P2-111: Study on individual radiosensitivity of somatic cells in lung cancer patients

Abstract

among groups were estimated by χ 2 test, bone metastasis-free survival was analyzed by Kaplan-Meier method. The prognostic impact of clinicopathologic parameters and biomarker expression was evaluated by Cox propotional hazards model. Results: BSP expression was associated with BM(P=0.027), OPN expression could not reach statistical significance(P=0.495). Survival analysis demonstrated that strong expression of BSP(P=0.036), N stage(P=0.000) and overall stage(P=0.001) were associated with time interval to BM. Multivariate analysis showed BSP expression(RR=1.7 79,P=0.012) and overall stage(RR=1.620,P=0.005) were independent prognostic factors for BM.Conclusions: BSP protein expression in the primary resected NSCLC is strongly associated with BM and could be used to identify high-risk patients, and further improve treatment of NSCLC. Correlation of OPN protein expression and bone metastasis need further investigation.