P17.04: Perinatal risk scale: detection of perinatal risk degree based on the results of antenatal ultrasonographic monitoring

Abstract

Poster discussion hub abstracts umbilical artery in pregnant women with moderate PE was 3.9 ± 0.8, in women with severe PE, SDR was higher than 4.39 ± 0.2. SDR in the umbilical artery in pregnant women with cholestatic hepatosis was 2.8 ± 0.3. In the group with a physiologically occurring pregnancy, 2.6 ± 0.19.The SDR in the uterine arteries are also significantly higher in pregnant women with moderate and severe PE -2.9 ± 0.4 and 2.93 ± 0.6, respectively, compared with the group of cholestatic hepatosis and control group -1.82 ± 0, 1 and 2.0 ± 0.2, respectively. In pregnant women with moderate PE, the SDR in MCA was 2.9 ± 0.2, in pregnant women with severe PE it was 2.7 ± 0.09. In women with cholestatic hepatosis, the SDR in MCA is comparable with the norm group -2.9 ± 0.08 and 3.1 ± 0.3, respectively. SDR in the hepatic artery was 2.78 ± 0.38 in the group with moderate PE, 2.9 ± 0.3 in the group with severe PE, which is significantly higher than the SDR in the norm group 2.1 ± 0.14 (p <0.05). In women with cholestatic hepatosis, SDR was comparable with the norm group and are 1.8 ± 0.4. Conclusions: The tendency to increase vascular resistance in the hepatic artery is traced in pregnant women with pre-eclampsia. In the group with cholestatic hepatosis, the parameters of hepatic hemodynamics practically do not differ from the norm. Objectives: The intrahepatic lipid content (IHLC) is increased in the neonatal offspring of obese women with gestational diabetes. However, it is still unknown, at which time point and to what extend the human liver stores lipids. The aim of this study was to evaluate if hepatic steatosis is already present in utero and if the presence of hepatic steatosis is associated with maternal body composition. Methods: We prospectively investigated the livers of 127 fetuses (gestational week 19-38) with mDixon multiecho sequences to assess the IHLC in both liver lobes. A proton density fat fraction (PDFF) of 0-3% was considered as no steatosis, a PDFF between 3.1 and 5% as mild steatosis, between 5.1 and 6.9% as moderate steatosis and above 6,9% as severe steatosis. Maternal body composition was evaluated; a pregestational BMI up to 25kg/m2 was considered to be normal, 25.1-30 kg/m2 to be overweighted and ≥30 kg/m2 to be obese. Results: A mild steatosis was found in 27/127 (21.3%) fetuses; the mean maternal BMI of these fetuses was 27.5 +±3.1kg/m2. In two fetuses (GW 34+0 and 33+5) we found a moderate steatosis; the maternal body composition was obese in both cases (BMI 30.4 and 30.9 kg/m2). Maternal body composition is statistically significant (0.017) associated with the presence of steatosis (normal n=50, 12%; overweight n=49, 26,5%; obesity n=28, 39,3%). Conclusions: Hepatic steatosis is already present in utero and associated with maternal body composition. However, proceeding the clinical study to increase the study population is necessary to prove our preliminary results. Objectives: To study the commonest risk factors and associations for intra-uterine death. Methods: This is a retrosp...

Congenital and Hereditary Pathology in Women Contracted Covid-19 During Pregnancy

“…In these circumstances, reducing perinatal mortality, and preserving the lives and health of newborns is a necessary condition for the demographic development of Ukraine and a factor in national security (Medvedev, M.V. et al, 2016;Safonova I.N., 2016).…”