P264 Les complications infectieuses révélant le diabète type 2

Radi, L.; Chadli, A.; Ghomari, H. El; Farouqi, A.

doi:10.1016/s1262-3636(09)72062-2

Cited by 2 publications

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“…A similar situation was also found by the Bagir et al (9.3%) 16 . Indeed, the poor glycemic control would be at the origin of the presence of glycosuria favoring urinary microbial overgrowth, of a failure of the autonomic nervous system altering the dynamics of the excretory tract, and of the imbalance of the immune system disturbing the immune response 26 . Furthermore, the blood glucose level at admission of our patients was similar to that reported by Bagir et al (220 ± 107 mg/dL) 16 .…”

Section: Discussionsupporting

confidence: 74%

“…16 Indeed, the poor glycemic control would be at the origin of the presence of glycosuria favoring urinary microbial overgrowth, of a failure of the autonomic nervous system altering the dynamics of the excretory tract, and of the imbalance of the immune system disturbing the immune response. 26 Furthermore, the blood glucose level at admission of our patients was similar to that reported by Bagir et al (220 ± 107 mg/dL). 16 This could be explained by the fact that the diabetes was already poorly controlled and also that infection, like any state of stress, raises blood glucose levels.…”

Section: Antibioticmentioning

confidence: 99%

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Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug‐resistant bacterial infection

Raherison,

Raharinavalona,

Razanamparany

et al. 2023

Clinical Case Reports

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Key Clinical MessageThe main type of urinary tract infection in hospitalized diabetics in Antananarivo is acute pyelonephritis; Escherichia coli is the most isolated uropathogen; imipenem, amikacin, fosfomycin and ceftriaxone are the major antibiotics for which Escherichia coli retain good sensitivity; Type 2 diabetes is predictive factor for infection by multidrug resistant bacteria.AbstractThis study aimed to describe the epidemiological‐clinical profiles of diabetics hospitalized for bacterial urinary tract infections in the Endocrinology Department of Befelatanana Hospital, to identify the main bacteria responsible, their antibiotic sensitivity profile and the factors associated with multidrug‐resistant bacterial infection. A cross‐sectional study was conducted between March 2017 and March 2020 involving all diabetics hospitalized for documented community‐acquired bacterial urinary tract infection during this period. The hospital prevalence of urinary tract infections was 4.64%. The mean age of the patients was 59.06 ± 14.26 years and the sex ratio was 0.15. The main sign was fever (55.76%). The main clinical form was uncomplicated acute pyelonephritis (38.46%). Fifty‐seven bacterial uropathogens were isolated. The most frequent was Escherichia coli (77.19%). Escherichia coli was sensitive to ertapenem and nitrofurantoin in 100% of cases, to Amikacin in 97.5% of cases, to Fosfomycin in 94.4% of cases and to Ceftriaxone in 80.65% of cases. Thirteen patients were infected with multidrug‐resistant bacteria, all of them are extended‐spectrum beta‐lactamase‐producing Enterobacteriaceae. Only the type of diabetes was associated with multidrug‐resistant bacteria infection. The epidemiological‐clinical and biological characteristics of urinary tract infections in our diabetics are similar to those reported in the literature. Compliance with the rules of proper antibiotic use is imperative to limit the emergence and spread of multidrug‐resistant bacteria.

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Section: Discussionsupporting

confidence: 74%

Section: Antibioticmentioning

confidence: 99%

Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug‐resistant bacterial infection

Raherison,

Raharinavalona,

Razanamparany

et al. 2023

Clinical Case Reports

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“…Ces complications dégénératives vues au moment du diagnostic surtout chez les diabétiques de type 2 rendaient compte du cours de l'évolution naturelle de la maladie. En effet, selon la littérature, le diabète de type 2 évolue en moyenne depuis 5 à 7 ans [22] [23,24] ; elles occupaient dans notre étude, respectivement, la deuxième et la troisième place en termes de fréquence. L'incidence de la tuberculose pulmonaire serait plus importante chez les diabétiques du fait d'une dépression de l'immunité cellulaire, d'une production de cytokines, avec un rôle néfaste de la glycosylation non enzymatique [25,26], et surtout dans un pays à forte endémicité comme Madagascar [27].…”

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“…En effet, les diabétiques de type 1 (n= 28) dépendent de l'insuline pour survivre. Les patients infectés nécessitent une insulinothérapie pour équilibrer leur diabète puisque d'une part, l'infection est un facteur majeur de déséquilibre du diabète et d'autre part le diabète mal équilibré, à son tour, favorise et aggrave l'état infectieux [23]. Pour le reste, l'insulinothérapie a été maintenue soit parce que l'équilibre glycémique n'a pas été atteint avec les autres moyens thérapeutiques, soit parce qu'il existait une contre indication aux antidiabétiques oraux [29].…”

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Les nouveaux diabétiques observés à l’Hôpital Joseph Raseta Befelatanana d’Antananarivo (2002-2003)

Raherison,

Ramilitiana,

Raharinavalona

et al. 2015

Rev méd Madag

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Introduction. Diabetes mellitus is a heavy burden on public health in low-income countries. In Madagascar, few studies are available regarding diabetes mellitus in its discovery time. The aim of our study was to report the epidemiological and clinical aspects during discovery time of diabetes in Endocrinology service for a period of 12 months. Methodology. This is a descriptive retrospective survey realized in the service of Endocrinology of the Befelatanana Hospital, Antananarivo, from December 1st , 2002 to November 30, 2003. The retained patients were those who had newly diagnosed diabetes. Results. One hundred thirty patients were selected for the study. The incidence of diabetes in the service was 17.8%. The average age of patients was 46.9 years. The sex ratio was 1.06. One hundred two patients (78.5%) were type 2 diabetics. The average time between the first clinical manifestations of diabetes and diagnosis was 25 days. Most of our patients were symptomatic at the time of the discovery of their diabetes. The main signs associated with diabetes were physical asthenia (70%), weight loss (65.3%), polyuria (63.8%) and polydipsia (61.5%). Inaugural keto-acidosis had occurred in thirteen patients (10%). Coronaropathy occupied the first place (24.6%) in regarding degenerative complications already found at diagnosis of diabetes. Diabetic foot infection was the most common infectious complication. Insulin therapy was prescribed in 76.9% of our patients after hospitalization. Conclusion. In our practice, diabetes is often diagnosed late and at stage of complications. Efforts in screening for this disease are neces- sary; the results of this study will be used by practitioners as a tool to reinforce this strategy.

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P264 Les complications infectieuses révélant le diabète type 2

Cited by 2 publications

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Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug‐resistant bacterial infection

Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug‐resistant bacterial infection

Les nouveaux diabétiques observés à l’Hôpital Joseph Raseta Befelatanana d’Antananarivo (2002-2003)

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