P2.04-06 Increased Plasma Cell % and Decreased B-Cells in Tumor Immune Infiltrates Are Associated with Worse Prognosis in Lung Adenocarcinomas

Lee, H.E.; Luo, Lei; Kroneman, Trynda N.; Passow, Marie R.; Rosario, Kristina Del; Christensen, Michael R; Francis, Mary; O'Shaughnessy, John W; Blahnik, Anthony J.; Yang, Ping; Yi, Eunhee S.

doi:10.1016/j.jtho.2018.08.1230

Cited by 7 publications

(11 citation statements)

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“…MUM1 (also known as IRF4), a member of the IRF family, is expressed mainly in the nucleus of B cells, particularly during the final phase of differentiation into plasma cells [43]. Recent investigations have demonstrated that elevated numbers of plasma cells could be associated with worse prognosis [44]. In a study on prostatic cancer, it was postulated that immunosuppressive IgA+ plasma cells within tumors induced CD8+ cell exhaustion and suppressed anti-tumor cytotoxic T cell responses through PD-L1 and IL-10 [45].…”

Section: Discussionmentioning

confidence: 99%

Equine Penile Squamous Cell Carcinomas as a Model for Human Disease: A Preliminary Investigation on Tumor Immune Microenvironment

Porcellato

Mecocci

Mechelli

et al. 2020

Cells

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Penile squamous cell carcinomas (SCCs) are common tumors in older horses, with poor prognosis mostly due to local invasion and recurrence. These tumors are thought to be mainly caused by Equus caballus papillomavirus type 2 (EcPV-2). The aim of this study is to characterize the tumor immune environment (TIME) in equine penile tumors. Equine penile epithelial tumors (17 epSCCs; 2 carcinomas in situ, CIS; 1 papilloma, P) were retrospectively selected; immune infiltrate was assessed by histology and immunohistochemistry; RT-qPCR tested the expression of selected chemokines and EcPV-2 DNA and RNA. The results confirmed EcPV-2-L1 DNA in 18/20 (90%) samples. L1 expression was instead retrieved in 13/20 cases (65%). The samples showed an increased infiltration of CD3+lymphocytes, macrophages (MAC387; IBA1), plasma cells (MUM1), and FoxP3+lymphocytes in the intra/peritumoral stroma when compared to extratumoral tissues (p < 0.05). Only MAC387+neutrophils were increased in EcPV-2high viral load samples (p < 0.05). IL12/p35 was differentially expressed in EcPVhigh and EcPVlow groups (p = 0.007). A significant decrease of IFNG and IL2 expression was highlighted in TGFB1-positive samples (p < 0.05). IBA1 and CD20 were intratumorally increased in cases where IL-10 was expressed (p < 0.005). EpSCCs may represent a good spontaneous model for the human counterpart. Further prospective studies are needed in order to confirm these preliminary results.

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Section: Discussionmentioning

confidence: 99%

Equine Penile Squamous Cell Carcinomas as a Model for Human Disease: A Preliminary Investigation on Tumor Immune Microenvironment

Porcellato

Mecocci

Mechelli

et al. 2020

Cells

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“…Extracellular or secreted HSPD1 can modulate the activation and function of various kinds of immune cells [ 15 ]. TIICs serve as key modulators in TME, and their composition is related to the prognosis and therapeutic response of LUAD patients [ 6 , 7 , 8 , 9 , 10 , 11 ]. Therefore, HSPD1 is an interesting molecule for further investigations of its potential as a biomarker for predicting prognosis and immune response and as a therapeutic target for LUAD.…”

Section: Discussionmentioning

confidence: 99%

“…HSPD1 is well known for its modulatory activity on many types of immune cells [ 15 ]. Composition of TIICs is related with clinical outcomes and therapeutic response in LUAD patients [ 6 , 7 , 8 , 9 , 10 , 11 ]. Therefore, it was of interest to investigate an association between HSPD1 expression and TIICs in LUAD.…”

Section: Discussionmentioning

confidence: 99%

“…Tumor-infiltrating immune cells (TIICs) are one of the key components in the tumor microenvironment (TME) that influence tumor progression and aggressiveness [ 5 ]. Previous studies have shown that TIICs are related to clinical outcomes and prognosis of LUAD patients [ 6 , 7 , 8 ]. The composition of TIICs also affects patients’ response to immunotherapy [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach

