P16^INK4a as an adjunct marker in liquid‐based cervical cytology

Molecular markers in cervical screening – a promise for the future

“…In HPV infection with high-risk types, p16 is over expressed in high-grade lesion and also in cervical carcinoma (25). The p16 protein can be detected in both histology specimens as well as liquid-bases cytology (26). Over-expression of p16 is correlated with HPV type 16 and 18 and can be detected in both squamous cell carcinoma and adenocarcinoma (27,28).…”

Immunohistochemical Detection of High Risk Human Papilloma Virus -16 in Cervical Smears- A Hospital Based Study

“…This may be attributed to poor hygiene which has been found to be associated with a higher prevalence of HPV in women as in a study conducted by Franceschi et al [2] Prevalence of HPV - 16 Of the 173 patients screened, 82 tested positive for HPV and 91 tested negative. A prevalence of 47.4% was obtained in the total no.…”

“…In our study there were only 6 cases with abnormal cytological results on Pap Smear. In a study conducted Shaira Sahebali et al [16] . Limitations of the study 1) As the study was conducted in a hospital set up in the outpatient department, it was difficult to obtain adequate patient details for evaluation of additional risk factors.…”

Human Papillomavirus in Cervical Cancer Screening: Important Role as Biomarker

“…Improved understanding of the molecular pathways of cervical carcinogenesis led to the discovery of clinically useful biomarkers. This translational research approach identified markers that reflect deregulation of the cell cycle in cervical neoplasia, such as p16, Ki-67, MCM proteins, and cyclin E (6,84,85). However, many of these biomarkers are only indicative of the presence of aberrant S-phase induction and lack specificity for cervical malignancy (6).…”