P1.30: Teduglutide: the new weapon in pediatric short bowel syndrome

Use of Teduglutide in Children With Intestinal Failure: A Systematic Review

“…Bias due to confounding is low for five studies out of 14 ( 17 , 20 , 21 , 24 , 25 ). At the same time, the remainders present a moderate risk of bias due to small sample size and short follow up ( 9 , 12 , 15 , 18 , 19 , 26 ), different periods of treatment with teduglutide ( 26 ) and absence of stratification of results based on age bowel length ( 16 , 23 ) and teduglutide dose ( 22 ).…”

“…Intestinal length varied from a minimum of 0 cm to a maximum of 175 cm ( 18 , 20 ). Three papers did not specify the intestinal length at the beginning of treatment; the intestinal length mainly was determined by surgery with a total of 43 cases, even though only five papers stated the method used to determine the length of the remaining intestine in patients.…”

“…In 38 patients the Ileocecal valve was preserved (28%), while in 98 patients it was absent (72%) ( 12 , 15 – 18 , 23 , 24 , 26 ). In addition, in 6 studies, patients had been submitted to prior lengthening surgery ( 9 , 15 , 17 – 20 ) as the STEP procedure (serial transverse enteroplasty) in 82.4% of cases ( 15 , 17 , 18 , 20 ).…”

“…In 7 studies ( 9 , 12 , 15 , 17 , 19 , 20 , 25 ), patients were evaluated for changes in weight or height with an increase in weight in 6 cases and height in 5. However, in one study ( 25 ), patients did not improve weight or height after treatment.…”

“…Eight studies out of 14 evaluated changes in stool’s quality and all of them showed an improvement in patients’ stool either in reducing the number of evacuations per day or in better quality of stool ( 9 , 12 , 15 – 17 , 19 , 20 , 25 ).…”