P16 and MGMT Gene Methylation in Chronic Mechanical Irritation of the Oral Mucosa

Association between chronic mechanical irritation and oral cancer needs more original research

“…Current criteria of causality hold that a cocarcinogen may be a facilitating cause and a promoting factor could be a potentiating cause of a known carcinogen. In addition, there is biomolecular evidence linking CMI with conditions that promote OSCC (Gilligan et al, 2020;Lazos et al, 2020;Yoithapprabhunath et al, 2021).…”