenuate concanavalin A-induced hepatitis

Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death

“…Nevertheless, a line of evidence in addition to cytofluorometric assays supports the involvement of intracellular antioxidant activity of GQD in their cytoprotective action. Namely, in accordance with previous results obtained by us and others in various cell types in vitro and in vivo [19][20][21][22][23], the TEM analysis and the increase in cellular fluorescence confirmed that GQD were internalized by SH-SY5Y cells. Moreover, the removal of GQD from extracellular space only partly diminished their prosurvival effect, indicating its dependence on the intracellular accumulation of GQD.…”

“…They have excellent biocompatibility, broad antioxidant activity superior to that of classic antioxidants, and unique ability to mimic the action of cellular antioxidant enzyme superoxide dismutase [17,18]. The ability of GQD to enter various cell types, including neurons, is well documented [19][20][21][22][23]. While photoactivated GQD generate ROS [21,[24][25][26], in the absence of photoexcitation they act as antioxidants and protect cells by scavenging • OH, O2 •− [24,25], and NO [27].…”