P180 Correlation between patient reported outcomes of health-related quality of life and clinical activity in systemic lupus erythematosus patients

Abstract

bone mineral density (table 2). Factors associated with low bone mineral density in a univariate logistic regression analysis were: the use of mycophenolate mofetil (p=0.021) and the presence of LN (p=0.007), while LN also associated with low bone density (p= 0.008) in a multivariate analysis. The skin involvement was the most common clinical manifestation in both JSLE patient groups. The treatment was more aggressive in patients with LN, including the use of cyclophosphamide, mycophenolate and rituximab, but there was no difference regarding the length of the steroid treatment (table 3). The majority of the patients (67%) had one flare of nephritis and the number of flares ranged from 2 (13%) to 12 (2.2%) for the rest of the patients in this cohort with disease duration ranging from 8-12 years. The class of nephritis was reported in 34 out of 45 patients, and focal lupus nephritis (class III) was the most common type (44%). There were no statistical significant differences in the baseline characteristics or treatments among the different classes of LN. Conclusion Low bone mineral density is common in patients with JSLE 3 , but this is the first study highlighting the association of low bone density with LN and the lack of association with the total duration of steroid treatment or other clinical manifestations.