2021
DOI: 10.1097/01.pcc.0000741256.49635.27
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P0730 / #2120: Weathering the Cytokine Storm: Anakinra for Car-T Related Hemophagocytic Lymphohistiocytosis in a Child

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“…One patient (3.7%) had HLH and cytokine‐release syndrome secondary to chimeric antigen receptor T‐cell therapy. No paediatric patient had HLH attributed to an oncological trigger per se, although four patients had concurrent/historical cancer diagnoses (B‐precursor acute myeloid leukaemia, two with neuroblastoma and Hodgkin lymphoma) 43,50,51,59 . The patients with neuroblastoma and Hodgkin lymphoma had significant infection (Table 1).…”
Section: Resultsmentioning
confidence: 99%
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“…One patient (3.7%) had HLH and cytokine‐release syndrome secondary to chimeric antigen receptor T‐cell therapy. No paediatric patient had HLH attributed to an oncological trigger per se, although four patients had concurrent/historical cancer diagnoses (B‐precursor acute myeloid leukaemia, two with neuroblastoma and Hodgkin lymphoma) 43,50,51,59 . The patients with neuroblastoma and Hodgkin lymphoma had significant infection (Table 1).…”
Section: Resultsmentioning
confidence: 99%
“…44 Whilst some COVID-19 patients had rheumatological and oncological co-morbidities, which may have contributed to sHLH/MAS susceptability, the underlying trigger was felt to be COVID-19 in all cases. 53,59 Of the n = 4 'other' triggers, these were an adult post-liver transplant for non-alcoholic steatohepatitis cirrhosis, 21 a 9-year-old with cytokine-release syndrome driven by chimeric antigen receptor T-cell therapy, 50 an adult with retained products of conception 44 and an adult with post-transplant-related lymphoproliferative disorder. 44 The sHLH triggers differed between paediatric and adult patients, with half of paediatric patients (<18 years) having a rheumatological diagnosis (48%) (Figure 2B), 25% being associated with severe or disseminated infection, and 18.5% having no known trigger.…”
Section: We Identified 28 Case Reports or Case Series With A Breadth ...mentioning
confidence: 99%
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