P2.04-34 FCGR2B Expression as a Regulator of Immunity in Non-Small Cell Lung Cancer Patients

Abstract

mutations/megabase; P¼0.004) than those in the PD-L1 TPS <1% group. Tumors in the PD-L1 TPS 90% group were more likely to have KRAS (47.3% vs 31.3%; P¼0.002), MET exon 14 (9.6% vs 2.1%; P¼0.003), and TP53 mutations (71.0% vs 49.7%; P<0.001) than those in the PD-L1 TPS <1% group. Compared to the PD-L1 TPS 90% group, the PD-L1 TPS <1% group was more likely to have EGFR (23.6% vs 8.2%; P<0.001) and STK11 (23.4% vs 5.0%; P<0.001) mutations, as well as the absence of known oncogenic driver mutations (35.2% vs 24.8%; P¼0.04). Chromosomal gain alterations (amplification or copy number gain) of the 9p24.1 locus, where the PD-L1, PD-L2, and JAK2 genes are located, were more common in the PD-L1 TPS 90% group than in the PD-L1 TPS <1% group (11.4% vs 2.8%, respectively; P<0.001). Chromosomal loss alterations (copy loss or deletion) of the 9p24.1 locus were more common in the PD-L1 TPS <1% than in the PD-L1 TPS 90% group (27.5% vs 3.8%, respectively; P<0.001). A repeated biopsy case showed acquired loss PD-L1 expression (PD-L1 TPS changed from 90% to 0%) with concomitant acquired loss of the 9p24.1 locus. Conclusion: High PD-L1 expression in NSCLC is associated with tobacco use, high TMB, gain of the 9p24.1 locus and mutations in KRAS, MET exon 14, and TP53. PD-L1 negativity is associated with never smoking status, low TMB, loss of the 9p24.1 locus, mutations in EGFR and STK11, and the absence of oncogenic driver mutations.

Development of an Immune-Related Prognostic Index Associated With Glioblastoma

“…FCGR2B belongs to the rhodopsin-like G-protein-coupled receptor family. It is expressed in multiple diseases, including systemic lupus erythematosus, non-small cell lung cancer, and IgA nephropathy liver hepatocellular carcinoma (38)(39)(40)(41)(42).…”