P249 Hepatocellular Integrity in Patients Requiring Parenteral Nutrition: Comparison of a Fish Oil Containing New Lipid Emulsion Versus a Lipid Emulsion Based on Olive and Soybean Oil

Safety and Efficacy of a Lipid Emulsion Containing a Mixture of Soybean Oil, Medium‐chain Triglycerides, Olive Oil, and Fish Oil: A Randomised, Double‐blind Clinical Trial in Premature Infants Requiring Parenteral Nutrition

“…In surgical intensive care unit patients, total PN with SMOFlipid resulted in lower increases in liver enzymes, as compared with controls receiving a standard lipid emulsion based on soybean oil (22). Hepatic integrity was well preserved with the administration of SMOFlipid in postoperative patients, indicating good liver tolerance, as compared with patients receiving an emulsion based on olive and soybean oils (23). In a large, randomised, double‐blind multicentre trial in postoperative patients, more patients in the control group receiving a standard soybean emulsion had values of liver enzymes above the normal range than in the SMOFlipid group (24).…”