Aluksanasuwan,

Somsuan,

Ngoenkam

et al. 2024

Cancer Biomarkers

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BACKGROUND: Lung adenocarcinoma (LUAD) is a major histological subtype of lung cancer with a high mortality rate worldwide. Heat shock protein family D member 1 (HSPD1, also known as HSP60) is reported to be increased in tumor tissues of lung cancer patients compared with healthy control tissues. OBJECTIVE: We aimed to investigate the roles of HSPD1 in prognosis, carcinogenesis, and immune infiltration in LUAD using an integrative bioinformatic analysis. METHODS: HSPD1 expression in LUAD was investigated in several transcriptome-based and protein databases. Survival analysis was performed using the KM plotter and OSluca databases, while prognostic significance was independently confirmed through univariate and multivariate analyses. Integrative gene interaction network and enrichment analyses of HSPD1-correlated genes were performed to investigate the roles of HSPD1 in LUAD carcinogenesis. TIMER and TISIDB were used to analyze correlation between HSPD1 expression and immune cell infiltration. RESULTS: The mRNA and protein expressions of HSPD1 were higher in LUAD compared with normal tissues. High HSPD1 expression was associated with male gender and LUAD with advanced stages. High HSPD1 expression was an independent prognostic factor associated with poor survival in LUAD patients. HSPD1-correlated genes with prognostic impact were mainly involved in aberrant ribosome biogenesis, while LUAD patients with high HSPD1 expression had low tumor infiltrations of activated and immature B cells and CD4+ T cells. CONCLUSIONS: HSPD1 may play a role in the regulation of ribosome biogenesis and B cell-mediated immunity in LUAD. It could serve as a predictive biomarker for prognosis and immunotherapy response in LUAD.

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“…Tumor-in ltrating plasma cells are shown to play a positive role in antitumor immunity, suggesting that the potential of enhanced these response in the design of cancer immunotherapy (50). Lee et al demonstrated that increased Tumor-in ltrating plasma cells are associated with worse survival in lung adenocarcinomas (51). CD8 + T cells can enhance ferroptosis-speci c lipid peroxidation and, in turn, affect the anti-tumor e cacy of immunotherapy (52).…”

Section: Discussionmentioning

confidence: 99%

A Novel Ferroptosis-Related Gene Signature Robustly Predicts Clinical Prognosis And Tumor Immunity in Patients With Kidney Renal Clear Cell Carcinoma

Song¹,

Kang²,

Zhang³

2021

Preprint

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Objective: This study aimed to construct a ferroptosis-related gene signature to predict clinical prognosis and tumor immunity in patients with kidney renal clear cell carcinoma (KIRC).Methods: The mRNA expression profiles and corresponding clinical data of KIRC patients were downloaded from The Cancer Genome Atlas (TCGA), which were randomly divided into training (398 patients) and validation set (132 patients). The iron death related (IDR) prediction model was constructed based on training set and 60 ferroptosis-related genes from previous literatures, followed by prognostic performance evaluation and verification using the validation set. Moreover, functional enrichment, immune cell infiltration, metagene clusters correlation, and TIDE scoring analyses were performed. Results: In total, 23 ferroptosis-related genes were significantly associated with overall survival (OS). The IDR prediction model (a 10-gene signature) was then constructed to stratify patients into two risk groups. The OS of KIRC patients with high-risk scores was significantly shorter than those with low-risk scores. Moreover, the risk score was confirmed as an independent prognostic predictor for OS. The positive and negative correlated genes with this model were significantly enriched in p53 signaling pathway, and cGMP-PKG signaling pathway. The patients in the high-risk group had higher ratios of plasma cells, T cells CD8, and T cells regulatory Tregs. Furthermore, IgG, HCK, LCK, and Interferson metagenes were significantly correlated with risk score. By TIDE score analysis, patients in the high-risk group could benefit from immunotherapy.Conclusions: The identified ferroptosis-related gene signature is significantly correlated with clinical prognosis and immune immunity in KIRC patients.

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P2.04-06 Increased Plasma Cell % and Decreased B-Cells in Tumor Immune Infiltrates Are Associated with Worse Prognosis in Lung Adenocarcinomas

Cited by 7 publications

References 0 publications

Equine Penile Squamous Cell Carcinomas as a Model for Human Disease: A Preliminary Investigation on Tumor Immune Microenvironment

Equine Penile Squamous Cell Carcinomas as a Model for Human Disease: A Preliminary Investigation on Tumor Immune Microenvironment

Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach

A Novel Ferroptosis-Related Gene Signature Robustly Predicts Clinical Prognosis And Tumor Immunity in Patients With Kidney Renal Clear Cell Carcinoma

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