P0741 / #1916: Multisystem Inflammatory Syndrome in Children (Mis-C) Associated With Covid-19 Infection Presenting With Steven Johson Syndrome

Katlan, Banu; Nakip, O. Saritas; Kesici, Selman; Bayrakçı, Benan

doi:10.1097/01.pcc.0000741300.46124.ac

Cited by 5 publications

(6 citation statements)

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“…Both patients received broadspectrum antibiotics, immunomodulators, and plasma exchange. Despite this, they deteriorated, required venovenous extracorporeal exchange, and unfortunately died [2].…”

Section: Discussionmentioning

confidence: 99%

“…Both patients received broad-spectrum antibiotics, immunomodulators, and plasma exchange. Despite this, they deteriorated, required venovenous extracorporeal exchange, and unfortunately died [ 2 ]. Karimi A et al described a 25-month-old boy with fever and maculopapular rash that started in the feet and then generalized, progressed to bullae, and became ulcerated [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The cutaneous manifestations of MIS-C are variable, with very few cases describing Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) as a presenting feature. Katlan B et al and Karimi A et al described three patients with MIS-C and SJS [ 2 , 3 ]. Despite intensive treatment, the two patients described by Katlan B et al died [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Katlan B et al and Karimi A et al described three patients with MIS-C and SJS [ 2 , 3 ]. Despite intensive treatment, the two patients described by Katlan B et al died [ 2 ]. SJS/TEN, a severe and life-threatening mucocutaneous reaction triggered by drugs or infections, manifests as a painful purpuric rash that may blister as the disease progresses and involve the mucous membranes of the eyes, mouth, and genitalia [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Complete Remission in a Child With Multisystem Inflammatory Syndrome and Stevens-Johnson Syndrome Treated With Infliximab

Lootah¹,

Alshammari²,

Alqanatish³

2023

Cureus

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COVID-19, caused by SARS-CoV-2, can present with various dermatological manifestations, including (albeit rarely) severe mucocutaneous manifestations such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis. In contrast, multisystem inflammatory syndrome in children (MIS-C) commonly presents with mucocutaneous manifestations. The presentation of SJS in a child with MIS-C deserves increased attention from clinicians because of its potential fatality. Here we describe a 10-year-old boy with a history of exposure to confirmed COVID-19 who presented with fever, bilateral subconjunctival hemorrhage, cracked and red lips, oral ulcers, and generalized hemorrhagic skin lesions with targetoid lesions. Laboratory tests revealed leukocytosis, neutrophilia, lymphopenia, elevated C-reactive protein, sedimentation rate, ferritin, and B-type natriuretic peptide. A skin biopsy revealed patchy vacuolar interface dermatitis with subepidermal edema and superficial and deep perivascular predominantly histiocytic infiltrates with scattered eosinophils, lymphocytes, and neutrophils suggestive of SJS. In addition to supportive treatment, he was treated with IV methylprednisolone, immunoglobulins, and infliximab, after which his symptoms improved and gradually resolved.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Complete Remission in a Child With Multisystem Inflammatory Syndrome and Stevens-Johnson Syndrome Treated With Infliximab

Lootah¹,

Alshammari²,

Alqanatish³

2023

Cureus

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“…Although a previous study provided a report of suspected SJS in an adult patient with confirmed SARS-CoV-2 infection [ 16 ], Katlan et al reported two pediatric cases of COVID-19-associated MIS-C presenting with SJS [ 17 ] with impaired liver and kidney functions. Despite all treatments, severe hypoxia continued, leading to one of the case's death.…”

Section: Discussionmentioning

confidence: 99%

Is It Stevens–Johnson Syndrome or MIS-C with Mucocutaneous Involvement?

Karimi

Pourbakhtiaran

Fallahi

et al. 2021

Case Reports in Pediatrics

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Background. Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) can be present in the form of multisystem inflammatory disease in children. Case Presentation. A 25-month-old boy presented with fever, malaise, diffuse maculopapular rashes, and mucosal involvement during the COVID-19 pandemic. He was first diagnosed with Stevens–Johnson syndrome (SJS). Further evaluation revealed lymphopenia, thrombocytopenia, and elevated levels of C-reactive protein (CRP), ferritin, and fibrinogen. This was followed by a positive polymerase chain reaction (PCR) test for COVID-19. In addition to receiving initial care for SJS, he was treated for MIS-C, which led to his recovery after four days. Conclusion. COVID-19 infection should be considered in children with fever and dermatological features during the pandemic because it may cause different features of the multisystem inflammatory syndrome in children (MIS-C), suggestive of delayed hyperimmune response.

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The impact of COVID-19 on children's lives in the United States: Amplified inequities and a just path to recovery

Oberg

Hodges

Gander

et al. 2022

Current Problems in Pediatric and Adolescent Health Care

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P0741 / #1916: Multisystem Inflammatory Syndrome in Children (Mis-C) Associated With Covid-19 Infection Presenting With Steven Johson Syndrome

Cited by 5 publications

References 0 publications

Complete Remission in a Child With Multisystem Inflammatory Syndrome and Stevens-Johnson Syndrome Treated With Infliximab

Complete Remission in a Child With Multisystem Inflammatory Syndrome and Stevens-Johnson Syndrome Treated With Infliximab

Is It Stevens–Johnson Syndrome or MIS-C with Mucocutaneous Involvement?

The impact of COVID-19 on children's lives in the United States: Amplified inequities and a just path to recovery

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