2017
DOI: 10.1016/j.jalz.2017.06.717
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[P2–068]: SOLUBLE AMYLOID‐BETA AGGREGATES FROM HUMAN ALZHEIMER's DISEASE BRAINS

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Cited by 7 publications
(9 citation statements)
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“…From these results, if oligomeric A is present in the ISF, it could be the predominant species that interacts with apoE in the ISF prior to binding to other cell surface molecules, such as receptors, thus leaving monomeric A to be the predominant species to be detected in the fluid phase. A recently developed method for isolating and characterizing the different oligomeric A species may facilitate more rigorous studies on the relative contribution of monomeric and oligomeric A to the APOE-mediated effects on amyloid pathology progression (55). This is an important question to address, considering the substantial body of literature supporting the role of A oligomers in facilitating neurotoxicity (56).…”
Section: Apoe-a Interactionmentioning
confidence: 99%
“…From these results, if oligomeric A is present in the ISF, it could be the predominant species that interacts with apoE in the ISF prior to binding to other cell surface molecules, such as receptors, thus leaving monomeric A to be the predominant species to be detected in the fluid phase. A recently developed method for isolating and characterizing the different oligomeric A species may facilitate more rigorous studies on the relative contribution of monomeric and oligomeric A to the APOE-mediated effects on amyloid pathology progression (55). This is an important question to address, considering the substantial body of literature supporting the role of A oligomers in facilitating neurotoxicity (56).…”
Section: Apoe-a Interactionmentioning
confidence: 99%
“…Finally, the sections were washed with PBS (3 × 2 min), DI water (2 min), and mounted with non-fluorescent mounting media. For antibody staining, six-month-old 5xFAD mouse brain sections were incubated with the AF594-conjugated anti-Aβ antibody (AF594-HJ3.4 antibody) 35,36 solution (1 µg/ml) at room temperature for 1 h. The stained brain sections were imaged using a Zeiss LSM 7010 confocal fluorescent microscope and Invitrogen EVOS FL Auto 2 Imaging System (Thermo Fisher, USA). Job's plots for solution stoichiometry determination.…”
Section: Introductionmentioning
confidence: 99%
“…A hallmark of the disease is the aggregation of the amyloid β (Aβ) peptide into fibrillar deposits known as amyloid plaques . However, research in the AD field points towards the soluble Aβ species, rather than the fibrillar deposits, as playing a key pathogenic role in the disease . The generation of Aβ peptides occurs through proteolytic processing of the transmembrane Aβ precursor protein (AβPP) by the β‐site AβPP‐cleaving enzyme (BACE1) followed by the intramembranous enzyme complex γ‐secretase .…”
mentioning
confidence: 99%